Advanced SearchSearch Tips
Aging-Related Changes in Hand Intrinsic and Extrinsic Muscles and Hand Dexterity : an MRI Investigation
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Aging-Related Changes in Hand Intrinsic and Extrinsic Muscles and Hand Dexterity : an MRI Investigation
Hsu, Jeffrey; Koh, Kyung; Park, Yang-Sun; Kwon, Hyun-Joon; Kim, Yoon-Hyuk; Shin, Joon-Ho; Shim, Jae-Kun;
  PDF(new window)
Object : The purpose of this study was to investigate aging-related changes of intrinsic and extrinsic hand muscles in their strength, cross-sectional area and volume, force control, and multi-digit synergies. It was hypothesized that aging would negatively affect distal muscles (intrinsic muscles) more than proximal muscles (extrinsic muscles). Method : Nine young and eleven older right-handed participants underwent MRI scans of the hand and forearm. Muscle cross-sectional areas and volumes of the intrinsic and extrinsic hand muscles were determined. Result : Muscle volume of the intrinsic muscles were larger in the younger group than the older group while muscle volume of the extrinsic muscles did not differ. For the cross-sectional area, both the intrinsic and extrinsic muscles of the younger group were larger than the older group. The maximum strength of the intrinsic muscles of the young group was 31% greater than the older group ( vs , p < 0.05) while the extrinsic muscles showed no significant difference. Although the elderly group showed a trend of decreased force control and multi-digit synergies, no statistical differences were found. These findings indicate aging-related decreases in hand muscle size and strength affect intrinsic muscles more than extrinsic muscles, thus supporting the hypothesis that sarcopenia affects the muscle size and strength of distal muscles more than proximal muscles. Conclusion : The aging-related decreases in hand muscle size and function were more apparent in intrinsic hand muscles, located more distally, than extrinsic muscles, located more proximally.
Aging;Intrinsic Hand Muscle;Extrinsic Hand Muscle;MRI;
 Cited by
Anakwe, R. E., Huntley, J. S., & McEachan, J. E. (2007). Grip strength and forearm circumference in a healthy population. Journal of Hand Surgery, 32(2), 203-209. doi: S0266-7681(06)00485-2[pii]10.1016/j.jhsb.2006.11.003 crossref(new window)

Association., A. C. o. S. M. P. S. a. A. H. (1998). Recommendations for cardiovascular screening, staffing, and emergency policies at health/fitness facilities. Medicine & Science in Sports & Exercise, 30(6), 9.

Brown, W. F. (1972). A method for estimating the number of motor units in thenar muscles and the changes in motor unit count with ageing. Journal of Neurology, Neurosurgery & Psychiatry, 35(6), 845-852. crossref(new window)

Carmeli, E., Patish, H., & Coleman, R. (2003). The aging hand. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 58(2), 146-152. crossref(new window)

Christ, C. B., Boileau, R. A., Slaughter, M. H., Stillman, R. J., Cameron, J. A., & Massey, B. H. (1992). Maximal Voluntary isometric force production characteristics of six muscle groups in women aged 25 to 74 years. American Journal of Human Biology, 4, 537-545. crossref(new window)

Chumlea, W. C., Guo, S. S., Zeller, C. M., Reo, N. V., & Siervogel, R. M. (1999). Total body water data for white adults 18 to 64 years of age: the Fels Longitudinal Study. Kidney International, 56(1), 244-252. doi: kid532 [pii] 10.1046/j.1523-1755.1999.00532.x crossref(new window)

De, M., Sanford, T. R., & Wood, G. W. (1992). Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrouscycle and are induced by estrogen and progesterone. Developmental Biology, 151(1), 297-305. crossref(new window)

Doherty, T. J. (2003). Invited review: Aging and sarcopenia. Journal of Applied Physiology, 95(4), 1717-1727. crossref(new window)

Doherty, T. J., & Brown, W. F. (1997). Age-related changes in the twitch contractile properties of human thenar motor units. Journal of Applied Physiology, 82(1), 93-101. crossref(new window)

Doherty, T. J., Vandervoort, A. A., Taylor, A. W., & Brown, W. F. (1993). Effects of motor unit losses on strength in older men and women. Journal of Applied Physiology, 74(2), 868-874. crossref(new window)

Eng, C. M., Abrams, G. D., Smallwood, L. R., Lieber, R. L., & Ward, S. R.(2007). Muscle geometry affects accuracy of forearm volume determination by magnetic resonance imaging (MRI). Journal of Biomechanics, 40(14), 3261-3266. crossref(new window)

Evans, W. J. (1995). Exercise, nutrition, and aging. Clinics in Geriatric Medicine, 11(4), 725-734. crossref(new window)

Frontera, W. R., Hughes, V. A., Lutz, K. J., & Evans, W. J. (1991). A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women. Journal of Applied Physiology, 71(2), 644-650. crossref(new window)

Galea, V. (1996). Changes in motor unit estimates with aging. Journal of Clinical Neurophysiology, 13(3), 253-260. crossref(new window)

