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Helicobacter pylori Infection and Gastric Mucosal Atrophy in Two Ethnic Groups in Nepal
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 Title & Authors
Helicobacter pylori Infection and Gastric Mucosal Atrophy in Two Ethnic Groups in Nepal
Miftahussurur, Muhammad; Sharma, Rabi Prakash; Shrestha, Pradeep Krishna; Maharjan, Ramesh Kumar; Shiota, Seiji; Uchida, Tomohisa; Sato, Hiroki; Yamaoka, Yoshio;
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Serum anti-Helicobacter pylori antibodies and pepsinogens (PGs) have been used as gastric cancer screening and gastric mucosal status markers. Nepal is a low risk country for gastric cancer. However, the mountainous populace in the northern region culturally linked to Tibet as well as Bhutan, a neighboring country, have a high risk of GC. We collected gastric biopsy specimens and sera from 146 dyspeptic patients living in Kathmandu, Nepal. We also examined the sera of 80 volunteers living in the mountainous regions of the Himalayas. The optimal cut-off was calculated for serum biomarkers against the histology. Kathmandu patients (43.8%) were serologically positive for H. pylori infection, which was significantly lower than that for the mountainous (61.3%, P
Helicobacter pylori;pepsinogens;gastric cancer;Nepal;
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