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Effect of Dendrobium speciosum Var. Aqueous Extract on Loperamide-Induced Constipation in Rats
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 Title & Authors
Effect of Dendrobium speciosum Var. Aqueous Extract on Loperamide-Induced Constipation in Rats
Jang, Ji Hun; Jung, Ho Kyung; Sim, Mi Ok; An, Byeong Kwan; Kim, Min Suk; Kang, Byoung Man; Cho, Jung Hee; Bean, Chul Gu; Kim, Seong Cheol; Jung, Won Seok;
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Background : Irregular meals and insufficient exercise are major modern lifestyle-related risk factors for constipation. This study aimed to examine the effects of the aqueous extract of Dendrobium speciosum var. (DM) on the improvement of intestinal function and prevention of constipation in rats. Methods and Results : Constipation in rat was induced by loperamide (4 mg/kg) injection for 5 days and rats were randomly assigned to the following groups: normal control rats (NOR), constipated rats (LOP induced) and constipated rats supplemented with dulcolax-S (POS), DMSG, 100 mg/kg (DMSG-100), 300 mg/kg (DMSG-300) and 500 mg/kg (DMSG-500). The DMSG groups showed increments in the frequency and amount of stools compared to the LOP group. Loperamide treatment markedly reduced the water content of feces, whereas DMSG administration significantly increased fecal water contents. Moreover, DMSG improved intestinal transit speed in constipated-rats. Alcian blue staining revealed increased mucus production by crypt cells and mucus contents in feces and the mucosal surface. Conclusions : In summary, DM extraction significantly improves intestinal function in rats, which indicates the effectiveness of this extract in the prevention and treatment of constipation.
Dendrobium speciosum;Alcian Blue Staining;Constipation;Laxative;Loperamide;
 Cited by
Loperamide로 유도된 변비모델에서 Lactobacillus casei에 의해 발효된 볶은 결명자 물 추출물의 효과,노종현;정호경;이무진;장지훈;심미옥;정자균;이기호;안병관;조정희;장민철;용주현;조현우;

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