JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Improved Manufacturing Method of Discoidal Nanoparticles for Cancer Theranostics
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Improved Manufacturing Method of Discoidal Nanoparticles for Cancer Theranostics
BAE, J.Y.; OH, E.S.; LEE, H.; KEY, Jaehong;
  PDF(new window)
 Abstract
Nanoparticles have been studied as therapeutic and imaging agents for the early detection and cure of cancer, Cancer Theranostics. Nanoparticles were considered to effectively target cancer cells due to Enhanced Permeability and Retention (EPR) effect and most nanoparticles have been evaluated by using spherical shapes. However, the problem that the EPR effect is not so effective for human cancer therapy was recently brought up. Therefore, in this study, we suggest novel discoidal nanoparticles to overcome this problem, focusing on their manufacturing process and quality control. Herein, we demonstrate the improved manufacturing method of discoidal nanoparticles and their potential to apply to MCF 7, human breast cancer treatment.
 Keywords
discoidal nanoparticles;shape;cancer;drug delivery;imaging;
 Language
Korean
 Cited by
 References
1.
Farokhzad, O.C. and Langer, R., "Impact of nanotechnology on drug delivery." ACS Nano, vol. 3, no. 1, pp. 16-20, 2009. crossref(new window)

2.
Jun Fang, Hideaki Nakamura and Hiroshi Maeda, "The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect." Advanced Drug Delivery Reviews, vol. 63, no. 3, pp. 136-151, 2011. crossref(new window)

3.
S.M. Moghimi, A.C. Hunter and T.L. Andresen, "Factors controlling nanoparticle pharmacokinetics: An integrated analysis and perspective." Annual Review of Pharmacology and Toxicology, vol. 52, pp. 481-503, 2012. crossref(new window)

4.
J.H. Key, Santosh Aryal, Francesco Gentile, Jeyarama S. Ananta, Meng Zhong, Melissa D. Landis and Paolo Decuzzi, "Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging.", Biomaterials, vol. 34, no. 34, pp. 5402-5410, 2013. crossref(new window)

5.
Samuel K. Lai, D. Elizabeth O'Hanlon, Suzanne Harrold, Stan T. Man, Ying-Ying Wang, Richard Cone and Justin Hanes, "Rapid transport of large polymeric nanoparticles in fresh undiluted human cucus.", Proceedings of the National Academy of Sciences of United States of America, vol. 104, no. 5, pp. 1482-1487, 2006.

6.
Jillian L. Perry, Kevin G. Reuter, Marc P. Kai, Kevin P. Herlihy, Stephen W. Jones, J. Chris Luft, Mary Napier, James E. Bear and Joseph M. DeSimone, "PEGylated PRINT nanoparticles: The impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics.", NANO letters, vol. 12, no. 10, pp. 5304-5310, 2012. crossref(new window)

7.
Jaehong Key, Anna Lisa Palange, Francesco Gentile, Santosh Aryal, Cinzia Stigliano, Daniele Di Mascolo, Enrica De Rosa, Minjung Cho, Yeonju Lee and Paolo Decuzzi, "Soft discoidal polymeric nanoconstructs resist macrophage uptake and enhance vascular targeting in tumors.", ACS Nano, vol. 9, no. 12, pp. 11628-11641, 2015. crossref(new window)