Advanced SearchSearch Tips
The Anti-Diabetic Effects and Nephroprotective Effect of Black Ginseng Prosapogenin Extract in Streptozotocin-Induced Mice
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
The Anti-Diabetic Effects and Nephroprotective Effect of Black Ginseng Prosapogenin Extract in Streptozotocin-Induced Mice
Kong, Ryong; Shon, Mi Yae; Seo, Yun Soo; Kang, Ok Hwa; Zhou, Tian; Kim, Do Yeon; Choi, Sung Hoon; Kwon, Dong Yeul;
  PDF(new window)
Background: This study examined the hypoglycemic and kidney protective effect of black ginseng in streptozotocin-induced diabetic mice. Methods and Results: Diabetes was induced by treating mice with streptozotocin (STZ) for four weeks. In vivo studies were performed in order to investigate the hypoglycemic effect of the black ginseng prosapogenin (GBG05-FF) extract. The body weight and blood glucose level were measured. Moreover, after the mice were sacrificed, the kidneys were isolated and histological changes were observed with hematoxylin and eosin staining. Blood urea nitrogen and creatinine levels were also measured. The results showed that administration of black ginseng increased body weight. Compared to blood glucose levels in STZ mice, blood glucose levels were reduced by 48% in STZ mice supplemented with 300 mg/kg of black ginseng, and by 69% in STZ mice supplemented with 900 mg/kg. Furthermore, histopathological examination of STZ mouse kidneys revealed, changes in the kidneys, epithelial cell damages, inflammatory cell infiltration and glomerulus hypertrophy. However, a significant reduction of glomerular water droplets (indicative of glomerulus hypertrophy) was observed in the kidneys of STZ mice supplemented with black ginseng extract. Conclusions: These results suggest that black prosapogenin (GBG05-FF) ginseng extract has a significant hypoglycemic effect and can be used as an anti-diabetic substance and renal protective agents as part of dietary supplements or novel drugs.
Black Ginseng;Diabetes;Hypoglycemic Action;Kidney Protection;
 Cited by
Allen PJ. (2012). Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value? Neuroscience and Biobehavioral Reviews. 36:1442-1462. crossref(new window)

Al-Malki AL and El Rabey HA. (2015). The antidiabetic effect of low doses of Moringa oleifera Lam. seeds on streptozotocin induced diabetes and diabetic nephropathy in male rats. BioMed Research International. 2015:381040. by 2015 Jan 5).

Asgari E, Le Friec G, Yamamoto H, Perucha E, Sacks SS, Khl J, Cook HT and Kemper C. (2013). C3a modulates IL-1${\beta}$ secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood. 122:3473-3481. crossref(new window)

Baek NI, Kim DS, Lee YH, Park JD, Lee CB and Kim SI. (1996). Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng. Planta Medica. 62:86-87. crossref(new window)

Beppu H, Maruta K, Krner T and Kolb H. (1987). Diabetogenic action of streptozotocin: Essential role of membrane permeability. Acta Endocrinologica. 114:90-95.

Dobrzynski E, Montanari D, Agata J, Zhu J, Chao J and Chao L. (2002). Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats. American Journal of Physiology. Endocrinology and Metabolism. 283:E1291-E1298. crossref(new window)

Forbes JM and Cooper ME. (2013). Mechanisms of diabetic complications. Physiological Reviews. 93:137-188. crossref(new window)

Gong SE, Yoon IJ, Heo DS and Oh MS. (2007). Study of Oriental medical science documentory records of "So-gal". Journal of Daejeon University Institute of Oriental Medicine. 16:107-114.

Grover JK, Vats V, Rathi SS and Dawar R. (2001). Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. Journal of Ethnopharmacology. 76:233-238. crossref(new window)

Hewitt SM, Dear J and Star RA. (2004). Discovery of protein biomarkers for renal diseases. Journal of the American Society of Nephrology. 15:1677-1689. crossref(new window)

Kim AJ, Yoo HS and Kang SJ. (2012). Ameliorative effect of black ginseng on diabetic complications in C57BLKS/J-db/db mice. Korean Journal of Food Science and Nutrition. 25:99-104. crossref(new window)

Kim KT, Yoo KM, Lee JW, Eom SH, Hwang IK and Lee CY. (2007a). Protective effect of steamed American ginseng(Panax quinquefolius L.) on V79-4 cells induced by oxidative stress. Journal of Ethnopharmacology. 111:443-450. crossref(new window)

Kim SJ and Kim AK. (2015). Anti-breast cancer activity of fine black ginseng(Panax ginseng Meyer) and ginsenoside Rg5. Journal of Ginseng Research. 39:125-134. crossref(new window)

Kim SN and Kang SJ. (2009). Effects of black ginseng(9 timessteaming ginseng) on hypoglycemic action and changes in the composition of ginsenosides on the steaming process. Korean Journal of Food Science and Technology. 41:77-81.

Kim SN, Ha YW, Shin H, Son SH, Wu SJ and Kim YS. (2007b). Simultaneous quantification of 14 ginsenosides in Panax ginseng C. A. Meyer(Korean red ginseng) by HPLCELSD and its application to quality control. Journal of Pharmaceutical and Biomedical Analysis. 45:164-170. crossref(new window)

Lee MR, Yun BS, In OH and Sung CK. (2011). Comparative study of Korean white, red, and black ginseng extract on cholinesterase inhibitory activity and cholinergic function. Journal of Ginseng Research. 35:421-428. crossref(new window)

Oh TW, Kang SY and Park YH. (2013). Histological analysis of five organs in streptozotocin-induced diabetic rats. Korean Journal of Herbology. 28:39-45.

Park HJ, Shim HS, Kim KS and Shim I. (2011). The protective effect of black ginseng against transient focal ischemia-induced neuronal damage in rats. Korean Journal of Physiology and Pharmacology. 15:333-338. crossref(new window)

Renno WM, Abdeen S, Alkhalaf M and Asfar S. (2008). Effect of green tea on kidney tubules of diabetic rats. British Journal of Nutrition. 100:652-659. crossref(new window)

Song JC, Kim SU, Chae SA and Eom DM. (2012). A review on thirst disease prescription in “Sikryochanyo”. The Journal of Korean Medical Classics. 25:39-49.

The Textbook Compilation Committee of Pharmacology of Herb. (2006). Pharmacology. Dongmyeong Publishers. Paju, Korea. p.773-775.

Triantafilou K, Hughes TR, Triantafilou M and Morgan BP. (2013). The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. Journal of Cell Science. 126:2903-2913. crossref(new window)

Tuomilehto J, Borch-Johnsen K, Molarius A, Forsn T, Rastenyte D, Sarti C and Reunanen A. (1998). Incidence of cardiovascular disease in Type 1(insulin-dependent) diabetic subjects with and without diabetic nephropathy in Finland. Diabetologia. 41:784-790. crossref(new window)

Vlassara H and Uribarri J. (2014). Advanced glycation end products(AGE) and diabetes: Cause, effect, or both? Current Diabetes Reports. 14:453. by 2015 Dec 21). crossref(new window)

Wolf G and Ziyadeh FN. (1999). Molecular mechanisms of diabetic renal hypertrophy. Kidney International. 56:393-405. crossref(new window)

Yun TK. (1996). Experimental and epidemiological evidence of the cancer-preventive effects of Panax ginseng C. A. Meyer. Nutrition reviews. 54:S71-81.

Yun TK. (2003). Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds. Mutation Research. 523-524:63-74. crossref(new window)