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Whitening and Anti-Wrinkle Effects of Tremella Fuciformis Extracts
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 Title & Authors
Whitening and Anti-Wrinkle Effects of Tremella Fuciformis Extracts
Lee, Kwang Ho; Park, Hyun Soo; Yoon, Il Joo; Shin, Young Bong; Baik, Young Chan; Kooh, Dae Ho; Kim, Sung Kew; Jung, Ho Kyung; Sim, Mi Ok; Cho, Hyun Woo; Jung, Won Seok; Kim, Myoung Seok;
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Background : The white jelly mushroom (Tremella fuciformis), one of the most popular edible fungi, has medicinal properties. However, the effects of T. fuciformis in skin whitening or anti-wrinkle efficacy has not been defined to date. The aim of the present study was to investigate the effects of T. fuciformis extracts on whitening and anti-wrinkle efficacy in skin cells. Methods and Results :We prepared T. fuciformis extracts with water. The extracts () contained 12.11 mg/g polyphenol and 8.54 mg/g flavonoid concentration. T. fuciformis extracts markedly decreased melanin contents and tyrosinase activity in -MSH-stimulated melanocytes (B16F10 cells). In addition, the mRNA expression of melanin formation factors, such as microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase-related protein-2 (TRP-2) were significantly down-regulated in -MSH-stimulated melanocyte. Furthermore, T. fuciformis extracts increased the synthesis of type I procollagen and reduced mRNA expression of matrix metalloproteinase 1 (MMP-1) in the human dermal fibroblast (HDFn cells). These data indicated that T. fuciformis extracts induce repression of cellular melanogenesis and protect against wrinkles caused by UVB-stimulated damage. Conclusions : Thus T. fuciformis extracts could be a cosmetic candidate for skin whitening and anti-wrinkle effects.
Tremella fuciformis;Anti-Wrinkle;Collagen;Melanin;Natural Product;Whitening;
 Cited by
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