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Effects of Legumes Consumption on the Association of Cholesterol and Bone Mineral Density in Ovariectomized Rats
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 Title & Authors
Effects of Legumes Consumption on the Association of Cholesterol and Bone Mineral Density in Ovariectomized Rats
Kim, Jung-Min; Jin, Na; Park, Yong-Soon;
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 Abstract
Soy isoflavones have been suggested to improve bone loss and lipid profile in postmenopausal women and ovariectomized rats. In present study, we investigated the hypothesis that consumption of soybean, mung bean, cowpea and azuki bean has a beneficial effect on lipid profile which associates with bone mass in ovariectomized rats. Forty two female Sprague-Dawley rats were either sham-operated (Sham) or surgically ovariectomized (OVX). Sham and OVX groups were fed a regular AIN-93M diet, but ovariectomized rats with soybean (OS), mung bean (OM), cowpea (OC) or adzuki bean (OA) were fed AIN-93M diet replacing 35% of corn starch with powdered OS, OM, OC or OA for 10 weeks. Total- and LDL-cholesterol concentrations were significantly lower in Sham and OC groups than other OVX groups. There was significant negative association between total cholesterol concentration and bone mineral density (BMD) of tibia in only OC group. In conclusion, total-cholesterol concentration was significantly and negatively correlated with BMD in rats consumed cowpea, suggesting that the reduced cholesterol concentration may have a beneficial effect on bone mass.
 Keywords
Ovariectomized Rat;Legumes;Bone Mineral Density;Lipid Profile;
 Language
English
 Cited by
1.
수수 수집종의 농업적 형질 및 생리활성 분석을 통한 우수계통 선발,전미란;유지혜;김창흠;최재후;강병주;성은수;유창연;

한국약용작물학회지, 2016. vol.24. 5, pp.386-392 crossref(new window)
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