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Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents
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  • Journal title : Biomolecules and Therapeutics
  • Volume 24, Issue 1,  2016, pp.67-74
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2015.070
 Title & Authors
Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents
Lee, Ju Hee; Sun, Ya Nan; Kim, Young Ho; Lee, Sang Kook; Kim, Hyun Pyo;
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 Abstract
In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O--D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL--treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.
 Keywords
Acantopanax divaricatus var. albeofructus;Lung inflammation;Acanthoside;Macrophage;
 Language
English
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