JOURNAL BROWSE
Search
Advanced SearchSearch Tips
The Spermatogenic Effect of Yacon Extract and Its Constituents and Their Inhibition Effect of Testosterone Metabolism
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Biomolecules & Therapeutics
  • Volume 21, Issue 2,  2013, pp.153-160
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2012.093
 Title & Authors
The Spermatogenic Effect of Yacon Extract and Its Constituents and Their Inhibition Effect of Testosterone Metabolism
Park, Jeong Sook; Han, Kun;
  PDF(new window)
 Abstract
We screened the pharmacological effects of a 50% ethanol extract of Yacon tubers and leaves on spermatogenesis in rats. As a result, we found that Yacon tuber extracts increased sperm number and serum testosterone level in rats. It has been reported that the crude extract of Yacon tubers and leaves contain phenolic acids, such as, chlorogenic acid, ferulic acid and caffeic acid by HPLC/MS analysis. We were interested in the contributions made by phenolic acid, particularly chlorogenic acid of Yacon tuber extract to the spermatogenic activity. After administering Yacon tuber extract or chlorogenic acid to rats for 5 weeks, numbers of sperm in epididymis were increased by 34% and 20%, respectively. We also administered ferulic acid, which has been reported to be a metabolite of chlorogenic acid and a constituent of Yacon tuber extract to investigate its spermatogenic activity in rats. Yacon tuber extract and ferulic acid increased sperm numbers by 43% and 37%, respectively. And, Yacon tuber extract, and chlorogenic acid showed significantly inhibition effect of testoeterone degradation in rat liver homogenate. We considered that the spermatogenic effect of Yacon tuber extract might be related to phenolic compounds and their inhibitory effect of testosterone degradation. Yacon showed the possibility as ameliorable agents of infertility by sperm deficiency and late onset hypogonadism syndrome with low level of testosterone.
 Keywords
Smallanthus sonchifolius;Sperm;Spermatogenesis;Chlorogenic acid;Testosterone;
 Language
English
 Cited by
1.
Effects of enzymatic hydrolysate from seahorse Hippocampus abdominalis on testosterone secretion from TM3 Leydig cells and in male mice,;;;;;;

Applied Biological Chemistry, 2016. vol.59. 6, pp.869-879 crossref(new window)
1.
Ferulic acid prevents lead-induced testicular oxidative stress and suppressed spermatogenesis in rats, Andrologia, 2017, e12798  crossref(new windwow)
2.
A Review on Plants Used for Improvement of Sexual Performance and Virility, BioMed Research International, 2014, 2014, 1  crossref(new windwow)
3.
Phenolic profile and antioxidant activity of extracts of leaves and flowers of yacon (Smallanthus sonchifolius), Industrial Crops and Products, 2014, 62, 499  crossref(new windwow)
4.
The effect of red wine consumption on hormonal reproductive parameters and total antioxidant status in young adult male rats, Food & Function, 2014, 5, 9, 2096  crossref(new windwow)