Galganski, M. E., Fuglevand, A. J., & Enoka, R. M. (1993). Reduced control of motor output in a human hand muscle of elderly subjects during submaximal contractions. Journal of Neurophysiology, 69(6), 2108-2115. crossref(new window)

Hackel, M. E., Wolfe, G. A., Bang, S. M., & Canfield, J. S. (1992). Changes in hand function in the aging adult as determined by the Jebsen Test of Hand Function. Physical Therapy, 72(5), 373-377. crossref(new window)

Harding, D. C., Brandt, K. D., & Hillberry, B. M. (1993). Finger joint force minimization in pianists using optimization techniques. Journal of Biomechanics, 26(12), 1403-1412. crossref(new window)

Heymsfield, S. B., Wang, Z., Baumgartner, R. N., Dilmanian, F. A., Ma, R., & Yasumura, S. (1993). Body composition and aging: a study by in vivo neutron activation analysis. Journal of Nutrition, 123(2Suppl), 432-437. crossref(new window)

Holzbaur, K. R., Murray, W. M., Gold, G. E., & Delp, S. L. (2007). Upper limb muscle volumes in adult subjects. Journal of Biomechanics, 40(4), 742-749. doi: S0021-9290(06)00442-8[pii]10.1016/j.jbiomech.2006.11.011 crossref(new window)

Hummel, F., Celnik, P., Giraux, P., Floel, A., Wu, W. H., Gerloff,C., & Cohen, L. G. (2005). Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain, 128 (Pt 3), 490-499. doi: awh369[pii]10.1093/brain/awh369 crossref(new window)

Imrhan, S. N., & Loo, C. H. (1989). Trends in finger pinch strength in children, adults, and the elderly. Human Factors, 31(6), 689-701. crossref(new window)

Jebsen, R. H., Taylor, N., Trieschmann, R. B., Trotter, M. J., & Howard, L. A. (1969). An objective and standardized test of hand function. Archives of Physical Medicine and Rehabilitation, 50(6), 311-319.

Jubrias, S. A., Odderson, I. R., Esselman, P. C., & Conley, K. E. (1997). Decline in isokinetic force with age: muscle cross-sectional area and specific force. Pflügers Archiv, 434(3), 246-253. crossref(new window)

Kallman, D. A., Plato, C. C., & Tobin, J. D. (1990). The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives. Journals of Gerontology, 45(3), M82-88.

Keogh, J. W. (2006). Digit force control in older adults: Benefits of resistance-training? Ageing International, 32(3), 14.

Kim, Y. S., Park, J., Hsu, J., Cho, K. K., Kim, Y. K., & Shim, J. K. (2010). Effects of training frequency on lumbar extension strength in patients recovering from lumbar discectomy. Journal of Rehabilitation Medicine. crossref(new window)

Klein, C. S., Allman, B. L., Marsh, G. D., & Rice, C. L. (2002). Muscle size, strength, and bone geometry in the upper limbs of young and old men. Journals of Gerontology. Series A:Biological Sciences and Medical Sciences, 57(7), M455-459. crossref(new window)

Klein, C. S., Rice, C. L., & Marsh, G. D. (2001). Normalized force, activation, and coactivation in the arm muscles of young and old men. Journal of Applied Physiology, 91(3), 1341-1349. crossref(new window)

Laidlaw, D. H., Kornatz, K. W., Keen, D. A., Suzuki, S., & Enoka, R. M. (1999). Strength training improves the steadiness of slow lengthening contractions performed by old adults. Journal of Applied Physiology, 87(5), 1786-1795. crossref(new window)

Latash, M. L., Scholz, J. F., Danion, F., & Schoner, G. (2001). Structure of motor variability in marginally redundant multifinger force production tasks. Experimental Brain Research, 141(2), 153-165. doi: 10.1007/s002210100861 crossref(new window)

Lesser, G. T., & Markofsky, J. (1979). Body water compartments with human aging using fat-free mass as the reference standard. American Journal of Physiology, 236(3), R215-220.

Li, Z. M., Zatsiorsky, V. M., & Latash, M. L. (2000). Contribution of the extrinsic and intrinsic hand muscles to the moments in finger joints. Clinical Biomechanics, 15(3), 203-211. crossref(new window)

Lieber, R. L. (1986). Skeletal Muscle Adaptability I: Review of Basic Properties. Developmental Medicine & Child Neurology, (28), 7.

Long, C., 2nd, Conrad, P. W., Hall, E. A., & Furler, S. L. (1970). Intrinsic-extrinsic muscle control of the hand in power grip and precision handling. An electromyographic study. Journal of Bone and Joint Surgery, 52(5), 853-867. crossref(new window)

Lynch, N. A., Metter, E. J., Lindle, R. S., Fozard, J. L., Tobin, J. D., Roy, T. A., & Hurley, B. F. (1999). Muscle quality. I. Age-associated differences between arm and leg muscle groups. Journal of Applied Physiology, 86(1), 188-194. crossref(new window)

Macaluso, A., Nimmo, M. A., Foster, J. E., Cockburn, M., McMillan, N. C., & De Vito,G. (2002). Contractile muscle volume and agonist-antagonist coactivation account for differences in torque between young and older women. Muscle Nerve, 25(6), 858-863. doi:10.1002/mus.10113 crossref(new window)

Medicine, A. C. o. S. (2006). ACSM's Guidlines for Exercise Testing and Prescription (7th ed.): Lippincott Williams & Wilkins.

