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Transdermal Drug Delivery Devices Based on Microneedles: A Review
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 Title & Authors
Transdermal Drug Delivery Devices Based on Microneedles: A Review
Kim, Byeong Hee; Seo, Young Ho;
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This paper addresses the state of arts of microneedles for the transdermal drug delivery applications. Microneedles can be classified based on materials and shapes. For the materials, microneedles could be made of ceramics, metals and polymers. The shape of the microneedles can be classified into solid and hollow microneedles. Methods of transdermal drug delivery based on microneedle patch are discussed, and various fabrication methods of microneedle patches are introduced.
Solid and hollow microneedle;Transdermal drug delivery;Microfabrication;
 Cited by
Center BPR. Drug delivery systems and applications technologies. Biotech Policy Research Center, 2009.

Ochoa M, Mousoulis C, Ziaie B. Polymeric microdevices for transdermal and subcutaneous drug delivery. Adv Drug Del Rev 2012.

McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles for gene and drug delivery. Annu Rev Biomed Eng 2000;2:289-313. crossref(new window)

Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol 2008;26:1261-8. crossref(new window)

Henry S, McAllister DV, Allen MG, Prausnitz MR. Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 1998;87:922-5. crossref(new window)

Mitragotri S, editor. Recent developments in needle-free drug delivery. Frontiers of Engineering: Reports on Leading- Edge Engineering from the 2008 Symposium; 2009.

Karande P, Jain A, Ergun K, Kispersky V, Mitragotri S. Design principles of chemical penetration enhancers for transdermal drug delivery. Proc Natl Acad Sci U S A 2005;102:4688-93. crossref(new window)

Prausnitz MR. Microneedles for transdermal drug delivery. Adv Drug Del Rev 2004;56:581-7. crossref(new window)

Hashmi S, Ling P, Hashmi G, Reed M, Gaugler R, Trimmer W. Genetic transformation of nematodes using arrays of micromechanical piercing structures. Biotechniques 1995;19:766-70.

Mikszta JA, Alarcon JB, Brittingham JM, Sutter DE, Pettis RJ, Harvey NG. Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery. Nat Med 2002;8:415-9. crossref(new window)

Park J-H, Allen MG, Prausnitz MR. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Release 2005;104:51-66. crossref(new window)

Lee JW, Park J-H, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials 2008;29:2113-24. crossref(new window)

Lee I-C, He J-S, Tsai M-T, Lin K-C. Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery. Journal of Materials Chemistry B 2015;3:276-85. crossref(new window)

Lee KJ, Park SH, Lee JY, Joo HC, Jang EH, Youn Y-N, et al. Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury. J Control Release 2014;192:174-81. crossref(new window)

Choi CK, Lee KJ, Youn YN, Jang EH, Kim W, Min B-K, et al. Spatially discrete thermal drawing of biodegradable microneedles for vascular drug delivery. Eur J Pharm Biopharm 2013;83:224-33. crossref(new window)

Martanto W, Davis SP, Holiday NR, Wang J, Gill HS, Prausnitz MR. Transdermal delivery of insulin using microneedles in vivo. Pharm Res 2004;21:947-52. crossref(new window)

Uddin MJ, Scoutaris N, Klepetsanis P, Chowdhry B, Prausnitz MR, Douroumis D. Inkjet printing of transdermal microneedles for the delivery of anticancer agents. Int J Pharm 2015.

Matriano JA, Cormier M, Johnson J, Young WA, Buttery M, Nyam K, et al. $Macroflux^{(R)}$ microprojection array patch technology: a new and efficient approach for intracutaneous immunization. Pharm Res 2002;19:63-70. crossref(new window)

Chun K, Hashiguchi G, Toshiyoshi H, Le Pioufle B, Ishikawa J, editors. DNA injection into plant cell conglomerates by micromachined hollow microcapillary arrays. Proc. IEEE Micro Electro Mech. Syst. Workshop, 12th, Orlando, Piscataway, NJ: IEEE; 1999.

Van Damme P, Oosterhuis-Kafeja F, Van der Wielen M, Almagor Y, Sharon O, Levin Y. Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults. Vaccine 2009;27:454-9. crossref(new window)

Perennes F, Marmiroli B, Matteucci M, Tormen M, Vaccari L, Di Fabrizio E. Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol. J Micromech Microeng 2006;16:473. crossref(new window)

Yung K, Xu Y, Kang C, Liu H, Tam K, Ko S, et al. Sharp tipped plastic hollow microneedle array by microinjection moulding. J Micromech Microeng 2012;22:015016. crossref(new window)

Wang P-C, Paik S-J, Chen S, Rajaraman S, Kim S-H, Allen MG. Fabrication and characterization of polymer hollow microneedle array using UV lithography into micromolds. Microelectromechanical Systems, Journal of 2013;22:1041-53. crossref(new window)

Burton SA, Ng C-Y, Simmers R, Moeckly C, Brandwein D, Gilbert T, et al. Rapid intradermal delivery of liquid formulations using a hollow microstructured array. Pharm Res 2011;28:31-40. crossref(new window)

Kim K, Park DS, Lu HM, Che W, Kim K, Lee J-B, et al. A tapered hollow metallic microneedle array using backside exposure of SU-8. J Micromech Microeng 2004;14:597. crossref(new window)

McAllister D, Cros F, Davis S, Matta L, Prausnitz M, Allen M, editors. Three-dimensional hollow microneedle and microtube arrays. Transducers; 1999.

McAllister D, Kaushik S, Patel P, Mayberry J, Allen M, Prausnitz M, editors. Solid and hollow microneedles for transdermal drug delivery. Proc. Int. Symp. Control. Release Bioact. Mater., 26th, Boston; 1999.

Davis SP, Landis BJ, Adams ZH, Allen MG, Prausnitz MR. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. J Biomech 2004;37:1155-63. crossref(new window)

McAllister DV, Wang PM, Davis SP, Park J-H, Canatella PJ, Allen MG, et al. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc Natl Acad Sci 2003;100:13755-60. crossref(new window)