JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Genetic Variation in MicroRNAs and Risk of Oral Squamous Cell Carcinoma in South Indian Population
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Genetic Variation in MicroRNAs and Risk of Oral Squamous Cell Carcinoma in South Indian Population
Sushma, PS; Jamil, Kaiser; Kumar, P Uday; Satyanarayana, U; Ramakrishna, M; Triveni, B;
  PDF(new window)
 Abstract
Background: MicroRNAs (miRNAs) are small non-coding RNA molecules, implicated in several activities like initiation, progression and prognosis of various cancers. Single nucleotide polymorphisms (SNPs) in miRNA genes can lead to alteration in mRNA expression, resulting in diverse functional consequences. The aim of our study was to investigate the association of miR-149C>T and miR-196a2C>T SNPs with susceptibility to development of oral squamous cell carcinoma (OSCC) in South Indian subjects. Materials and Methods: 100 OSCC patients and 102 healthy controls from the general population were recruited for the study. Genetic analysis was performed by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) as per a standard protocol. Results: The genotype frequencies in miR-196a2 polymorphism, of TT, CT and CC in the OSCC patients were 69%,10% and 22% respectively while for control group it was 80%, 15% and 5% respectively. The CC genotype of miR196a2 polymorphism was significantly associated with oral squamous cell carcinoma. The genotype frequencies in miR-149 polymorphisms of CC, CT and TT in the oral squamous cell carcinoma (OSCC) patients were 72%, 22% and 6% respectively and for control group 88%, 12% and 0% respectively. CT and TT genotypes of miR149 polymorphism were found to be significantly associated with OSCC (p
 Keywords
miRNA;polymorphisms;oral squamous cell carcinoma;PCR-RFLP;genotypes;South India;
 Language
English
 Cited by
1.
The Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies, Open Journal of Internal Medicine, 2016, 06, 04, 112  crossref(new windwow)
 References
1.
Ahn DH, Rah H, Choi YK, et al (2013). Association of the miR- 146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population. Mol Carcinog, 52, 39-51.

2.
Akkiz H, Bayram S, Bekar A, et al (2011). A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study. J Viral Hepat, 18, 399-407. crossref(new window)

3.
Ambros V (2004). The functions of animal micro RNAs. Nature, 431, 350-5. crossref(new window)

4.
Aqeilan RI, Calin GA, Croce CM (2010). miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ, 17, 215-20. crossref(new window)

5.
Bartel DP (2004). MicroRNAs: Genomics, Review Biogenesis, Mechanism, and Function. Cell, 116, 281-97. crossref(new window)

6.
Chu H, Wang M, Shi D, et al (2011). Hsa-miR-196a2 Rs11614913 polymorphism contributes to cancer susceptibility: evidence from 15 case-control studies. PLoS One, 6, 18108. crossref(new window)

7.
Chen H, Sun LY, Chen LL, et al (2012). A variant in microRNA- 196a2 is not associated with susceptibility to and progression of colorectal cancer in Chinese. Intern Med J, 42, 115-119. crossref(new window)

8.
Dou T, Wu Q, Chen X, et al (2010). A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population. J Cancer Res Clin Oncol, 136, 1853-9. crossref(new window)

9.
Elango JK, Gangadharan P, Sumithra S, et al (2006). Trends of head and neck cancers in urban and rural India. Asian Pac J Cancer Prev, 7, 108-11.

10.
George GP, Gangwar R, Mandal RK, et al (2011). Genetic variation in microRNA genes and prostate cancer risk in North Indian population. Mol Biol Rep, 38, 1609-15. crossref(new window)

11.
Gregory RI, Shiekhattar R (2005). MicroRNA biogenesis and cancer. Cancer Res, 65, 3509-3512. crossref(new window)

12.
Huang GL, Lu Y, Pu XX, et al (2013). Association study between miR149 gene polymorphism and nasopharyngeal carcinoma. Biomed Rep, 1, 599-603. crossref(new window)

13.
Hu Z, Chen J, Tian T, et al (2008). Genetic variants of miRNA sequences and non-small cell lung cancer survival. J Clin Invest, 118, 2600-8.

