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Effects of Legumes Consumption on the Association of Cholesterol and Bone Mineral Density in Ovariectomized Rats
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 Title & Authors
Effects of Legumes Consumption on the Association of Cholesterol and Bone Mineral Density in Ovariectomized Rats
Kim, Jung-Min; Jin, Na; Park, Yong-Soon;
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Soy isoflavones have been suggested to improve bone loss and lipid profile in postmenopausal women and ovariectomized rats. In present study, we investigated the hypothesis that consumption of soybean, mung bean, cowpea and azuki bean has a beneficial effect on lipid profile which associates with bone mass in ovariectomized rats. Forty two female Sprague-Dawley rats were either sham-operated (Sham) or surgically ovariectomized (OVX). Sham and OVX groups were fed a regular AIN-93M diet, but ovariectomized rats with soybean (OS), mung bean (OM), cowpea (OC) or adzuki bean (OA) were fed AIN-93M diet replacing 35% of corn starch with powdered OS, OM, OC or OA for 10 weeks. Total- and LDL-cholesterol concentrations were significantly lower in Sham and OC groups than other OVX groups. There was significant negative association between total cholesterol concentration and bone mineral density (BMD) of tibia in only OC group. In conclusion, total-cholesterol concentration was significantly and negatively correlated with BMD in rats consumed cowpea, suggesting that the reduced cholesterol concentration may have a beneficial effect on bone mass.
Ovariectomized Rat;Legumes;Bone Mineral Density;Lipid Profile;
 Cited by
수수 수집종의 농업적 형질 및 생리활성 분석을 통한 우수계통 선발,전미란;유지혜;김창흠;최재후;강병주;성은수;유창연;

한국약용작물학회지, 2016. vol.24. 5, pp.386-392 crossref(new window)
Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J and Battaglia E. (2004). Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcified Tissue International. 74:136-142. crossref(new window)

Albertazzi P and Purdie D. (2008). Reprint of The nature and utility of the phytoestrogens: a review of the evidence. Maturitas. 61:214-226. crossref(new window)

Alexander JM, Bab I, Fish S, Müller R, Uchiyama T, Gronowicz G, Nahounou M, Zhao Q, White DW, Chorev M, Gazit D and Rosenblatt M. (2001). Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice. Journal of Bone and Mineral Research. 16:1665-1673. crossref(new window)

Borah B, Dufresne TE, Chmielewski PA, Gross GJ, Prenger MC and Phipps RJ. (2002). Risedronate preserves trabecular architecture and increases bone strength in vertebra of ovariectomized minipigs as measured by three-dimensional microcomputed tomography. Journal of Bone and Mineral Rresearch. 17:1139-1147. crossref(new window)

Brownbill RA and Ilich JZ. (2006). Lipid profile and bone paradox: higher serum lipids are associated with higher bone mineral density in postmenopausal women. Journal of Women's Health. 15:261-270. crossref(new window)

Chan KA, Andrade SE, Boles M, Buist DS, Chase GA, Donahue JG, Goodman MJ, Gurwitz JH, LaCroix AZ and Platt R. (2000). Inhibitors of hydroxymethylglutaryl -coenzyme A reductase and risk of fracture among older women. Lancet. 355:2185-2188. crossref(new window)

Cooper C, Westlake S, Harvey N, Javaid K, Dennison E and Hanson M. (2006). Review: developmental origins of osteoporotic fracture. Osteoporosis International. 17:337-347. crossref(new window)

Cos P, De Bruyne T, Apers S, Vanden Berghe D, Pieters L and Vlietinck AJ. (2003). Phytoestrogens: recent developments. Planta Medica. 69:589-599. crossref(new window)

Cui LH, Shin MH, Chung EK, Lee YH, Kweon SS, Park KS and Choi JS. (2005). Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporosis International. 16:1975-1981. crossref(new window)

Dang ZC, van Bezooijen RL, Karperien M, Papapoulos SE and Lowik CW. (2002). Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. Journal of Bone and Mineral Research. 17:394-405. crossref(new window)

Devareddy L, Khalil DA, Smith BJ, Lucas EA, Soung do Y, Marlow DD and Arjmandi BH. (2006). Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. Bone. 38:686-693. crossref(new window)

Edwards CJ, Hart DJ and Spector TD. (2000). Oral statins and increased bone-mineral density in postmenopausal women. Lancet. 355:2218-2219. crossref(new window)

