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Do Human Papilloma Viruses Play Any Role in Oral Squamous Cell Carcinoma in North Indians?
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 Title & Authors
Do Human Papilloma Viruses Play Any Role in Oral Squamous Cell Carcinoma in North Indians?
Singh, Vineeta; Husain, Nuzhat; Akhtar, Naseem; Kumar, Vijay; Tewari, Shikha; Mishra, Sridhar; Misra, Sanjeev; Khan, M.Y.;
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 Abstract
Background: Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among males in India. While tobacco and alcohol are main aetiological factors, human papilloma virus (HPV) presence has surprisingly increased in head and neck Squamous Cell Carcinoma (HNSCC) in the past two decade but its frequency in OSCCS is still uncertain. We aim to explore the frequency of HPV and its major genotypes in North Indian patients and their association with clinicopathological and histopathological features and p16 expression pattern. Materials and Methods: The study group comprised 250 histologically proven cases of OSCC. HPV was detected by real time PCR in tumor biopsy specimens and confirmed by conventional PCR with PGMY09/PGMY11 primers. Genotyping for high-risk types 16/18 was conducted by type specific PCR. p16 expression was assessed by immunohistochemsitry. Results: HPV presence was confirmed in 23/250 (9.2%) OSCC cases, of which 30.4% had HPV 16 infection, 17.4%were positive for HPV 18 and 26.1% had co-infections. HPV presence was significantly associated with male gender (p
 Keywords
Oral squamous cell carcinoma;human papilloma virus;p16;head & neck squamous cell carcinoma;
 Language
English
 Cited by
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Human papilloma virus (HPV) infection leads to the development of head and neck lesions but offers better prognosis in malignant Indian patients, Medical Microbiology and Immunology, 2017, 206, 3, 267  crossref(new windwow)
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High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil, Journal of Applied Oral Science, 2017, 25, 1, 69  crossref(new windwow)
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p16 and p53 in HPV-positive versus HPV-negative oral squamous cell carcinoma: do pathways differ?, Journal of Oral Pathology & Medicine, 2017, 46, 9, 744  crossref(new windwow)
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