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p16 Expression as a Surrogate Marker for HPV Infection in Esophageal Squamous Cell Carcinoma can Predict Response to Neo-Adjuvant Chemotherapy
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 Title & Authors
p16 Expression as a Surrogate Marker for HPV Infection in Esophageal Squamous Cell Carcinoma can Predict Response to Neo-Adjuvant Chemotherapy
Kumar, Rajeev; Ghosh, Sankar Kumar; Verma, Akalesh Kumar; Talukdar, Anuradha; Deka, Monoj Kumar; Wagh, Mira; Bahar, H.M. Iqbal; Tapkire, Ritesh; Chakraborty, Kali Pankaj; Kannan, R. Ravi;
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 Abstract
Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer in the north east of India. The present study concerned the prevalence of human papilloma virus (HPV) in the ESCC in north eastern India and its impact on response to chemotherapy. Materials and Methods: p16 expression, a surrogate marker for HPV infection was assessed in 101 pre-treatment biopsies of locally advanced ESCC, reported from a comprehensive cancer centre in north east India, using immunohistochemistry. All patients received neo-adjuvant chemotherapy. Response was assessed clinically and histopathologically with attention to p16 expression. Results: p16 was expressed in 22% of ESCC (22 out of 101) and was more prevalent in patients who were more than 45 years of age (P
 Keywords
p16;HPV;esophageal squamous cell carcinoma;response assessment;neo adjuvant chemotherapy;
 Language
English
 Cited by
1.
P16INK4a Immunostaining but Lack of Human Papilloma Virus Type 16 in Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma: a Report from West Iran,;;;;;

Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 3, pp.1093-1096 crossref(new window)
1.
Immunostaining but Lack of Human Papilloma Virus Type 16 in Cutaneous Squamous Cell Carcinoma and Basal Cell Carcinoma: a Report from West Iran, Asian Pacific Journal of Cancer Prevention, 2016, 17, 3, 1093  crossref(new windwow)
2.
HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?, Infectious Agents and Cancer, 2017, 12, 1  crossref(new windwow)
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