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CYP2D6 Genotype and Risk of Recurrence in Tamoxifen Treated Breast Cancer Patients
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 Title & Authors
CYP2D6 Genotype and Risk of Recurrence in Tamoxifen Treated Breast Cancer Patients
Yazdi, Mohammad Forat; Rafieian, Shiva; Gholi-Nataj, Mohsen; Sheikhha, Mohammad Hasan; Nazari, Tahereh; Neamatzadeh, Hossein;
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Background: Despite consistent pharmacogenetic effects of CYP2D6 on tamoxifen exposure, there is considerable controversy regarding the validity of CYP2D6 as a predictor of tamoxifen outcome. Understanding the current state of evidence in this area and its limitations is important for the care of patients who require endocrine therapy for breast cancer. Materials and Methods: A total of 101 patients with breast cancer who received tamoxifen therapy for at least 3 years, were genotyped for common alleles of the CYP2D6 gene by nested-PCR and restriction fragment length polymorphism PCR. Patients were classified as extensive or poor metabolizers (PM) based on CYP2D6*4 alleles in 3 different groups according to the menopause, Her2-neu status, and stage 3. Results: The mean age of the patients with the disease recurrence was and in non recurrent patients was . In this study 63.3% (n
Breast cancer;tamoxifen;recurrent;menopause;CYP2D6;
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