Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance

Lotfi, Alireza; Mohammadi, Ghodrat; Saniee, Lale; Mousaviagdas, Mehrnoosh; Chavoshi, Hadi; Tavassoli, Atena

doi:10.7314/APJCP.2015.16.15.6749

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Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance

Journal title : Asian Pacific Journal of Cancer Prevention
Volume 16, Issue 15, 2015, pp.6749-6751
Publisher : Asian Pacific Organization for Cancer Prevetion
DOI : 10.7314/APJCP.2015.16.15.6749

Title & Authors

Serum Level of Matrix Metalloproteinase-2 and -9 in Patients with Laryngeal Squamous Cell Carcinoma and Clinical Significance
Lotfi, Alireza; Mohammadi, Ghodrat; Saniee, Lale; Mousaviagdas, Mehrnoosh; Chavoshi, Hadi; Tavassoli, Atena;

Abstract

Background: Laryngeal cancer is an important malignancy in head and neck area and squamous cell carcinoma (SCC) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different tumors and their correlation with tumor invasiveness has been documented. However, most studies have evaluated MMP-2 and MMP-9 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in patients with laryngeal SCC compared to normal subjects and assess any relation with tumor clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included. Serum levels of MMP-2 and MMP-9 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. Results: Patients with laryngeal SCC had significantly higher serum levels of MMP-2 (p

Keywords

Squamous cell carcinoma;matrix metalloproteinase 2;matrix metalloproteinase 9;

Language

English

Cited by

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