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β-Adrenergic Receptors : New Target in Breast Cancer
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 Title & Authors
β-Adrenergic Receptors : New Target in Breast Cancer
Wang, Ting; Li, Yu; Lu, Hai-Ling; Meng, Qing-Wei; Cai, Li; Chen, Xue-Song;
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Background: Preclinical studies have demonstrated that -adrenergic receptor antagonists could improve the prognosis of breast cancer. However, the conclusions of clinical and pharmacoepidemiological studies have been inconsistent. This review was conducted to re-assess the relationship between beta-adrenoceptor blockers and breast cancer prognosis. Materials and Methods: The literature was searched from PubMed, EMBASE and Web of Nature (Thompson Reuters) databases through using key terms, such as breast cancer and beta-adrenoceptor blockers. Results: Ten publications met the inclusion criteria. Six suggested that receiving beta-adrenoceptor blockers reduced the risk of breast cancer-specific mortality, and three of them had statistical significance (hazard ratio (HR)
Beta-adrenoceptor blockers;breast cancer;prognosis;systematic review;
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Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 6, pp.2953-2957
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