Frota KM, Mendonca S, Saldiva PH, Cruz RJ and Areas JA. (2008). Cholesterol-lowering properties of whole cowpea seed and its protein isolate in hamsters. Journal of Food Science. 73:H235-H240. crossref(new window)

Gallo D, Zannoni GF, Apollonio P, Martinelli E, Ferlini C, Passetti G, Riva A, Morazzoni P, Bombardelli E and Scambia G. (2005). Characterization of the pharmacologic profile of a standardized soy extract in the ovariectomized rat model of menopause: effects on bone, uterus, and lipid profile. Menopause. 12:589-600. crossref(new window)

Chung IM, Kim KH and Ahn JK. (1998). Screening of korean medical and food plants with antioxidant activity. Korean Journal of Medicinal Crop Science. 6:311-322.

Khosla S, Atkinson EJ, Melton LJ 3rd and Riggs BL. (1997). Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study. The Journal of Clinical Endocrinology and Metabolism. 82:1522-1527. crossref(new window)

Lee SH, Jin N, Paik DJ, Kim DY, Chung IM and Park Y. (2011). Consumption of legumes improves certain bone markers in ovariectomized rats. Nutrition Research. 31:397-403. crossref(new window)

Lim BO, Park PJ, Park DK, Choi WS, Kim JD and Yu BP. (2007). The influence of long-term aloe supplement on antioxidative defenses and cholesterol content in brain and kidney of aged rats. Korean Journal of Medicinal Crop Science. 15:352-356.

Lin PY and Lai HM. (2006). Bioactive compounds in legumes and their germinated products. Journal of Agricultural and Food Chemistry 54:3807-3814. crossref(new window)

Lucas EA, Lightfoot SA, Hammond LJ, Devareddy L, Khalil DA, Daggy BP, Soung do Y and Arjmandi BH. (2003). Soy isoflavones prevent ovariectomy-induced atherosclerotic lesions in Golden Syrian hamster model of postmenopausal hyperlipidemia. Menopause. 10:314-321. crossref(new window)

Marathe SA, Rajalakshmi V, Jamdar SN and Sharma A. (2011). Comparative study on antioxidant activity of different varieties of commonly consumed legumes in India. Food and Chemical Toxicology. 49:2005-2012. crossref(new window)

McKane WR, Khosla S, Burritt MF, Kao PC, Wilson DM, Ory SJ and Riggs BL. (1995). Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause-a clinical research center study. The Journal of Clinical Endocrinology and Metabolism. 80:3458-3464. crossref(new window)

Olivera L, Canul RR, Pereira-Pacheco F, Cockburn J, Soldani F, McKenzie NH, Duncan M, Olvera-Novoa MA and Grant G. (2003). Nutritional and physiological responses of young growing rats to diets containing raw cowpea seed meal, protein isolate (globulins), or starch. Journal of Agricultural and Food Chemistry. 51:319-325. crossref(new window)

Orozco P. (2004). Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women. European Journal of Epidemiology. 19:1105-1112. crossref(new window)

Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA and Demer LL. (1997). Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arteriosclerosis, Thrombosis, and Vascular Biology. 17:680-687. crossref(new window)

Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M and Demer LL. (1999). Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. Journal of Bone and Mineral Research. 14:2067-2078. crossref(new window)

Parhami F, Garfinkel A and Demer LL. (2000). Role of lipids in osteoporosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 20:2346-2348. crossref(new window)

Parhami F, Mody N, Gharavi N, Ballard AJ, Tintut Y and Demer LL. (2002). Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. Journal of Bone and Mineral Research. 17:1997-2003. crossref(new window)

Reeves PG, Nielsen FH and Fahey GC Jr. (1993). AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. Journal of Nutrition. 123:1939-1951.

Rios DR, Rodrigues ET, Cardoso AP, Montes MB, Franceschini SA and Toloi MR. (2008). Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women. Nutrition. 24:1153-1158. crossref(new window)

Uesugi T, Toda T, Tsuji K and Ishida H. (2001). Comparative study on reduction of bone loss and lipid metabolism abnormality in ovariectomized rats by soy isoflavones, daidzin, genistin, and glycitin. Biological and Pharmaceutical Bulletin. 24:368-372. crossref(new window)