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Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells
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  • Journal title : Biomolecules and Therapeutics
  • Volume 24, Issue 1,  2016, pp.75-84
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2015.069
 Title & Authors
Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells
Fernando, Pattage Madushan Dilhara Jayatissa; Piao, Mei Jing; Kang, Kyoung Ah; Ryu, Yea Seong; Hewage, Susara Ruwan Kumara Madduma; Chae, Sung Wook; Hyun, Jin Won;
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 Abstract
This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuated UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increased the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. Collectively, these data indicate that RA can provide substantial cytoprotection against the adverse effects of UVB radiation by modulating cellular antioxidant systems, and has potential to be developed as a medical agent for ROS-induced skin diseases.
 Keywords
Antioxidant system;Oxidative stress;Reactive oxygen species;Rosmarinic acid;Ultraviolet B;
 Language
English
 Cited by
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Polyphenolic contents and antioxidant activities of two medicinal plant species, Mentha piperita and Stevia rebaudiana, cultivated in Iran, Comparative Clinical Pathology, 2016, 25, 4, 743  crossref(new windwow)
3.
Efficacy of Pre- and Post-Treatment by Topical Formulations Containing Dissolved and Suspended Silybum marianum against UVB-Induced Oxidative Stress in Guinea Pig and on HaCaT Keratinocytes, Molecules, 2016, 21, 10, 1269  crossref(new windwow)
4.
Skin-Derived Precursors against UVB-Induced Apoptosis via Bcl-2 and Nrf2 Upregulation, BioMed Research International, 2016, 2016, 1  crossref(new windwow)