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Resistance Determinants and Antimicrobial Susceptibilities of Mupirocin-Resistant Staphylococci Isolated from a Korean Hospital
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  • Journal title : The Korean Journal of Microbiology
  • Volume 48, Issue 2,  2012, pp.93-101
  • Publisher : The Microbiological Society of Korea
  • DOI : 10.7845/kjm.2012.48.2.093
 Title & Authors
Resistance Determinants and Antimicrobial Susceptibilities of Mupirocin-Resistant Staphylococci Isolated from a Korean Hospital
Min, Yu-Hong; Lee, Jong-Seo; Kwon, Ae-Ran; Shim, Mi-Ja; Choi, Eung-Chil;
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 Abstract
We analyzed mupirocin resistance rates among staphylococcal isolates collected from a Korean hospital in 2003 (100 isolates), 2005 (195 isolates), 2006 (151 isolates), and 2009 (112 isolates). In Staphylococcus aureus, rates of high-level mupirocin resistance (MIC, minimal inhibitory concentration ) decreased and did not appear since 2005. In contrast, low-level mupirocin resistance (MIC ) was not detected in 2003 and 2005 but its rates later increased to 6.9% in 2009. Total resistance rates of coagulase-negative staphylococci (CNS) were significantly higher than those of S. aureus. The rates of high-level resistance of CNS increased from 16.0% in 2003 to 31.5% in 2009. The rate of low-level resistance of CNS was 8.0% in 2003 and around 11% later. In all high-level resistant isolates, the ileS-2 gene was detected. All low-level resistant isolates contained the known V588F mutation in ileS gene. Previously unknown mutations such as V458G in S. aureus and D172A, Y490H and I750V in CNS were identified additionally. One S. aureus isolate with high-level resistance was resistant to oxacillin and several topical antibiotics commonly used for the treatment of skin infection. Ten S. aureus isolates with low-level resistance were also resistant to all of these antibiotics except fusidic acid. CNS isolates with high-level (61 isolates) and low-level resistance (27 isolates) exhibited significantly higher resistance rates to these antibiotics than mupirocin-susceptible CNS isolates (167 isolates). In conclusion, prevention of the emergence of mupirocin resistance is necessary for the effective treatment of skin infection by staphylococci.
 Keywords
Staphylococcus aureus;coagulase-negative staphylococci;mupirocin;resistance;
 Language
Korean
 Cited by
1.
부산지역 치과환경에서 분리된 coagulase-negative staphylococci의 특성,정혜인;정소영;박인달;배일권;

생명과학회지, 2016. vol.26. 2, pp.220-225 crossref(new window)
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Characteristics of Coagulase-negative Staphylococci Isolates from Dental Clinic Environments in Busan, Korea, Journal of Life Science, 2016, 26, 2, 220  crossref(new windwow)
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