JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Acute Promyelocytic Leukemia: a Single Center Study from Southern Pakistan
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Acute Promyelocytic Leukemia: a Single Center Study from Southern Pakistan
Sultan, Sadia; Irfan, Syed Mohammed; Ashar, Sana;
  PDF(new window)
 Abstract
Background: Acute promyelocytic leukemia (APL) is a distinctive clinical, biological and molecular subtype of acute myeloid leukemia. However, data from Pakistan are scarce. Therefore we reviewed the demographic and clinical profile along with risk stratification of APL patients at our center. Materials and Methods: In this descriptive cross sectional study, 26 patients with acute promyelocytic leukemia were enrolled from January 2011 to June 2015. Data were analyzed with SPSS version 22. Results: The mean age was with a median of 32 years. The female to male ratio was 2:1.2. The majority of our patients had hypergranular variant (65.4%) rather than the microgranular type. The major complaints were bleeding (80.7%), fever (76.9%), generalized weakness (30.7%) and dyspnea (15.38%). Physical examination revealed petechial rashes as a predominant finding detected in 61.5% followed by pallor in 30.8%. The mean hemoglobin was with the mean MCV of . The mean total leukocyte count of ; ANC of and mean platelets count were . According to risk stratification, 15.3% were in high, 65.4% in intermediate and 19.2% in low risk groups. Conclusions: Clinico-epidemiological features of APL in Pakistani patients appear comparable to published data. Haemorrhagic diathesis is the commonest presentation. Risk stratification revealed predominance of intermediate risk disease.
 Keywords
Acute promyelocytic leukemia;clinico-epidemiological;risk stratification;Pakistan;
 Language
English
 Cited by
 References
1.
Ambayya A, BBiomed, Zainina S, et al (2014). Antigen expression pattern of acute promyelocytic leukemia cases in Malaysia. Med J Malaysia, 69, 64-9.

2.
Avvisati G, Lo Coco F, Diverio D, et al (1996). AIDA (alltrans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) pilot study. Blood, 88, 1390-8.

3.
Bajpai J, Sharma A, Kumar L, et al (2011). Acute promyelocytic leukemia: An experience from a tertiary care centre in north India. Indian J Cancer, 48, 316-22. crossref(new window)

4.
Breen KA, Grimwade D, Hunt BJ (2012). The pathogenesis and management of the coagulopathy of acute promyelocytic leukaemia. Br J Haematol, 156, 24-36. crossref(new window)

5.
Chen P, Huang HF, Lu R, Wu Y, Chen YZ (2012). Prognostic significance of CD44v6/v7 in acute promyelocytic leukemia. Asian Pac J Cancer Prev, 13, 3791-4. crossref(new window)

6.
Chang H, Kuo MC, Shih LY, et al (2013). Acute promyelocytic leukemia-associated thrombosis. Acta Haematol, 130, 1-6. crossref(new window)

7.
Devita VT, Hellman S, Rosenberg SA (2008). Acute leukemias. DeVita VT, Rosenberg SA, Lawrence TS, eds. DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 8th ed. Philadelphia, Pa: Lippincott, Williams and Wilkins, 2, 2240-1.

8.
Dutta P, Sazawal S, Kumar R, Saxena R (2008). Does acute promyelocytic leukemia in Indian patients have biology different from the West? Indian J Pathol Microbiol, 51, 437-9. crossref(new window)

9.
Duffield AS, Aoki J, Levis M, et al (2012). Clinical and pathologic features of secondary acute promyelocytic leukemia. Am J Clin Pathol, 137, 395-402. crossref(new window)

10.
Esteve J, Escoda L, Marti n G, et al (2007). Spanish Cooperative Group PETHEMA. outcome of patients with acute promyelocytic leukemia failing to front-line treatment with all-trans retinoic acid and anthracycline-based chemotherapy (PETHEMA protocols LPA96 and LPA99): benefit of an early intervention. Leukemia, 21, 446-52. crossref(new window)

11.
Hillestad LK (1957). Acute promyelocytic leukemia. Acta Med Scand, 159, 189-94.

12.
Imani-Saber Z and Ghafouri-Fard S (2014). Promyelocytic leukemia gene functions and roles in tumorigenesis. Asian Pac J Cancer Prev, 15, 8021-8.

13.
Karim F, Shaikh U, Adil SN, Khurshid M (2014). Clinical characteristics, outcome and early induction deaths in patients with acute promyelocytic leukaemia: a five-year experience at a tertiary care centre. Singapore Med J, 55, 443-7. crossref(new window)

14.
Khorshid O, Diaa A, Moaty MA, et al (2011). Clinical features and treatment outcome of acute promyelocytic leukemia patients treated at cairo national cancer institute in egypt. Mediterr J Hematol Infect Dis, 3, 2011060. crossref(new window)

15.
Liang JY, Wu DP, Liu YJ, et al (2008). The clinical and laboratory features of acute promyelocytic leukemia: an analysis of 513 cases. Zhonghua Nei Ke Za Zhi, 47, 389-92.

16.
Lou Y, Ma Y, Suo S, et al (2015). Prognostic factors of patients with newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide-based frontline therapy. Leuk Res, 39, 938-44 crossref(new window)

17.
Mandegary A, Rostami S, Alimoghaddam K, Ghavamzadeh A, Ghahremani MH (2011). Gluthatione-S-transferase T1- null genotype predisposes adults to acute promyelocytic leukemia; a case-control study. Asian Pac J Cancer Prev, 12, 1279-82.

18.
Montesinos P, Rayon C, Vellenga E, PETHEMA; HOVON Groups, et al (2011). Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens. Blood, 117, 1799-805. crossref(new window)

19.
Mitrovic M, Suvajdzic N, Elezovic I, et al (2015). Thrombotic events in acute promyelocytic leukemia. Thromb Res, 135, 588-93. crossref(new window)

20.
Park JH, Qiao B, Panageas KS, et al (2011). Early death rate in acute promyelocytic leukemia remains high despite all-trans retinoic acid. Blood, 118, 1248-54. crossref(new window)

21.
Sanz MA, Lo Coco F, Marti n G, et al (2000). Definition of relapse risk and role of nonanthracycline drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups. Blood, 96, 1247-53.

22.
Ziaei JE (2004). High frequency of acute promyelocytic leukemia in northwest Iran. Asian Pac J Cancer Prev, 5, 188-9.