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Anti-inflammatory Effect of Water Extract from Tuna Heart on Lipopolysaccharide-induced Inflammatory Responses in RAW 264.7 Cells
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  • Journal title : KSBB Journal
  • Volume 30, Issue 6,  2015, pp.326-331
  • Publisher : Korean Society for Biotechnology and Bioengineering
  • DOI : 10.7841/ksbbj.2015.30.6.326
 Title & Authors
Anti-inflammatory Effect of Water Extract from Tuna Heart on Lipopolysaccharide-induced Inflammatory Responses in RAW 264.7 Cells
Kim, Min-Ji; Bae, Nan-Young; Kim, Koth-Bong-Woo-Ri; Park, Ji-Hye; Park, Sun-Hee; Cho, Young-Je; Ahn, Dong-Hyun;
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 Abstract
The anti-inflammatory effect of tuna heart water extract (THWE) was investigated using lipopolysaccharide-induced inflammatory response in this study. Anti-inflammatory effect was detected by the cell proliferation and the production levels of nitric oxide, pro-inflammatory cytokines such as interleukin-6 (IL-6), IL-, and tumor necrosis factor-alpha. As a result, there were no cytotoxic effects on proliferation of macrophages treated with THWE compared to the control. The production of pro-inflammatory cytokines was remarkably suppressed compared with that of the LPS only group. These results suggest that THWE exerts the anti-inflammatory property by inhibiting production of inflammatory factors and may be a potential material for anti-inflammatory therapy.
 Keywords
Anti-inflammation;Pro-inflammatory cytokine;Nitric oxide;Tuna heart;
 Language
Korean
 Cited by
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