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Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice
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 Title & Authors
Inhibitory Effect of Chaenomeles sinensis Fruit on Amyloid β Protein (25-35)-Induced Neurotoxicity in Cultured Neurons and Memory Impairment in Mice
Jung, Myung-Hwan; Song, Kyung-Sik; Seong, Yeon-Hee;
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The present study investigated an ethanol extract of Chaenomeles sinensis fruit (CSF) for possible neuroprotective effects on neurotoxicity induced by amyloid protein () (25-35) in cultured rat cortical neurons and also for antidementia activity in mice. Exposure of cultured cortical neurons to (25-35) for 36 h induced neuronal apoptotic death. At , CSF inhibited neuronal death, elevation of intracellular calcium concentration (), and generation of reactive oxygen species (ROS) induced by (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of mice with 15 nmol (25-35) was inhibited by chronic treatment with CSF (10, 25 and 50 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. CSF (50 mg/kg) inhibited the increase of cholinesterase activity in (25-35)-injected mice brain. From these results, we suggest that the antidementia effect of CSF is due to its neuroprotective effect against (25-35)-induced neurotoxicity and that CSF may have a therapeutic role for preventing the progression of Alzheimer`s disease.
Chaenomeles sinensis Fruit;Neuroprotection;Amyloid Protein;Cultured Neurons;Memory Impairment;
 Cited by
머루전초, 독활전초, 감초 혼합추출물의 Amyloid β Protein (25-35) 유발 신경 독성에 대한 억제효과,장지연;성연희;

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