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Meningeal Hemangiopericytomas and Meningomas: a Comparative Immunohistochemical and Genetic Study
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 Title & Authors
Meningeal Hemangiopericytomas and Meningomas: a Comparative Immunohistochemical and Genetic Study
Trabelsi, Saoussen; Mama, Nadia; Chourabi, Maroua; Mastouri, Maroua Haddaji; Ladib, Mohamed; Popov, Sergey; Burford, Anna; Mokni, Moncef; Tlili, Kalthoum; Krifa, Hedi; Jones, Chris; Yacoubi, Mohamed Tahar; Saad, Ali; Brahim, Dorra H`mida-Ben;
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 Abstract
Background: The meningeal hemangiopericytoma (MHPC) is a vascular tumor arising from pericytes. Most intracranial MHPCs resemble meningiomas (MNGs) in their clinical presentation and histological features and may therefore be misdiagnosed, despite important differences in prognosis. Materials and Methods: We report 8 cases of MHPC and 5 cases of MNG collected from 2007 to 2011 from the Neuro-Surgery and Histopathology departments. All 13 samples were re reviewed by two independent pathologists and investigated by immunohistochemistry (IHC) using mesenchymal, epithelial and neuro-glial markers. Additionally, we screened all tumors for a large panel of chromosomal alterations using multiplex ligation probe amplification (MLPA). Presence of the NAB2-STAT6 fusion gene was inferred by immunohistochemical staining for STAT6. Results: Compared with MNG, MHPCs showed strong VIM (100% of cases), CD99 (62%), bcl-2 (87%), and p16 (75%) staining but only focal positivity with EMA (33%) and NSE (37%). The p21 antibody was positive in 62% of MHPC and less than 1% in all MNGs. MLPA data did not distinguish HPC from MNG, with PTEN loss and ERBB2 gain found in both. By contrast, STAT6 nuclear staining was observed in 3 MHPC cases and was absent from MNG. Conclusions: MNG and MHPC comprise a spectrum of tumors that cannot be easily differentiated based on histopathology. The presence of STAT6 nuclear positivity may however be a useful diagnostic marker.
 Keywords
Meningeal hemangiopericytoma;immunohistochemistry;NAB2-STAT6 fusion;molecular analysis;
 Language
English
 Cited by
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The impact of postoperative radiation therapy on patterns of failure and survival improvement in patients with intracranial hemangiopericytoma, Journal of Neuro-Oncology, 2016, 127, 1, 181  crossref(new windwow)
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Intracranial solitary fibrous tumors/hemangiopericytomas: first report of malignant progression, Journal of Neurosurgery, 2017, 0022-3085, 1  crossref(new windwow)
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