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Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India
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 Title & Authors
Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India
Sambyal, Vasudha; Guleria, Kamlesh; Kapahi, Ruhi; Manjari, Mridu; Sudan, Meena; Uppal, Manjit Singh; Singh, Neeti Rajan;
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Background: Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine thought to be responsible for monocyte and T-lymphocyte recruitment in acute inflammatory conditions and recruitment of macrophages in tumors. It is also implicated in cardiovascular disease, rheumatoid arthritis and chronic obstructive pulmonary disease. The aim of the present study was to investigate the correlation between MCP-1 -2518 A/G polymorphism and breast cancer risk in patients from Amritsar city of Punjab state in North-West India. Materials and Methods: We screened DNA samples of 200 sporadic breast cancer patients and 200 age and gender matched unrelated healthy individuals for MCP-1 -2518 A/G polymorphism using the PCR-RFLP method. Results: A significantly increased frequency of the GG genotype was observed in patients as compared to controls. Individuals carrying the MCP1 -2518GG genotype had a two fold risk for breast cancer (OR
Breast cancer;polymorphism;MCP-1;chemokine;risk factor;
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