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The Neuroprotective Effect of White Ginseng (Panax ginseng C. A. Meyer) on the Trimethyltin (TMT)-Induced Memory Deficit Rats
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 Title & Authors
The Neuroprotective Effect of White Ginseng (Panax ginseng C. A. Meyer) on the Trimethyltin (TMT)-Induced Memory Deficit Rats
Lee, Seung-Eun; Shim, In-Sop; Kim, Geum-Soog; Yim, Sung-Vin; Park, Hyun-Jung; Shim, Hyun-Soo; Ye, Min-Sook; Kim, Seung-Yu;
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 Abstract
The present study examined the effects of Korean white ginseng (WG, Panax ginseng C. A. Meyer) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered with saline or WG (WG 100 or 300 mg/kg, p.o.) daily for 21 days. The cognitive improving efficacy of WG on the amnesic rats, which was induced by TMT, was investigated by assessing the Morris water maze test and by performing immunohistochemistries on choline acetyltransferase (ChAT), acetylcholinesterase (AchE), cAMP responsive element binding protein (CREB) and brain derived neurotrophic factor (BDNF). The rats treated with TMT injection (control group) showed impaired learning and memory of the tasks, but the rats treated with TMT injection and WG administration produced significant improvement of the escape latency to find the platform in the Morris water maze at the 2nd and 4th days compared to that of the control group. In the retention test, the WG 100 and WG 300 groups showed significantly increased crossing number around the platform compared to that of the control group (p < 0.001). Consistently with the behavioral data, result of immunohistochemistry analysis showed that WG 100 mg/kg significantly alleviated the loss of BDNF-ir neurons in the hippocampus compared to that of the control group (p < 0.01). Also, treatment with WG has a trend to be increased the cholinergic neurons in the hippocampal CA1 and CA3 areas as compared to that of the control group. These results suggest that WG may be useful for improving the cognitive function via regulation of neurotrophic activity.
 Keywords
Trimethyltin (TMT);Choline Acetyltransferase (ChAT);Water Maze;Acetylcholinestease;Brain Derived Neurotrophic Factor (BDNF);cAMP Responsive Element Binding Protein (CREB);White Ginseng;
 Language
Korean
 Cited by
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홍화 지상부 추출물의 전뇌허혈에 대한 신경보호 효과,김영옥;이상원;양승옥;나세원;김수강;정주호;

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 References
1.
Balaban CD, O'callaghan JP and Billingsley ML. (1988). Trimethyltin-induced neuronal damage in the rat brain: comparative studies using silver degeneration strains, immunocytochemistry and immune-assay for neuronotypic and gliotypic proteins. Neuroscience. 26:337-61. crossref(new window)

2.
Balin B, Abrams JT and Schrogie J. (2011). Toward a unifying hypothesis in the devleopment of Alzheimer's disease. CNS Neuroscience &Therapeutics. 17:587-589. crossref(new window)

3.
Castren E, Thoenen H and Lindholm D. (1995). Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus. Neuroscience. 64:71-80. crossref(new window)

4.
Chang LW and Dyer RS. (1983). A time-course study of trimethyltin induced neuropathology in rats. Neurobehavioral Toxicology and Teratology. 5:43-9.

5.
Chang LW and Dyer RS. (1985a). Septotemporal gradients of trimethyltin-induced hippocampal lesions. Neurobehavioral Toxicology and Teratology. 7:43-9.

6.
Chang LW and Dyer RS. (1985b). Trimethyltin induced pathology in sensory neurons. Neurobehavioral Toxicology and Teratology. 5:673-96.

7.
Chang LW and Dyer RS. (1985c). Species and strain comparison of acute neurotoxic effects of trimethyltin in mice and rats. Neurobehavioral Toxicology and Teratology. 5:337-50.

8.
Chang LW and Dyer RS. (1985d). Neuropathology of trimethyltin intoxication. III. Changes in the brain stem neurons. Environmental Research. 30:399-411.

9.
Choi JE, Nam KY, Kim BY, Cho HS and Hwang KB. (2010). Changes of chemical compositions and ginsenoside contents of different root parts of ginsengs with processing method. Korean Journal of Medicinal Crop Science. 18:118-125.

