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Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis
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  • Journal title : Biomolecules & Therapeutics
  • Volume 24, Issue 1,  2016, pp.19-24
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2015.066
 Title & Authors
Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis
Zhang, Jianying; Gao, Caihua; Meng, Meijuan; Tang, Hongxia;
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 Abstract
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The exploration of new biomarkers with high sensitivity and specificity for early diagnosis of AMI therefore becomes one of the primary task. In the current study, we aim to detect whether there is any heart specific long noncoding RNA (lncRNA) releasing into the circulation during AMI, and explore its function in the neonatal rat cardiac myocytes injury induced by . Our results revealed that the cardiac-specific lncRNA MHRT (Myosin Heavy Chain Associated RNA Transcripts) was significantly elevated in the blood from AMI patients compared with the healthy control (<). Using an in vitro neonatal rat cardiac myocytes injury model, we demonstrated that lncRNA MHRT was upregulated in the cardiac myocytes after treatment with hydrogen peroxide () via real-time RT-PCR (qRT-PCR). Furthermore, we knockdowned the MHRT gene by siRNA to confirm its roles in the -induced cardiac cell apoptosis, and found that knockdown of MHRT led to significant more apoptotic cells than the non-target control (<), indicating that the lncRNA MHRT is a protective factor for cardiomyocyte and the plasma concentration of MHRT may serve as a biomarker for myocardial infarction diagnosis in humans AMI.
 Keywords
Acute myocardial infarction;Long noncoding RNAs;MHRT;Apoptosis;
 Language
English
 Cited by
1.
Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure, Journal of Cellular and Molecular Medicine, 2017  crossref(new windwow)
2.
Long noncoding RNAs (LncRNAs) — The dawning of a new treatment for cardiac hypertrophy and heart failure, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017  crossref(new windwow)
3.
Regulatory non-coding RNAs in acute myocardial infarction, Journal of Cellular and Molecular Medicine, 2017, 21, 5, 1013  crossref(new windwow)
4.
Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering, Engineering, 2017, 3, 1, 3  crossref(new windwow)
5.
Knockdown of Long Non-Coding RNA-ZFAS1 Protects Cardiomyocytes Against Acute Myocardial Infarction Via Anti-Apoptosis by Regulating miR-150/CRP, Journal of Cellular Biochemistry, 2017  crossref(new windwow)
6.
Emerging roles and mechanisms of long noncoding RNAs in atherosclerosis, International Journal of Cardiology, 2017, 228, 570  crossref(new windwow)