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Performance Estimation of an Implantable Epileptic Seizure Detector with a Low-power On-chip Oscillator
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 Title & Authors
Performance Estimation of an Implantable Epileptic Seizure Detector with a Low-power On-chip Oscillator
Kim, Sunhee; Choi, Yun Seo; Choi, Kanghyun; Lee, Jiseon; Lee, Byung-Uk; Lee, Hyang Woon; Lee, Seungjun;
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Implantable closed-loop epilepsy controllers require ideally both accurate epileptic seizure detection and low power consumption. On-chip oscillators can be used in implantable devices because they consume less power than other oscillators such as crystal oscillators. In this study, we investigated the tolerable error range of a lower power on-chip oscillator without losing the accuracy of seizure detection. We used 24 ictal and 14 interictal intracranial electroencephalographic segments recorded from epilepsy surgery patients. The performance variations with respect to oscillator frequency errors were estimated in terms of specificity, modified sensitivity, and detection timing difference of seizure onset using Generic Osorio Frei Algorithm. The frequency errors of on-chip oscillators were set at as the worst case. Our results showed that an oscillator error of affected both specificity and modified sensitivity by less than 3%. In addition, seizure onsets were detected with errors earlier or later than without errors and the average detection timing difference varied within less than 0.5 s range. The results suggest that on-chip oscillators could be useful for low-power implantable devices without error compensation circuitry requiring significant additional power. These findings could help the design of closed-loop systems with a seizure detector and automated stimulators for intractable epilepsy patients.
implantable biomedical devices;low power;on-chip oscillators;performance evaluation;seizure detector;
 Cited by
C.P. Young, S.F. Liang, D.W Chang, Y.C. Liao, F.Z. Shaw, and C.H. Hsieh, "A Portable Wireless Online Closed-Loop Seizure Controller in Freely Moving Rats," IEEE Trans. Instrum. Meas., vol. 60, pp. 513-521, 2011. crossref(new window)

J. Carey. Brain Facts: A Primer on the Brain and Nervous System., 2012

N.C. Bhavaraju, M.G. Frei, and I. Osorio, "Analog seizure detection and performance evaluation," IEEE Trans. Biomed. Eng., vol. 53, pp. 238-245, 2006. crossref(new window)

E. Beghi and J.W. Sander. The natural history and prognosis of epilepsy. In: J. Engel and T.A. Pedley. editors. Epilepsy, a comprehensive textbook. 2nd ed, Lippincoott, Williams & Wilkins, 2008, pp. 65-70.

H.W. Lee. Neuromodulation therapy: nonmedical, nonsurgical treatment for intractable epilepsy. In: M.D. Holmes editor, Epilepsy Topics. InTech, 2014, pp. 161-172.

S. Raghunathan, S.K. Gupta, H.S. Markandeya, K. Roy, and P.P. Irazoqui, "A hardware-algorithm co-design approach to optimize seizure detection algorithms for implantable applications," . J Neurosci Methods, vol. 193, pp. 106-117, 2010 crossref(new window)

C.C. Jouny and G.K. Bergey, "Characterization of early partial seizure onset: Frequency, complexity and entropy," Clin Neurophysiol, vol. 123, pp. 658-669, 2012 crossref(new window)

I. Osorio, M.G. Frei, and S.B. Wilkinson, "Real-time automated detection and quantitative analysis of seizures and short-term prediction of clinical onset," Epilepsia, vol. 39, pp. 615-627, 1998. crossref(new window)

A.H. Shoeb and J.V. Guttag, "Application of machine learning to epileptic seizure detection," in Proc. 27th International Conference on Machine Learning, Haifa, Israel, June 2010, pp. 975-982.

F. Mormann, R.G. Andrzejak, C.E. Elger, and K. Lehnertz, "Seizure prediction: the long and winding road," Brain, vol. 130, pp. 314-333, 2007. crossref(new window)

S. Narasimhan, H.J. Chiel, and S. Bhunia, "Ultra-low-power and robust digital-signal-processing hardware for implantable neural interface microsystems," IEEE Trans. Biomed. Circuits Syst., vol. 5, pp. 169-178, 2011. crossref(new window)

J. Kwong, Y.K. Ramadass, N. Verma, and A.P. Chandrakasan, "A 65 nm sub-microcontroller with integrated SRAM and switched capacitor DC-DC converter," IEEE J. Solid-State Circuits, vol. 44, pp. 115-126, 2009. crossref(new window)

S. Kim, "Adaptive Online Voltage Scaling Scheme Based on the Nash Bargaining Solution," ETRI J., vol. 33, pp. 407- 414, 2011. crossref(new window)

J. Bae, K. Song, H. Lee, H. Cho, and H.J. Yoo, "A lowenergy crystal-Less double-FSK sensor node transceiver for wireless body-area network," IEEE J. Solid-State Circuits, vol. 47, pp. 2678-2692, 2012. crossref(new window)

J.D. Soldera, M.T. Berens, and A. Olmos, "A temperature compensated CMOS relaxation oscillator for low power applications," in Proc. 25th Symposium on Integrated Circuits and Systems Design, Brasilia, Aug. 2012, pp. 1-4.

K. Choe, O.D. Bernal, D. Nuttman, and M. Je, "A precision relaxation oscillator with a self-clocked offset-cancellation scheme for implantable biomedical SoCs," in IEEE International Solid-State Circuits Conference-Digest of Technical Papers, 2009, San Francisco, CA, USA, Feb. 2009, pp. 402- 403,403 a.

F. Sebastiano, L.J. Breems, K.A. Makinwa, S. Drago, D.M. Leenaerts, and B. Nauta, "A low-voltage mobility-based frequency reference for crystal-less ULP radios," IEEE J. Solid- State Circuits, vol. 44, pp. 2002-2009, 2009. crossref(new window)

L. Xiaoyin, H. Hongwei, Y. Linchang, L. Luming, Z. Jianguo, Y. Anchao and M. Yu, "Epileptic seizure detection with the local field potential of anterior thalamic of rats aiming at real time application,". in Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE, Boston, MA, USA, Aug. 2011, pp. 6781-6784.

S. Ravindran, R. Cole, "Low complexity algorithms for heart rate and epileptic seizure detection," in ISABEL 2009 2nd International Symposium on Applied Sciences in Biomedical and Communication Technologies, Nov. 2009. pp. 1-5.

H.W. Lee, M.W. Youngblood, P. Farooque, X. Han, S. Jhun, W.C. Chen, I. Goncharova, K. Vives, D.D. Spencer and H. Zaveri, "Seizure localization using three-dimensional surface projections of intracranial EEG power," NeuroImage, vol. 83, pp. 616-626, 2013. crossref(new window)

H.W. Lee, J. Arora, X. Papademetris, F. Tokoglu, M. Negishi, D. Scheinost, P. Farooque, H. Blumenfeld, D.D. Spencer and R.T. Constable, "Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity," Neurology, vol. 83, pp. 2269-2277, 2014. crossref(new window)

M.T. Salam, M. Sawan, and D.K. Nguyen, "A novel lowpower- implantable epileptic seizure-onset detector," IEEE Trans. Biomed. Circuits Syst., vol. 5, pp. 568-578, 2011. crossref(new window)