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Expression of Fatty Acid Synthase Negatively Correlates with PTEN and Predicts Peritoneal Dissemination of Human Gastric Cancer
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 Title & Authors
Expression of Fatty Acid Synthase Negatively Correlates with PTEN and Predicts Peritoneal Dissemination of Human Gastric Cancer
Xiang, Hong-Gang; Hao, Jun; Zhang, Wen-Jie; Lu, Wen-Jie; Dong, Ping; Liu, Ying-Bin; Chen, Lei;
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 Abstract
Background: This study aimed to examine the clinical significance of fatty acid synthase (FASN) expression in gastric cancer (GC), and investigate any prognostic role. Materials and Methods: FASN expression was assessed in gastric cancers by immunohistochemistry using 60 paraffin-embedded tissue specimens, and clinical data were collected by retrospective chart review. Moreover, FASN mRNA expression in 15 fresh resected specimens was evaluated by the reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining of PTEN was performed to assess the correlation of PTEN with FASN in gastric cancer. Results: Increased expression of FASN was noted in gastric cancers. The frequency of FASN gene amplification was also significantly higher in gastric cancer than in adjacent normal tissue. FASN expression in human gastric cancer tissues was significantly correlated with patient TNM stage and peritoneal dissemination (p<0.05). Moreover, higher FASN expression significantly correlated with shorter overall survival (p<0.05). Here, upregulation of FASN negatively correlated with PTEN expression in gastric cancer. Conclusions: These findings indicate that FASN expression is upregulated in gastric cancer, and increased FASN may be critical to th peritoneal metastasis and survival. Our results suggest that FASN upregulation and PTEN downregualtion may be involved in peritoneal dissemination for gastric cancer progression.
 Keywords
Gastric cancer;FASN;progression;PTEN;prognosis;
 Language
English
 Cited by
1.
MACC1 decreases the chemosensitivity of gastric cancer cells to oxaliplatin by regulating FASN expression, Oncology Reports, 2017, 37, 5, 2583  crossref(new windwow)
 References
1.
Ab ai FH, Wang NJ, Wang J, et al (2012). Screening and identification of peritoneal metastasis-related genes of gastric adenocarcinoma using a cDNA microarray. Genet Mol Res, 11, 1682-9. crossref(new window)

2.
Bandyopadhyay S, Pai SK, Watabe M, et al (2005). FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene, 24, 5389-95. crossref(new window)

3.
Chen J, Li T, Liu Q, et al (2014). Clinical and prognostic significance of HIF-1alpha, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis. PLoS One, 9, e91842. crossref(new window)

4.
Esslimani-Sahla M, Thezenas S, Simony-Lafontaine J, et al (2007). Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis. Int J Cancer, 120, 224-9. crossref(new window)

5.
Flavin R, Peluso S, Nguyen PL, et al (2010). Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol, 6, 551-62. crossref(new window)

6.
Furuta E, Okuda H, Kobayashi A, et al (2010). Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta, 1805, 141-52.

7.
Hou W, Fei M, Qin X, et al (2012). High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma. Exp Ther Med, 4, 999-1004.

8.
Ishimura N, Amano Y, Sanchez-Siles AA, et al (2011). Fatty acid synthase expression in Barrett’s esophagus: implications for carcinogenesis. J Clin Gastroenterol, 45, 665-72. crossref(new window)

9.
Kao YC, Lee SW, Lin LC, et al (2013). Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma. Tumour Biol, 34, 759-68. crossref(new window)

10.
Li JQ, Xue H, Zhou L, et al (2014). Mechanism of fatty acid synthase in drug tolerance related to epithelial-mesenchymal transition of breast cancer. Asian Pac J Cancer Prev, 15, 7617-23. crossref(new window)

11.
Liu ZL, Wang G, Peng AF, et al (2012). Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis. Oncol Lett, 4, 878-82.

12.
Migita T, Ruiz S, Fornari A, et al (2009). Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. J Natl Cancer Inst, 101, 519-32. crossref(new window)

13.
Molinari F, Frattini M (2013). Functions and Regulation of the PTEN Gene in Colorectal Cancer. Front Oncol, 3, 326.

14.
Rahman MT, Nakayama K, Rahman M, et al (2012). Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas. Br J Cancer, 107, 300-7. crossref(new window)

15.
Uddin S, Jehan Z, Ahmed M, et al (2011). Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis. Mol Med, 17, 635-45.

16.
Vazquez-Martin A, Colomer R, Brunet J, et al (2008). Overexpression of fatty acid synthase gene activates HER1/ HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif, 41, 59-85. crossref(new window)

17.
Vazquez-Martin A, Fernandez-Real JM, Oliveras-Ferraros C, et al (2009). Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2- positive metastatic breast cancer patients. Int J Oncol, 35, 1369-76.

18.
Wu D, Xu J, Yu G, et al (2013). Expression Staus of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma. Hepatogastroenterol, 60, 99-106.

19.
Xu WT, Yang Z, Lu NH (2014). Roles of PTEN (Phosphatase and Tensin Homolog) in gastric cancer development and progression. Asian Pac J Cancer Prev, 15, 17-24. crossref(new window)

20.
Yoshimoto M, Cunha IW, Coudry RA, et al (2007). FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Br J Cancer, 97, 678-85. crossref(new window)

21.
Zaytseva YY, Elliott VA, Rychahou P, et al (2014). Cancer cellassociated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. Carcinogenesis., 35, 1341-51. crossref(new window)

22.
Zaytseva YY, Rychahou PG, Gulhati P, et al (2012). Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res, 72, 1504-17. crossref(new window)

23.
Zeng H, Zheng R, Guo Y, et al (2014). Cancer survival in China, 2003-2005: A population-based study. Int J Cancer, 136, 1921-30.

24.
Zhu X, Qin X, Fei M, et al (2013). Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma. Exp Ther Med, 5, 57-64.