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Dietary Effects of Polymannuronate Added to Hamburger Buns on Lipid Metabolism in Rats
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 Title & Authors
Dietary Effects of Polymannuronate Added to Hamburger Buns on Lipid Metabolism in Rats
Joh, Ihn-Seon; Kim, In-Hye; Kwon, Mi-Jin; Nam, Taek-Jeong;
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The dietary fiber alginic acid has no nutritional value; however, it decreases the utilization of nutrients by the body and can prevent obesity, hyperlipidemia, arteriosclerosis, constipation, and colon cancer. The low-molecular-weight alginic acid polymannuronate improves serum and liver lipid metabolism by decreasing cholesterol levels in high-cholesterol groups and may be used to control high blood pressure. Previously, we showed that polymannuronate, a physiologically active agent from seaweed, has a lipid-lowering effect and preventative role in colon cancer. In addition, the differentiation of polymannuronate-treated adipocytes was inhibited, triggering decreased leptin expression. This study examined ways to increase dietary satisfaction with and improve the nutritional quality of polymannuronate using hamburger buns supplemented with polymannuronate. Twenty male Sprague-Dawley rats were divided into two groups: the control group was fed hamburger buns containing 6% gluten, while the experimental group was fed hamburger buns containing 6% gluten and 10% polymannuronate. The serum triglyceride, phospholipid, and total and free cholesterol levels of the rats in the experimental group were decreased compared with those of the controls. The serum aspartate aminotransferase activity levels did not differ between the two groups. This study demonstrates that polymannuronate has beneficial effects on lipid metabolism and may be commercially useful.
Hamburger buns;Polymannuronate;Lipid metabolism;Nutritional quality;
 Cited by
Choi JH, Kim JI, Kim IS, Choi JS, Byun DS and Yoon TH. 1991. Dose effect of brown algae (Undaria pinnatifida) on inhibitory action of obesity I. Effect on body weight, feed and growth efficiencies and metabolic body size. Kor J Gerontol 1, 168-172.

Frederich RC, Hamann A, Anderson S, Lollmann B, Iowell BB and Filer JS. 1995. Leptin levels reflect body lipid content in mice : evidence for diet-induced resistance to leptin action. Nature Med 1, 1311-1314. crossref(new window)

Haug A, Larsen B and Smidsrod O. 1974. Uronic acid sequence in alginate from different sources. Carbohyd Res 32, 217-225. crossref(new window)

Huh KB, Lee JH, Paik IK, Ajn KJ, Jung YJ, Kim MJ, Lee HC, Lee YH and Lee YJ. 1993. Influence of total abnormal fat accumulation on serum lipids and lipoproteins in Korean middle-aged men. Korean J Nutr 26, 299-312.

Joo DS, Lee JK, Choi YS, Cho SY, Je YK and Choi JW. 2003. Effect of seatangle oligosaccharide drink on hepatic lipids in rats fed a hyperlipidemic diet. J Korean Soc Food Sci Nutr 32, 1364-1369. crossref(new window)

Kim IH and Nam TJ. 2004. The effects of polymannuronates on leptin in 3T3-L1 adipocytes. J Kor Fish Soc 37, 372-379. crossref(new window)

Kim IH and Nam TJ. 2005. Inhibitory effect of low-molecularized polymannuronate on proliferation and DNA synthesis of human colon cancer cells. J Life Sci 15, 857-862. crossref(new window)

Kim YW. 2013. Improvement of leptin resistance. YUJM 30, 4-9.

Klein S, Coppack SW, Mohamed-Ali V and Landt M. 1996. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45, 984-987. crossref(new window)

Ko JS, Yoon JM, Yang HR, Myung JK, Kim H, Kang GH, Cheon JE and Seo JK. 2009. Clinical and histological features of nonalcoholic fatty liver disease in children. Dig Dis Sci 54, 2225-2230. crossref(new window)

Lee DS. 1997. Improved functionality of alginate from the edible brown algae by low-molecularization. Pukyong National University, Busan, Korea.

Lee DS, Kim HR and Pyeun JH. 1988. Effect of low-molecularization on rheological properties of alginate. J Korean Fish Soc 31, 82-89.

Mehta K, Van Thiel DH, Shah N and Mobarhan S. 2002. Nonalcoholic fatty liver disease : pathogenesis and the role of antioxidants. Nutr Rev 60, 289-293. crossref(new window)

Mirttinen TA. Dietary fiber and lipids. 1987. Am J Clin Nutr 45, 1237-1242.

Nishide E, Kinoshita Y, Anzai H and Uchida N. 1988. Distribution of hot-water extractable material, water-soluble alginate and alkali-soluble alginate in different parts of undaria pinnatifida. Nippon Suisan Gakkaishi 54, 1619-1622. crossref(new window)

Park HY, Yoon HD and Oh EK. 2001. Effect of Meristotheca papulosa on lipid concentration of serum and liver in rats fed high fed diet. J Korean Soc Food Sci Nutr 30, 107-111.

Park MY, Ahn SA, Cho WK, Cho KS, Park SH, Hahm SH, Jung MH and Suh BK. 2009. Serum leptin, adiponectin and resistin levels in obese children and their correlations with insulin resistance. Korean J Pedia 52, 766-771. crossref(new window)

Park SH, Jang MJ, Hong JH, Rhee SJ, Choi KH and Park MR. 2007. Effects of mulberry leaf extract feeding on lipid status of rats fed high cholesterol diets. J Kor Soc Food Sci Nutr 36, 43-50. crossref(new window)

Suzuki T, Nakai K, Yoshie Y, Shirai T and Hirano T. 1993. Effects of sodium alginates rich in guluronic acid mannuronic acids on cholesterol levels and digestive organs of highcholesterol-fed rats. Nippon Suisan Gakkaishi 59, 545-551. crossref(new window)

Tsuji, K., Horid, Y and Tsuji, E. 1974. Effect of konjac flour diet on the endogenous cholesterol metabolism in rats. Eiyogaku Zashi 27, 405-411.

Vahouny GV, Khalafi R, Satchithanandam S, Watkins DW, Story JA, Cassidy MM and Kritchevsky D. 1987. Dietary fiber supplementation and fecal bile acid, Neutral steroids and divalent cations in rats. J Nutr 117, 2009-2015.

Zhu W, Li D, Wang J, Wu H, Xia X, Bi W, Guan H and Zhang L. 2015. Effects of polymannuronate on performance, antioxidant capacity, immune status, cecal microflora, and volatile fatty acids in broiler chickens. Poul Sci 94, 345-352. crossref(new window)