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Clinicopathology Profile and Bone Involvement of Multiple Myeloma Patients in Dharmais National Cancer Hospital, Indonesia
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 Title & Authors
Clinicopathology Profile and Bone Involvement of Multiple Myeloma Patients in Dharmais National Cancer Hospital, Indonesia
Sutandyo, Noorwati; Firna, Evi; Agustina, Julyanti; Prayogo, Nugroho; Widjaja, Leovinna;
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 Abstract
Background: Even though rarely found in Indonesia, the incidence of multiple myeloma (MM) is increasing every year. Bone involvement of MM is the most often a clinical disorder which leads to worsening clinical conditions and low quality of life of patients. Purpose: To determine the clinicopathology profile of bone involvement of MM patients in Indonesia. Materials and Methods: The cross-sectional study of MM conducted at Dharmais National Cancer Hospital (DNCH) by collecting data from medical records of MM patients who came to DNCH in period 2008-2012. Results: There were 39 MM patients all with age above 60 years. There were 56.4% male and 43.6% female patients. Most were diagnosed at stage III (32.4%), and 41% had obesity. The comorbid conditions were anemia (82.9%), hypoalbuminemia (60%), increased creatinine level (38.5%), increased microglobulin level (94.1%), increased LDH level (23.1%) and plasmocytes above 30% (65%), but only 4.2% patients presented with hypercalcemia. Meanwhile, bone involvement occurred in 76.9% of MM patients with 4 lesions on average and a maximum of 16 lesions. The locations of bone lesions were spine (70%), skull (70%), pelvis (33.3%), humerus (30%), and femur (30%). Conclusions: The incidence of MM in Indonesia is increasing annually with bone involvement in more than three-fourths, but interestingly without hypercalcemia.
 Keywords
Multiple myeloma;clinicopathology profile;bone involvement;Indonesia;
 Language
English
 Cited by
1.
The Immunotyping Distribution of Serum Monoclonal Paraprotein and Environmental Impact on Multiple Myeloma (MM) and Monoclonal Gammopathy of Uncertain Significance (MGUS) in Taiwan: A Medical Center-Based Experience, Asian Pacific Journal of Cancer Prevention, 2016, 17, 1, 395  crossref(new windwow)
2.
Multiple Myeloma: a Retrospective Analysis of 61 Patients from a Tertiary Care Center, Asian Pacific Journal of Cancer Prevention, 2016, 17, 4, 1833  crossref(new windwow)
3.
International Scoring System in Symptomatic Multiple Myeloma: Experience from a Tertiary Care Center, Asian Pacific Journal of Cancer Prevention, 2016, 17, 4, 2031  crossref(new windwow)
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