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Metformin Addition to Chemotherapy in Stage IV Non-Small Cell Lung Cancer: an Open Label Randomized Controlled Study
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 Title & Authors
Metformin Addition to Chemotherapy in Stage IV Non-Small Cell Lung Cancer: an Open Label Randomized Controlled Study
Sayed, Rana; Saad, Amr S; El Wakeel, Lamia; Elkholy, Engi; Badary, Osama;
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 Abstract
Purpose: To evaluate effects of metformin on clinical outcome of non-diabetic patients with stage IV NSCLC. Materials and Methods: A prospective, randomized, open-label, controlled pilot study was conducted on patients with stage IV NSCLC with an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0-2, excluding patients with diabetes and lactic acidosis. Thirty chemo-, non-diabetic patients with stage IV NSCLC were enrolled. Fifteen patients received intravenous gemcitabine/cisplatin regimen alone (arm B) while fifteen patients received the same regimen plus daily oral metformin 500mg (arm A). The effect of metformin on chemotherapy-response rates, survival, and adverse events in these patients was evaluated. Results: Objective response rate (ORR) and median overall survival (OS) in arms A and B were 46.7% versus 13.3% respectively, p
 Keywords
Metformin;lung cancer;survival;mTOR;non-small cell;
 Language
English
 Cited by
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 References
1.
Aljada A, Mousa SA (2012). Metformin and neoplasia: implications and indications. Pharmacol Ther, 133, 108-15. crossref(new window)

2.
Ashinuma H, Takiguchi Y, Kitazono S, et al (2012). Antiproliferative action of metformin in human lung cancer cell lines. Oncol Rep, 28, 8-14.

3.
Bolen S, Feldman L, Vassy J, et al (2007). Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Med, 147, 386-99. crossref(new window)

4.
Bost F, Sahra IB, Le Marchand-Brustel Y, et al (2012). Metformin and cancer therapy. Curr Opin Oncol, 24, 103-8. crossref(new window)

5.
Bradford SA, Khan A (2013). Individualizing chemotherapy using the anti-diabetic drug, metformin, as an "adjuvant": an exploratory study. J Cancer Sci Ther, 5, 6.

6.
Ceresoli GL, Cappuzzo F, Gregorc V, et al (2004). Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial. Ann Oncol, 15, 1042-7. crossref(new window)

7.
Chakraborty A, Chowdhury S, Bhattacharyya M (2011). Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Res Clin Pract, 93, 56-62. crossref(new window)

8.
Di Maio M, Bria E, Rossi A, et al (2008). Progression-free survival as primary end point in advanced non-small-cell lung cancer: does the size matter? Ann Oncol, 19, 402-3. crossref(new window)

9.
Evans JM, Donnelly LA, Emslie-Smith AM, et al (2005). Metformin and reduced risk of cancer in diabetic patients. BMJ, 330, 1304-5. crossref(new window)

10.
Forbes S, Clements J, Dawson E, et al (2006). COSMIC 2005. Br J Cancer, 94, 318-22. crossref(new window)

11.
Han D, Li SJ, Zhu YT, et al (2013). LKB1/AMPK/mTOR signaling pathway in non-small-cell lung cancer. Asian Pac J Cancer Prev, 14, 4033-9. crossref(new window)

12.
Janjetovic K, Vucicevic L, Misirkic M, et al (2011). Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. Eur J Pharmacol, 651, 41-50. crossref(new window)

13.
Jiralerspong S, Palla SL, Giordano SH, et al (2009). Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol, 27, 3297-302. crossref(new window)

14.
Klastersky J, Awada A (2012). Milestones in the use of chemotherapy for the management of non-small cell lung cancer (NSCLC). Crit Rev Oncol Hematol, 81, 49-57.

15.
Ma Y, Guo FC, Wang W, et al (2013). Kras gene mutation as a predictor of cancer cell responsiveness to metformin. Mol Med Rep, 8, 763-8.

16.
Mazzone PJ, Rai H, Beukemann M, et al (2012). The effect of metformin and thiazolidinedione use on lung cancer in diabetics. BMC Cancer, 12, 410. crossref(new window)

17.
Memmott RM, Mercado JR, Maier CR, et al (2010). Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res (Phila), 3, 1066-76. crossref(new window)

18.
Micic D, Cvijovic G, Trajkovic V, et al (2011). Metformin: its emerging role in oncology. Hormones (Athens), 10, 5-15. crossref(new window)

19.
Na, II, Choe du H, Kim CH, et al (2010). Age at diagnosis predicts outcomes in gefitinib-treated female patients with non-small-cell lung cancer. Lung Cancer, 68, 295-8. crossref(new window)

20.
Nie SP, Chen H, Zhuang MQ, et al (2014). Anti-diabetic medications do not influence risk of lung cancer in patients with diabetes mellitus: a systematic review and metaanalysis. Asian Pac J Cancer Prev, 15, 6863-9. crossref(new window)

21.
Okamoto T, Maruyama R, Shoji F, et al (2005). Long-term survivors in stage IV non-small cell lung cancer. Lung Cancer, 47, 85-91. crossref(new window)

22.
Paesmans M, Sculier JP, Libert P, et al (1995). Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1,052 patients. The European lung cancer working party. J Clin Oncol, 13, 1221-30.

23.
Tan BX, Yao WX, Ge J, et al (2011). Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes. Cancer, 117, 5103-11. crossref(new window)

24.
Tan HK, Moad AI, Tan ML (2014). The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. Asian Pac J Cancer Prev, 15, 6463-75. crossref(new window)

25.
Tang T, Lord JM, Norman RJ, et al (2012). Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiroinositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev, 5, 3053.

26.
Wang SY, Chuang CS, Muo CH, et al (2013). Metformin and the incidence of cancer in patients with diabetes: a nested case-control study. Diabetes Care, 36, 155-6.

27.
Witters LA (2001). The blooming of the French lilac. J Clin Invest, 108, 1105-7. crossref(new window)

28.
Xiao YY, Zhan P, Yuan DM, et al (2013). Chemotherapy plus Vandetanib or chemotherapy alone in advanced non-small cell lung cancer: a meta-analysis of four randomised controlled trials. Clin Oncol (R Coll Radiol), 25, 7-15. crossref(new window)

29.
Yin M, Zhou J, Gorak EJ, et al (2013). Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis. Oncol, 18, 1248-55. crossref(new window)

30.
Zhang ZJ, Li S (2014). The prognostic value of metformin for cancer patients with concurrent diabetes: a systematic review and meta-analysis. Diabetes Obes Metab, [Epub ahead of print].