JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Study on the Anti-inflammatory Effect of Kaempferol and Kaempferol Rhamnosides Isolated from Hibiscus cannabinus L.
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Study on the Anti-inflammatory Effect of Kaempferol and Kaempferol Rhamnosides Isolated from Hibiscus cannabinus L.
Lee, Keun-Ha; Cho, Young-Long; Joo, Chul-Gue; Joo, Yeon-Jeong; Kwon, Sun-Sang; Park, Chung;
  PDF(new window)
 Abstract
In this study, to evaluate the anti-inflammatory effects of kaempferol and its rhamnosides isolated from Hibiscus cannabinus L. leaves, we investigated UVB-induced inhibitory effects on inflammatory reaction by measuring the cytokine as the prostaglandin (), interleukine-6 (IL-6) and interleukine-8 (IL-8). We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC (thymus and activation-regulated chemokine) and . Kaempferol and -rhamnoisorobin showed inhibition activity of TARC generated to compared to positive control. Kaempferol, -rhamnoisorobin and afzelin Inhibited the release of . Also, only kaempferol significantly inhibited interleukine-6 (IL-6), interleukine-8 (IL-8) among UVB-induced inflammatory cytokine.
 Keywords
Kaempferol;Kaempferol Rhamnosides;Anti-inflammatory Effect;Hibiscus cannabinus L.;Cytokine;
 Language
Korean
 Cited by
1.
양마에서 분리한 Kaempferol과 그 배당체의 항균 및 주름억제 효과,이근하;공혜진;조영롱;주철규;권순상;황재성;박청;

한국약용작물학회지, 2012. vol.20. 6, pp.454-460 crossref(new window)
2.
대식세포 내에서의 홍화자 추출물의 항염증 활성,김동희;황은영;손준호;

생명과학회지, 2013. vol.23. 1, pp.55-62 crossref(new window)
3.
LPS로 유도한 RAW 264.7 세포의 염증반응에서 뚝새풀 에탄올 추출물의 억제 효과,정호경;강병만;장지훈;안병관;여준환;정원석;조정희;국용인;현규환;조현우;

한국약용작물학회지, 2014. vol.22. 2, pp.98-104 crossref(new window)
4.
천년초의 Taxifolin이 마우스대식세포(RAW 264.7 cell)에 미치는 항염증활성,김재영;이용화;안현진;이재덕;이용섭;

Journal of Applied Biological Chemistry, 2015. vol.58. 3, pp.241-246 crossref(new window)
1.
Anti-Inflammatory Activity of Carthamus tinctorious Seed Extracts in Raw 264.7 cells, Journal of Life Science, 2013, 23, 1, 55  crossref(new windwow)
2.
Anti-Microbial and Anti-Wrinkle Effect of Kaempferol and Kaempferol Rhamnosides isolated from Hibiscus cannabinus L., Korean Journal of Medicinal Crop Science, 2012, 20, 6, 454  crossref(new windwow)
3.
Inhibitory Effect of Alopecurus aequalis Sobol Ethanol Extracts on LPS-induced Inflammatory Response in RAW 264.7 Cells, Korean Journal of Medicinal Crop Science, 2014, 22, 2, 98  crossref(new windwow)
4.
Anti-inflammatory Activities of Taxifolin from Opuntia humifusa in Lipopolysaccharide Stimulated RAW 264.7 Murine Macrophages, Journal of Applied Biological Chemistry, 2015, 58, 3, 241  crossref(new windwow)
 References
1.
Jin CW, Eom SH, Park HJ, Ghimeray AK, Yu CY and Cho DH. (2009). Antioxidant activity of Hibiscus cannabinus L. leaves in different growth time. Korean Journal of Medicinal Crop Science. 17:21-25.

2.
Boller S, Soldi C, Marques MC, Santos EP, Cabrini DA, Pizzolatti MG, Zampronio AR and Otuki MF. (2009). Antiinflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation. Journal of Ethnopharmacology. 130:262-266.

3.
Fang SH, Rao YK and Tzeng YM. (2005). Inhibitory effects of flavonol glycosides from Cinnamomum osmopholeumon inflammatory mediators in LPS/IFN-γ-activatedmurine macrophages. Bioorganic & Medicinal Chemistry. 13:2381-2388. crossref(new window)

4.
Regasini LO, Vellosa JC, Silva DH, Furlan M, de Oliveira OM, Khalil NM, Brunetti IL, Young MC, Barreiro EJ and Bolzani VS. (2008). Flavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitors. Phytochemistry. 69:1739-1744. crossref(new window)

5.
De Melo GO, Malvar Ddo C, Vanderlinde FA, Rocha FF, Pires PA, Costa EA, de Matos LG, Kaiser CR and Costa SS. (2009). Antinociceptive and anti-inflammatory kaempferol glycosides from Sedumdendroideum. Journal of Ethnopharmacology. 12:4228-4232.

