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Effect of Dendrobium loddigesii Rolfe Methanol Extract on Melanogenesis in α-MSH Stimulated B16F10 Cells
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 Title & Authors
Effect of Dendrobium loddigesii Rolfe Methanol Extract on Melanogenesis in α-MSH Stimulated B16F10 Cells
Jung, Ho Kyung; Jang, Ji Hun; Sim, Mi Ok; Lee, Ki Ho; Yeo, Jun Hwan; Kang, Byoung Man; Cho, Jung Hee; Bean, Chul Gu; Kim, Seong Cheol; Jung, Won Seok;
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Dendrobium loddigesii (DL) is a valuable and versatile herbal medicine with the anecdotal claims of anti-oxidant and anti-inflammation. In the present study, we investigated the whitening effects of DL under various conditions with B16F10 melanoma cells. The DL extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DL extract effectively suppressed the -MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the -MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2), microphthalmia-associated transcription factor (MITF) and protein expression of tyrosinase were significantly attenuated by DL treatment. These results indicate that DL may be a great cosmeceutical ingredient for its whitening effects.
Dendrobium loddigesii;Whitening;Melanin;Tyrosinase;
 Cited by
흰목이버섯 추출물의 미백 및 주름개선 효과,이광호;박현수;윤일주;신용봉;백영찬;구대호;김성규;정호경;심미옥;조현우;정원석;김명석;

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