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Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India
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 Title & Authors
Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India
Singh, Seram Anil; Choudhury, Javed Hussain; Kapfo, Wetetsho; Kundu, Sharbadeb; Dhar, Bishal; Laskar, Shaheen; Das, Raima; Kumar, Manish; Ghosh, Sankar Kumar;
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 Abstract
Background: Tobacco and alcohol contain or may generate carcinogenic compounds related to cancers. CYP1A1 enzymes act upon these carcinogens before elimination from the body. The aim of this study was to investigate whether CYP1A1 T3801C polymorphism modulates the relationship between tobacco and alcohol-associated head and neck cancer (HNC) susceptibility among the northeast Indian population. Materials and Methods: One hundred and seventy histologically confirmed HNC cases and 230 controls were included within the study. The CYP1A1 T3801C polymorphism was determined using PCR-RFLP, and the results were confirmed by DNA sequencing. Logistic regression (LR) and multifactor dimensionality reduction (MDR) approaches were applied for statistical analysis. Results: The CYP1A1 CC genotype was significantly associated with HNC risk (P
 Keywords
Head and neck cancer;CYP1A1 T3801C polymorphism;tobacco;alcohol;northeast India;
 Language
English
 Cited by
1.
Polymorphisms of XRCC1 and XRCC2 DNA Repair Genes and Interaction with Environmental Factors Influence the Risk of Nasopharyngeal Carcinoma in Northeast India,;;

Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 6, pp.2811-2819
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