Advanced SearchSearch Tips
Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Biomolecules & Therapeutics
  • Volume 23, Issue 6,  2015, pp.597-603
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2015.057
 Title & Authors
Neurotoxicity of Synthetic Cannabinoids JWH-081 and JWH-210
Cha, Hye Jin; Seong, Yeon-Hee; Song, Min-Ji; Jeong, Ho-Sang; Shin, Jisoon; Yun, Jaesuk; Han, Kyoungmoon; Kim, Young-Hoon; Kang, Hoil; Kim, Hyoung Soo;
  PDF(new window)
Synthetic cannabinoids JWH-018 and JWH-250 in 'herbal incense' also called 'spice' were first introduced in many countries. Numerous synthetic cannabinoids with similar chemical structures emerged simultaneously and suddenly. Currently there are not sufficient data on their adverse effects including neurotoxicity. There are only anecdotal reports that suggest their toxicity. In the present study, we evaluated the neurotoxicity of two synthetic cannabinoids (JWH-081 and JWH-210) through observation of various behavioral changes and analysis of histopathological changes using experimental mice with various doses (0.1, 1, 5 mg/kg). In functional observation battery (FOB) test, animals treated with 5 mg/kg of JWH-081 or JWH-210 showed traction and tremor. Their locomotor activities and rotarod retention time were significantly (p<0.05) decreased. However, no significant change was observed in learning or memory function. In histopathological analysis, neural cells of the animals treated with the high dose (5 mg/kg) of JWH-081 or JWH-210 showed distorted nuclei and nucleus membranes in the core shell of nucleus accumbens, suggesting neurotoxicity. Our results suggest that JWH-081 and JWH-210 may be neurotoxic substances through changing neuronal cell damages, especially in the core shell part of nucleus accumbens. To confirm our findings, further studies are needed in the future.
Synthetic cannabinoid;Neurotoxicity;Functional observation battery;Motor function;Histopathology;
 Cited by
Pharmaco-toxicological effects of the novel third-generation fluorinate synthetic cannabinoids, 5F-ADBINACA, AB-FUBINACA, and STS-135 in mice. In vitro and in vivo studies, Human Psychopharmacology: Clinical and Experimental, 2017, 32, 3, e2601  crossref(new windwow)
Buzz Juice: Neurological sequelae of synthetic cannabinoids, Journal of Clinical Neuroscience, 2017, 37, 43  crossref(new windwow)
Cannabinoïdes de synthèse : une nouvelle matrice des addictions, La Presse Médicale, 2017, 46, 1, 11  crossref(new windwow)