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Lipid A as a Drug Target and Therapeutic Molecule
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  • Journal title : Biomolecules & Therapeutics
  • Volume 23, Issue 6,  2015, pp.510-516
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2015.117
 Title & Authors
Lipid A as a Drug Target and Therapeutic Molecule
Joo, Sang Hoon;
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In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.
Lipid A;Endotoxin;Drug target;Antibacterial;Adjuvant;
 Cited by
Functionalized lipids and surfactants for specific applications, Biochimica et Biophysica Acta (BBA) - Biomembranes, 2016, 1858, 10, 2362  crossref(new windwow)
Antivirals against animal viruses, Biochemical Pharmacology, 2017, 133, 97  crossref(new windwow)
Tandem mass spectrometry determination of the putative structure of a heterogeneous mixture of Lipid Asisolated from the lipopolysaccharide of the Gram-negative bacteriaAeromonas liquefaciensSJ-19a, Rapid Communications in Mass Spectrometry, 2016, 30, 8, 1043  crossref(new windwow)