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Evaluation of MCS Knockout Animal for Epilepsy Model
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 Title & Authors
Evaluation of MCS Knockout Animal for Epilepsy Model
Hwang, Kyu-Seok; Kim, Oc-Hee; Kim, Cheol-Hee;
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 Abstract
Epilepsy is a neurological disease characterized by recurrent seizures. Though the exact causes for epilepsy are unknown, genetic mutations, especially altered gene functions, have been implicated as key causative components of epilepsy. We recently identified a causing gene for the Miles-Carpenter syndrome (MCS). MCS patients have intellectual disability and epilepsy. MCS knockout (KO) zebrafish also show a seizure-like phenotype with hyperactivity of pectoral fin and jaw movement, resulting from loss of GABAergic interneurons. To evaluate MCS KO zebrafish as an epilepsy model, we tested the effects of retigabine, an anticonvulsant drug, on the movement of MCS KO zebrafish.
 Keywords
Epilepsy;Convergence;Zebrafish;Knockout;Retigabine;
 Language
Korean
 Cited by
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