Advanced SearchSearch Tips
Alpha-Ketoglutarate: Physiological Functions and Applications
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
  • Journal title : Biomolecules and Therapeutics
  • Volume 24, Issue 1,  2016, pp.1-8
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2015.078
 Title & Authors
Alpha-Ketoglutarate: Physiological Functions and Applications
Wu, Nan; Yang, Mingyao; Gaur, Uma; Xu, Huailiang; Yao, Yongfang; Li, Diyan;
  PDF(new window)
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits protein degradation in muscles. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles and can be used in clinical applications. In addition to these health benefits, a recent study has shown that AKG can extend the lifespan of adult Caenorhabditis elegans by inhibiting ATP synthase and TOR. AKG not only extends lifespan, but also delays age-related disease. In this review, we will summarize the advances in AKG research field, in the content of its physiological functions and applications.
Alpha-ketoglutarate;Functions;Lifespan extension;Applications;
 Cited by
Alpha-ketoglutarate enhances milk protein synthesis by porcine mammary epithelial cells, Amino Acids, 2016, 48, 9, 2179  crossref(new windwow)