Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats

• Journal title : Biomolecules and Therapeutics
• Volume 24, Issue 2,  2016, pp.171-177
• Publisher : The Korean Society of Applied Pharmacology
• DOI : 10.4062/biomolther.2015.089
Title & Authors
Effect of Coenzyme Q10 Supplementation in Statin-Treated Obese Rats
Choi, Hye-Kyung; Won, Eun-Kyung; Choung, Se-Young;

Abstract
Statins, HMG-CoA reductase inhibitors, are known to cause serious muscle injuries (e.g. myopathy, myositis and rhabdomyolysis), and these adverse effects can be rescued by co-administration of coenzyme $\small{Q_{10}}$ ($\small{CoQ_{10}}$) with statins. The goal of the current research is to assess the efficacy of combined treatment of $\small{CoQ_{10}}$ with Atorvastatin for hyperlipidemia induced by high-fat diet in SD rats. 4-week-old Sprague-Dawley male rats were fed normal diet or high-fat diet for 6 weeks. Then, rats were treated with either Statin or Statin with various dosages of $\small{CoQ_{10}}$ (30, 90 or 270 mg/kg/day, p.o.) for another 6 weeks. Compared to Statin only treatment, $\small{CoQ_{10}}$ supplementation significantly reduced creatine kinase and aspartate aminotransferase levels in serum which are markers for myopathy. Moreover, $\small{CoQ_{10}}$ supplementation with Statin further reduced total fat, triglycerides, total cholesterol, and low-density lipoprotein-cholesterol. In contrast, the levels of high-density lipoprotein-cholesterol and $\small{CoQ_{10}}$ were increased in the $\small{CoQ_{10}}$ co-treated group. These results indicate that $\small{CoQ_{10}}$ treatment not only reduces the side effects of Statin, but also has an anti-obesity effect. Therefore an intake of supplementary $\small{CoQ_{10}}$ is helpful for solving problem of obese metabolism, so the multiple prescription of $\small{CoQ_{10}}$ makes us think a possibility that can be solved in being contiguous to the obesity problem, a sort of disease of the obese metabolism.
Keywords
Statins;Coenzyme $\small{Q_{10}}$;Hyperlipidemia;HMG-CoA reductase;Myopathy;
Language
English
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