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Human Recombinant Endostatin Combined with Cisplatin Based Doublets in Treating Patients with Advanced NSCLC and Evaluation by CT Perfusion Imaging
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 Title & Authors
Human Recombinant Endostatin Combined with Cisplatin Based Doublets in Treating Patients with Advanced NSCLC and Evaluation by CT Perfusion Imaging
Zhang, Feng-Lin; Gao, Er-Yun; Shu, Rong-Bao; Wang, Hui; Zhang, Yan; Sun, Peng; Li, Min; Tang, Wei; Jiang, Bang-Qin; Chen, Shuang-Qi; Cui, Fang-Bo;
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 Abstract
Aims: To study the effectiveness of human recombinant endostatin injection (Endostar(R)) combined with cisplatin doublets in treating advanced non-small cell lung cancer (NSCLC), and to evaluate outcome by CT perfusion imaging. Methods: From April 2011 to September 2014, 76 patients with advanced NSCLC who were treated with platinum-based doublets were divided into group A (36 patients) and group B (40 patients). Endostar(R) 15mg/day was administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A, and combined with chemotherapy from the first day in Group B. Endostar(R) in the two groups was injected intravenously for 14 days. Results: Treatment effectiveness in the two groups differed with statistical significance (p<0.05). Effectiveness evaluated by CT perfusion imaging, BF, BV, MTT and PS also demonstrated significant differences (all p<0.05). Adverse reactions in the two groups did not significantly vary (p> 0.05). Conclusions: The response rate with Endostar(R) administered 4 days before chemotherapy and combined with chemotherapy from day 5 in group A was better than Endostar(R) combined with chemotherapy from the first day, and CT perfusion imaging could be a reasonable method for evaluation of patient outcomes.
 Keywords
Advanced NSCLC;platinum containing chemotherapy;CT perfusion imaging;
 Language
English
 Cited by
1.
Expression of Inhibitor of Differentiation-1 and Its Effects on Angiogenesis in Gastric Cancer, Cancer Biotherapy and Radiopharmaceuticals, 2016, 31, 7, 233  crossref(new windwow)
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