6.
Jorge AP, Horst H, de Sousa E, Pizzolatti MG and Silva FR. (2004). Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rats oleusmuscle. Chmico-Biological Interactions. 14:989-996.

7.
Vishnu Prasad CN, Suma Mohan S, Banerji A and Gopalakrishnapillai A. (2009). Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications. 380:39-43. crossref(new window)

8.
Tzeng YM, Chen K, Rao YK and Lee MJ. (2009). Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes. European Journal of Pharmacologica Neerlandica. 60:727-734.

9.
Tapiero H, Tew KD, Ba GN and Mathe G. (2002). Polyphenols: do they play a role in the prevention of human pathologies? Biomedicine and Pharmacotherapy. 56:200-207. crossref(new window)

10.
Rothwell JA, Day AJ and Morgan MR. (2005). Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids, Journal of Agricultural and Food Chemistry. 53:4355-4360. crossref(new window)

11.
Ross D, Mendiratta S, Qu ZC, Cobb CE and May JM. (1998). Ascorbate 6-palmitate protects human erythrocytes from oxidative damage. Free Radical Biology & Medicine. 26:81-89.

12.
Zuo Z, Zhang L, Zhou L, Chang Q and Chow M. (2006). Intestinal absorption of hawthorn flavonoids - in vitro, in situ and in vivo correlations. Life Science. 79:2455-2462. crossref(new window)

13.
O'Leary KA, Day AJ, Needs PW, Sly WS, O'Brien NM and Williamson G. (2001). Flavonoid glucuronides are substrates for human liver ?-glucuronidase. FEBS Letters. 503:103-106. crossref(new window)

14.
Navarro-Nunez L, Castillo J, Lozano ML, Martinez C, Benavente-Garcia O, Vicente V and Rivera J. (2009). Thromboxane $A^{2}$ receptor antagonism by flavonoids: structureactivity relationships. Journal of Agricultural and Food Chemistry. 57:1589-1594. crossref(new window)

15.
Guha M and Mackman N. (2001). LPS induction of gene expression in human monocytes. Cell Signalling. 13:85-94. crossref(new window)

16.
Lesslauer W, Tabuchi H, Gentz R, Brockhaus M, Schlaeger EJ and Grau G. (1991). Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharideinduced lethality. European Journal of Immunology. 21:2883-2886. crossref(new window)

17.
Cheon MS, Yoon TS, Choi GY, Kim SJ, Lee AY, Moon BC, Choo BK and Kim HK. (2009). Comparative study of extracts from rhubarb on inflammatory activity in raw 264.7 cells. Korean Journal of Medicinal Crop Science. 17:109-114.

18.
Yoon TS, Cheon MS, Kim SJ, Lee AY, Moon BC, Chun JM, Choo BK and Kim HK. (2010). Evaluation of solvent extraction on the anti-inflammatory efficacy of Glycyrrhiza uralensis. Korean Journal of Medicinal Crop Science. 18:28-33.

19.
Jin HI, Lee BR, Lim KJ, Trishna D, Shin HM and Lim BO. (2011). Anti-inflammatory effects of Prunus mune mixture in colitis induced by dextran sodium sulfate. Korean Journal of Medicinal Crop Science. 19: 16-23. crossref(new window)

20.
Chen Q, Koga T, Uchi H, Hara H, Terao H, Moroi Y, Urabe K and Furue M. (2002). Propionibacterium acnes-induced IL-8 production may be mediated by NF-kB activation in human monocytes, Journal of Dermatological Science. 29:97-103. crossref(new window)

21.
Vowels BR, Yang S and Leyden JJ. (1995). Induction of proinflammatory cytokines by a soluble factor of Propionibacterium ances: Implications for chronic inflammatory acne. Infection and Immunity. 63:3158-3165.

22.
Mandal PK, Freiter EM, Baqsby AL, Robertson FM and McMurray JS. (2011). Selective cyclooxygenase-2 inhibitor. Bioorganic & Medical Chemistry Letters. 21:6071-6073. crossref(new window)

23.
Dovle T, Chen Z, Muscoli C, Obeid LM and Salvemini D. (2011). Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-kB and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway. The FASEB Journal. 25:2782-2791. crossref(new window)