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S100A16 is a Prognostic Marker for Lung Adenocarcinomas
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 Title & Authors
S100A16 is a Prognostic Marker for Lung Adenocarcinomas
Saito, Keita; Kobayashi, Makoto; Nagashio, Ryo; Ryuge, Shinichiro; Katono, Ken; Nakashima, Hiroyasu; Tsuchiya, Benio; Jiang, Shi-Xu; Saegusa, Makoto; Satoh, Yukitoshi; Masuda, Noriyuki; Sato, Yuichi;
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Background: Many functional molecules controlling diverse cellular function are included in low-molecular weight proteins and peptides. Materials and Methods: To identify proteins controlling function in lung adenocarcinomas (AC), we performed two-dimensional gel electrophoresis employing tricine-SDS polyacrylamide in the second dimension (tricine 2-DE). This system was able to detect proteins under 1 kDa even with post-translational modifications. To confirm the utility of detected proteins as novel tumor markers for AC, we performed immunohistochemical analysis using 170 formalin-fixed and paraffin-embedded lung AC tissues. Results: Tricine 2-DE revealed that five proteins including S100A16 were overexpressed in lung AC-derived cells compared with lung squamous cell carcinoma, small cell carcinoma, and large cell neuroendocrine carcinoma-derived cells. Immunohistochemically, S100A16 showed various subcellular localization in lung cancer tissues and a membranous staining status was correlated with the T-factor (P
Lung cancer;adenocarcinoma;S100A16;tricine-2DE;tumor marker;
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