14.
Jazdzewski K, Murray EL, Franssila K, et al (2008). Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci U S A, 105, 7269-74. crossref(new window)

15.
Kwak PB, Iwasaki S, Tomari Y (2010). The microRNA pathway and cancer. Cancer Sci, 101, 2309-15. crossref(new window)

16.
Lewis, Benjamin P, Christopher B, et al (2005). Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets, Cell, 120, 15-20. crossref(new window)

17.
Lin T, Ding Z, Li N, et al (2011). 2-Tellurium-bridged $\beta$-cyclodextrin, a thioredoxinreductase inhibitor, sensitizes human breast cancer cells to TRAIL-induced apoptosis through DR5 induction and NF-kB suppression. Carcinogenesis, 32, 154-167. crossref(new window)

18.
Liu Z, Li G, Wei S, et al (2010). Genetic variants in selected pre-mircroRNA genes and risk of squamous cell carcinoma of the head and neck. Cancer, 116, 4753-60. crossref(new window)

19.
Lovat, Francesca, Nicola Valeri, Carlo M, Croce (2011). MicroRNAs in the pathogenesis of cancer. Seminars Oncolo, 38, 6.

20.
Okubo M, Tahara T, Shibata T, et al (2010). Association between common genetic variants in pre-microRNAs and gastric cancer risk in japanese population. Helicobacter, 15, 524-531. crossref(new window)

21.
Peng S, Kuang Z, Sheng C, et al (2010). Association of microRNA-196a-2 gene polymorphism with gastric cancer risk in a Chinese population. Dig Dis Sci, 55, 2288-93. crossref(new window)

22.
Rai R, Kulkarni V, Saranath D (2004). Genome wide instability scanning in chewing-tobacco associated oral cancer using inter simple sequence repeat PCR. Oral Oncol, 40, 1033-9. crossref(new window)

23.
Ryan BM, Robles AI, Harris CC (2010). Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer, 10, 389-402. crossref(new window)

24.
Salzman DW, Weidhaas JB (2013). SNPing cancer in the bud: MicroRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer. Pharmacol Ther, 137, 55-63. crossref(new window)

25.
Sassen S, Miska EA, Caldas C (2008). MicroRNA: implications for cancer. Virchows Arch, 452, 1-10.

26.
Sheng Peng, Zhong shen Kuang, Chenyi Sheng, et al (2010). Association of miRNA 196a - 2 gene polymorphism with gastric cancer risk in a Chinese population. Dig Dis Sci, 55, 2288- 93. crossref(new window)

27.
Shen J1, Ambrosone CB, DiCioccio RA, etal (2008). A functional polymorphism in the miR146a gene and age of familial breast/ovarian cancer diagnosis. Carcinogenesis, 29, 1963-1966. crossref(new window)

28.
Tu HF, Liu CJ, Chang CL, et al. (2012) The Association between Genetic Polymorphism and the Processing Efficiency of miR-149Affects the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma. PLoS ONE, 7, 51606. crossref(new window)

29.
Wang K, Guo H, Hu H, Xiong G, et al (2010). A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han. Biomarkers, 15, 614-8. crossref(new window)

30.
Wang N, Li Y, Zhou RM, et al (2014). Hsa-miR-196a2 functional SNP is associated with the risk of ESCC in individuals under 60 years old. Biomarkers, 19, 43-48. crossref(new window)

31.
Xu T, Zhu Y, Wei QK, et al (2008). A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis, 29, 2126-31. crossref(new window)

32.
Xu Y, Liu L, Liu J, et al (2011). A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer, 128, 412-417. crossref(new window)

33.
Yang H, Dinney CP, Ye Y, et al (2008). Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res, 68, 2530-7. crossref(new window)

34.
Yoon KA, Yoon H, Park S, et al (2012). The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer. J Thorac Cardio Vas cSurg, 144, 794-807. crossref(new window)