10.
Choi JH and Oh DH. (2009). Effect of white and red ginseng extracts on the immunological activities in lymphocytes isolated from Sasang constitution blood cells. Journal of Ginseng Research. 33:33-39. crossref(new window)

11.
Davinelli S, Intrieri M, Russo C, Di Costanzo A, Zella D, Bosco P and Scapagnini G. (2011). The "Alzheimer's disease signature": potential perspectives for novel biomarkers. Immunity & Ageing. 8:7-12. crossref(new window)

12.
Dyer RS. (1982). Physiological methods for assessment of trimethyltin exposure. Neurobehavioral Toxicology and Teratology. 4:659-64.

13.
Fortemps E, Amand G, Bomboir A. Lauwerys R and Laterre EC. (1978). Trimethyltin poisoning: report of two cases. Environmental Health : A Global Access Science Source. 41:1-6.

14.
Gray SG. (2011). Epigenetic treatment of neurological disease. Epigenomics. 3:431-450. crossref(new window)

15.
Hamilton DA, Johnson TE, Redhead ES and Verney SP. (2009). Control of rodent and human spatial navigation by room and apparatus cues. Behavioral Processes. 81:154-169. crossref(new window)

16.
Hwang EY, Kong YH, Lee YC, Kim YC, Yoo KM, Jo YO and Choi SY. (2006). Comparison of phenolic compounds contents between white and red ginseng and their inhibitory effect on melanin and biosynthesis. Journal of Ginseng Research. 30:82-87. crossref(new window)

17.
Ishida N, Akaike M, Tsutsumi S, Kanai H, Masui A, Sadamatsu M, Kuroda Y, Watanabe Y, Mxewen BS and Kato N. (1997). Trimethyltin syndrome as a hippocampal degeneration model:temporal changes and neurochemical features of seizure susceptibility and learning impairment. Neuroscience. 81:1183-1191. crossref(new window)

18.
Joo SS, Won TJ, Lee YJ, Hwang KW, Lee SG, Yoo YM and Lee DI. (2006). Ginsenoside $Rg_{3}$ from red ginseng prevents damage of neuronal cells through the phosphorylation of the cell survival protein Akt. Food Science and Biotechnology. 15:244-247.

19.
Kang H and Schuman EM. (1996). A requirement for local protein synthesis in neurotrophin-induced hippocampal synaptic plasticity. Science. 274:1402-1406.

20.
Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry JM and Bertschy G. (2005). Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet activity. Biological Psychiatry. 57:1068-1072. crossref(new window)

21.
Kim GS, Hyun DY, Kim YO, Lee SE, Kwon H, Cha SW, Park CB and Kim YB. (2010). Investigation of ginsenosides in different parts of Panax ginseng cultures by hydroponics. Korean Journal of Horticultural Science & Technology. 28:216-226.

22.
Koczyk D. (1996). How does trimethyltin affect the brain: facts and hypotheses. Acta Neurobiologiae Experimentalis. 56:587-96.

23.
Lee HJ, Kim JS, Moon C, Kim JC, Jo SK, Jang JS and Kim SH. (2009). Effect of red ginseng on radiation-induced learning and memory impairment in mouse. Journal of Ginseng Research. 33:132-138. crossref(new window)

24.
Liu XL, Xi QY, Yang L, Li HY, Jiang QY, Shu G, Wang SB, Gao P, Zhu XT and Zhang YL. (2011). The effect of dietary Panax ginseng polysaccharide extract on the immune responses in white shrimp, Litopenaeus vannamei. Fish Shelfish Immunology. 30:495-500. crossref(new window)

25.
Park JD. (1996). Recent studies on the chemical constituents of Korean ginseng (Panax ginseng C.A. Meyer). Journal of Ginseng Research. 30:389-415.

26.
Paxinos G and Watson C. (1986). The rat brain in stereotaxic coordinates. (2nd ed). Academic Press. New York, USA. p1-59.

27.
Radka SF, Holst PA, Fritsche M and Altar CA. (1996). Presence of brain derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Research. 709:122-130. crossref(new window)

28.
Robins Wahlin TB and Byrne GJ. (2010). Personality changes in Alzheimer's disease: a systematic review. International Journal of Geriatric Psychiatry. 26:1019-29.

29.
Stewart S, Cacucci F and Lever C. (2011). Which memory task for my mouse? A systematic review of spatial memory performance in the tg2576 Alzheimer's mouse model. Journal of Alzheimer's Disease. 26:105-26.