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Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases
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 Title & Authors
Relation of BAALC and ERG Gene Expression with Overall Survival in Acute Myeloid Leukemia Cases
Rashed, Reham A; Kadry, Dalia Y; Taweel, Maha EL; Abd El Wahab, Nahed; Abd El Hameed, Thoreya;
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 Abstract
Background: The objectives of this study were to evaluate the expression of brain and acute leukemia, cytoplasmic (BAALC) gene and erythroblast transformation-specific related gene (ERG) in de novo cases of acute myeloid leukemia (AML) and identify roles in disease progression and outcome. Materials and Methods: This study included 50 newly diagnosed AML patients, along with 10 apparently healthy normal controls. BAALC and ERG expression was detected in the bone marrow of both patients and controls using real-time RT-PCR. Results: BAALC and ERG expression was detected in 52% of cases but not in any controls. There was a statistically significant correlation between BAALC and ERG gene expression and age (p-value
 Keywords
BAALC;ERG;AML;RT-PCR;
 Language
English
 Cited by
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