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Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats
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  • Journal title : Biomolecules and Therapeutics
  • Volume 24, Issue 2,  2016, pp.171-177
  • Publisher : The Korean Society of Applied Pharmacology
  • DOI : 10.4062/biomolther.2015.089
 Title & Authors
Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats
Choi, Hye-Kyung; Won, Eun-Kyung; Choung, Se-Young;
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 Abstract
Statins, HMG-CoA reductase inhibitors, are known to cause serious muscle injuries (e.g. myopathy, myositis and rhabdomyolysis), and these adverse effects can be rescued by co-administration of coenzyme () with statins. The goal of the current research is to assess the efficacy of combined treatment of with Atorvastatin for hyperlipidemia induced by high-fat diet in SD rats. 4-week-old Sprague-Dawley male rats were fed normal diet or high-fat diet for 6 weeks. Then, rats were treated with either Statin or Statin with various dosages of (30, 90 or 270 mg/kg/day, p.o.) for another 6 weeks. Compared to Statin only treatment, supplementation significantly reduced creatine kinase and aspartate aminotransferase levels in serum which are markers for myopathy. Moreover, supplementation with Statin further reduced total fat, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol. In contrast, the levels of high-density lipoprotein-cholesterol and were increased in the co-treated group. These results indicate that treatment not only reduces the side effects of Statin, but also has an anti-obesity effect. Therefore an intake of supplementary is helpful for solving problem of obese metabolism, so the multiple prescription of makes us think a possibility that can be solved in being contiguous to the obesity problem, a sort of disease of the obese metabolism.
 Keywords
Statins;Coenzyme ;Hyperlipidemia;HMG-CoA reductase;Myopathy;
 Language
English
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