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Anti-Oxidant Activity and Anti-Inflammatory Effects of Spiraea fritschiana Schneid Extract
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 Title & Authors
Anti-Oxidant Activity and Anti-Inflammatory Effects of Spiraea fritschiana Schneid Extract
Choi, Eun Yeong; Heo, Seong Il; Kwon, Yong Soo; Kim, Myong Jo;
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 Abstract
Background : We studied the anti-oxidant activity and anti-inflammatory effects of Spiraea fritschiana Schneid extract (SFSE). Methods and Results : The SFSE was prepared using methanol and was evaluated for its total phenol and flavonoid content, DPPH (1,1-diphenyl-2-picrylhydrazyl) free-radical scavenging activity, reducing power, and effect on nitric oxide (NO) production, and cell viability by using real-time polymerase chain reaction (PCR). The total phenol content was c acid equivalent (GAE)/mg and the total flavonoid content was equivalent (QE)/mg. The extract showed antioxidant activity (DPPH free-radical scavenging activity) with value of . The reducing power of the extract was Abs 0.58 at . Cell viability was determined using the MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. To evaluate anti-inflammatory activity, we examined the inhibitory effects on lipopolysaccharide-(LPS)-induced NO production in RAW 264.7 cells. The NO inhibition rate was 90% at SFSE. At the same concentration, the expression of pro-inflammatory genes such as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 also decreased. Conclusions : Our results suggest that SFSE is a novel resource for the development of foods and drugs that possess anti-oxidant and anti-inflammatory activity.
 Keywords
Spiraea fritschiana Schneid;Anti-Inflammatory;Anti-Oxidant;Lipopolysaccharide;RAW 264.7 Cells;
 Language
Korean
 Cited by
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한국자원식물학회지, 2016. vol.29. 5, pp.539-546 crossref(new window)
2.
발효옻 추출물의 헬리코박터파이로리 생장억제 및 항염증 활성,최은영;석기태;최한석;김명곤;권용수;김명조;

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Antioxidant Activity, Total Phenolics, Vitamin C and Sugar Content during Fruit Ripening of Five Different Jujube Cultivars, Korean Journal of Plant Resources, 2016, 29, 5, 539  crossref(new windwow)
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