Advanced SearchSearch Tips
Evaluation of MCS Knockout Animal for Epilepsy Model
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Evaluation of MCS Knockout Animal for Epilepsy Model
Hwang, Kyu-Seok; Kim, Oc-Hee; Kim, Cheol-Hee;
  PDF(new window)
Epilepsy is a neurological disease characterized by recurrent seizures. Though the exact causes for epilepsy are unknown, genetic mutations, especially altered gene functions, have been implicated as key causative components of epilepsy. We recently identified a causing gene for the Miles-Carpenter syndrome (MCS). MCS patients have intellectual disability and epilepsy. MCS knockout (KO) zebrafish also show a seizure-like phenotype with hyperactivity of pectoral fin and jaw movement, resulting from loss of GABAergic interneurons. To evaluate MCS KO zebrafish as an epilepsy model, we tested the effects of retigabine, an anticonvulsant drug, on the movement of MCS KO zebrafish.
 Cited by
M. Pandolfo, "Genetics of Epilepsy", Seminars in Neurology, Vol. 30, No. 5, pp. 506-518, 2011.

S. F. Berkovic, J. C. Mulley, I. E. Scheffer, and S. Petrou, "Human Epilepsies: Interaction of Genetic and Acquired Factors", Trends in Neurosciences, Vol. 29, No. 7, pp. 391-397. 2006. crossref(new window)

S. Nadkarni and O. Devinsky, "Psychotropic Effects of Antiepileptic Drugs", Epilepsy Currents, Vol. 5, pp. 176-181. 2005. crossref(new window)

J. Y. Lee, W. S. Choi, S. H. Eun, B. L. Eun, Y. S. Hong, and J. W. Lee, "Use of Herbal Medicine in Epileptic Children", Korean Journal of Pediatrics, Vol. 51, No. 4, pp. 451-419. 2008.

J. H. Miles and N. J. Carpenter, "Unique X-Linked Mental Retardation Syndrome with Fingertip Arches and Contractures Linked to Xq21. 31", American Journal of Medical Genetics, Vol. 38, No. 2-3, pp. 215-223. 1991. crossref(new window)

M. May, K. S. Hwang, J. Miles, C. Williams, T. Niranjan, S. G. Kahler, P. Chiurazzi, K. Steindl, P. J. Van Der Spek, S. Swagemakers, J. Mueller, S. Stefl, E. Alexov, J. I. Ryu, J. H. Choi, H. T. Kim, P. Tarpey, G. Neri, L, Holloway, C. Skinner, R. E. Stevensson, R. I. Dorsky, T. Wang, C. E. Schwartz, and C. H. Kim, "ZC4H2, an XLID Gene, is Required for the Generation of a Specific Subset of CNS Interneurons", Human Molecular Genetics, Vol. 24, No. 17, pp. 4848-4861. 2015. crossref(new window)

M. Westerfield, "The Zebrafish Book: a Guide for the Laboratory of Zebrafish (Danio rerio)", University of Oregon Press. 2000.

C. Thisse and B. Thisse, "High-Resolution in situ Hybridization to Whole-Mount Zebrafish Embryos", Nature Protocol, Vol. 3, No. 1, pp. 59-69. 2008. crossref(new window)

Y. Kimura, C. Satou, and S. Higashijima, "V2a and V2b Neurons are Generated by the Final Divisions of Pair-Producing Progenitors in the Zebrafish Spinal Cord", Development, Vol. 135, No. 18, pp. 3001-3005. 2008. crossref(new window)

M. I. Coates., "Limb Evolution: Fish fins or tetrapod limbs - a simple twist of fate?", Current Biology, Vol. 5, pp. 844-848. 1995. crossref(new window)

P. A. Forcelli, C. Sopera, A. Lekhkara, K. Galea, and A. Kondratyeva, "Anticonvulsant Effect of Retigabine during Postnatal Development in Rats", Epilepsy Research, Vol. 101, pp. 135-140. 2012. crossref(new window)

Ma, L. H., Gilland, E., Bass, A. H. & Baker, R. "Ancestry of motor innervation to pectoral fin and forelimb", Nature Communiction, Vo. 1, No. 49, pp. 1-8. 2010..

Ma, L. H., Grove, C.L., Robert Baker, "Development of oculomotor circuitry independent of hox3 genes", Nature Communication, Vol. 5, No. 4221, pp. 1-12. 2013.

J. N, "Pathway-driven discovery of epilepsy genes", Nature Neurosciences, Vol. 18, No. 3, pp. 344-350. 2015. crossref(new window)

M. Cunningham, J. H. Cho, A. Leung, G. Savvidis, S. Ahn, M. Moon, P. K. J. Lee, J. J. Han, N. Azimi, K. S. Kim, V. Y. Bolshakov, and S. Chung, "hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizure and Abnormal Behavior in Eplieptic Mice", Cell Stem Cell, Vol. 15, pp. 559-573. 2014. crossref(new window)

Young-Lim Lee, "Limitations of neurobiological approach convergent to neuropsychiatry: DCD and two visual systems theory", Journal of digital Convergence, Vol. 13, No. 6, pp. 225-234, 2015.

Jong-Uk Kim, Sang-Cheol Park, Dae-Yong Jeon, "An Empirical Investigation on Factors Influencing SNS Addiction", Journal of digital Convergence, Vol. 13, No. 12, pp. 179-185, 2015.

Sang-Min Jun, "The Complex Effects of the Purposes of Using Mobile Phones on Mobile Phone Dependency and Depressive Symptoms among Elementary School Students", Journal of digital Convergence, Vol. 13, No. 10, pp. 471-482, 2015.

Kyung-A Jung, Bong-Whan Kim, "The Differences of the Ego-Resilience and Disagreement in Parents' Rearing Attitude according to the Levels of the Smartphone Addiction of Adolescents", Journal of digital Convergence, Vol. 13, No. 2, pp. 299-308, 2015. crossref(new window)

Gui-Jung Kim, Jung-Soo Han, "A Review of Research Trends on Brain Computer Interface(BCI) Games using Brain Wave", Journal of digital Convergence, Vol. 13, No. 6, pp. 177-184, 2015.

Min-Kyeong Kim, "Relationship of Multicultural Adolescents' Stress, Depression, Family Resilience and Internet Game Addiction", Journal of the Korea Convergence Society, Vol. 6, No. 7, pp. 205-210, 2016.

Kyoung-Mi Yang, "The Effect of Self-Esteem and Depression on Smartphone Addiction among University Students", Journal of the Korea Convergence Society, Vol. 6, No. 7, pp. 113-123, 2016.