Olafsdottir, H., Yoshida, N., Zatsiorsky, V. M., & Latash, M. L. (2007). Elderly show decreased adjustments of motor synergies in preparation to action. Clinical Biomechanics, 22(1), 44-51. doi: S0268-0033(06)00162-8 [pii] 10.1016/j.clinbiomech.2006.08.005 crossref(new window)

Oldfield, R. C. (1971). The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia, 9(1),97-113. crossref(new window)

Oliveira, M. A., Hsu, J., Park, J., Clark, J. E., & Shim, J. K. (2008). Age-related changes in multi-finger interactions in adults during maximum voluntary finger force production tasks. Human Movement Science, 27(5), 714-727. crossref(new window)

Pottratz, S. T., Bellido, T., Mocharla, H., Crabb, D., & Manolagas, S. C. (1994). 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. Journal of Clinical Investigation, 93(3), 944-950. doi:10.1172/JCI117100 crossref(new window)

Ralston, S. H. (1994). Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced cytokine expression in postmenopausal osteoporosis. Journal of Bone and Mineral Research, 9(6), 883-890. doi: 10.1002/jbmr.5650090614 crossref(new window)

Rantanen, T., Masaki, K., Foley, D., Izmirlian, G., White, L., & Guralnik, J. M.(1998). Grip strength changes over 27 yr in Japanese-American men. Journal of Applied Physiology, 85(6), 2047-2053. crossref(new window)

Rice, C. L., Cunningham, D. A., Paterson, D. H., & Lefcoe, M. S. (1989). Arm and leg composition determined by computed tomography in young and elderly men. Clinical Physiology, 9(3), 207-220. crossref(new window)

Roubenoff, R., & Hughes, V. A. (2000). Sarcopenia: current concepts. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 55(12), M716-724. crossref(new window)

Schmidt, S. L., Oliveira, R. M., Rocha, F. R., & Abreu-Villaca, Y. (2000). Influences of handedness and gender on the grooved pegboard test. Brain and Cognition, 44(3), 445-454. doi: 10.1006/brcg.1999.1204 S0278262699912046[pii] crossref(new window)

Schoner, G. (1995). Recent developments and problems in human movement science and the irconceptual implications. Ecological Psychology, 7(4), 23.

Shim, J. K., Hsu, J., Karol, S., & Hurley, B. F. (2008). Strength training increases training-specific multifinger coordination in humans. Motor Control, 12(4), 311-329. crossref(new window)

Shim, J. K., Lay, B. S., Zatsiorsky, V. M., & Latash, M. L. (2004). Age-related changes in finger coordination in static prehension tasks. Journal of Applied Physiology, 97(1), 213-224. crossref(new window)

Shim, J. K., Olafsdottir, H., Zatsiorsky, V. M., & Latash, M. L. (2005). The emergence and disappearance of multi-digit synergies during force-production tasks. Experimental Brain Research, 164(2), 260-270. crossref(new window)

Shinohara, M., Latash, M. L., & Zatsiorsky, V. M. (2003). Age effects on force produced by intrinsic and extrinsic hand muscles and finger interaction during MVC tasks. Journal of Applied Physiology, 95(4), 1361-1369. crossref(new window)

Shinohara, M., Li, S., Kang, N., Zatsiorsky, V. M., & Latash, M. L. (2003). Effects of age and gender on finger coordination in MVC and submaximal force-matching tasks. Journal of Applied Physiology, 94(1), 259-270. crossref(new window)

Shinohara, M., Scholz, J. P., Zatsiorsky, V. M., & Latash, M. L. (2004). Finger interaction during accurate multi-finger force production tasks in young and elderly persons. Experimental Brain Research, 156(3), 282-292. crossref(new window)

Sosnoff, J. J., Vaillancourt, D. E., & Newell, K. M. (2004). Aging and rhythmical force output: loss of adaptive control of multiple neural oscillators. Journal of Neurophysiology, 91(1), 172-181. doi: 10.1152/jn.00613.200300613.2003[pii] crossref(new window)

Tracy, B. L., Ivey, F. M., Jeffrey Metter, E., Fleg, J. L., Siegel, E. L., & Hurley, B. F. (2003). A more efficient magnetic resonance imaging-based strategy for measuring quadriceps muscle volume. Medicine & Science in Sports & Exercise, 35(3), 425-433.doi: 10.1249/01.MSS.0000053722.53302.D6 crossref(new window)

Viitasalo, J. T., Era, P., Leskinen, A. L., & Heikkinen, E. (1985). Muscular Strength profiles and anthropometry in random samples of men aged 31-35, 51-55 and 71-75years. Ergonomics, 28, 1563-1574. crossref(new window)

Winter, D. A. (1990). Biomechanics and Motor Control of Human Movement (2 ed.). New Yoark: John Wiley &Sons Inc.