JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Outcome and Cost Effectiveness of Ultrasonographically Guided Surgical Clip Placement for Tumor Localization in Patients undergoing Neo-adjuvant Chemotherapy for Breast Cancer
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Outcome and Cost Effectiveness of Ultrasonographically Guided Surgical Clip Placement for Tumor Localization in Patients undergoing Neo-adjuvant Chemotherapy for Breast Cancer
Masroor, Imrana; Zeeshan, Sana; Afzal, Shaista; Sufian, Saira Naz; Ali, Madeeha; Khan, Shaista; Ahmad, Khabir;
  PDF(new window)
 Abstract
Background: To determine the outcome and cost saving by placing ultrasound guided surgical clips for tumor localization in patients undergoing neo-adjuvant chemotherapy for breast cancer. Materials and Methods: This retrospective cross sectional analytical study was conducted at the Department of Diagnostic Radiology, Aga Khan University Hospital, Karachi, Pakistan from January to December 2014. A sample of 25 women fulfilling our selection criteria was taken. All patients came to our department for ultrasound guided core biopsy of suspicious breast lesions and clip placement in the index lesion prior to neo-adjuvant chemotherapy. All the selected patients had biopsy proven breast cancer. Results: The mean age was . There were no complications seen after clip placement in terms of clip migration or hemorrhage. The cost of commercially available markers was approximately PKR 9,000 (US$ 90) and that of the surgical clip was PKR 900 (US$ 9). The cost of surgical clips in 25 patients was PKR 22,500 (US$ 225), when compared to the commercially available markers which may have incurred a cost of PKR 225,000 (US$ 2,250). The total cost saving for 25 patients was PKR 202,500 (US$ 2, 025), making it PKR 8100 (US$ 81) per patient. Conclusions: The results of our study show that ultrasound guided surgical clip placement in index lesions prior to neo-adjuvant therapy is a safe and cost effective method to identify tumor bed and response to treatment for further management.
 Keywords
Breast cancer;neo adjuvant chemotherapy;biopsy;surgical clip marker;
 Language
English
 Cited by
 References
1.
Abdel-Razeq H, Marei L (2011). Current neoadjuvant treatment options for HER2-positive breast cancer. Biologics, 5, 87-94

2.
Baron LF, Baron PL, Ackerman SJ, Durden DD, Pop TL Jr (2000). Sonographically guided clip placement facilitates localization of breast cancer after neoadjuvant chemotherapy. Am J Roentgenol, 174, 539-40 crossref(new window)

3.
Dash N, Chafin S, Johnson RR, Contractor FM (1999). Usefulness of tissue marker clips in patients undergoing neoadjuvant chemotherapy for breast cancer. Am J Roentgenol, 173, 911-7 crossref(new window)

4.
Ediken BS, Fornage BD, Bedi DG, et al (1999). US-guided implantation of metallic markers for permanent localization of the tumor bed in patients with breast cancer who undergo preoperative chemotherapy. Radiology, 213, 895-900 crossref(new window)

5.
Genson CC, Blane CE, et al (2007). Effects on breast MRI of artifacts caused by metallic tissue marker clips. Am J Roentgenol, 188, 372-6 crossref(new window)

6.
Kaufmann M, von Minckwitz G, Bear HD, et al (2007). Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: new perspectives 2006. Ann Oncol, 18, 1927-34. crossref(new window)

7.
Kaufmann M, von Minckwitz G, Mamounas EP, et al (2012). Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer. Ann Surg Oncol, 19, 1508-16 crossref(new window)

8.
Lee SY, Kook SH, Kwag HJ (2005). The results and usefulness of marker clip placement after ultrasound-guided mammotome excision of breast lesion. J Korean Radiol Soc, 52, 207-13 crossref(new window)

9.
Lobbes MB, Prevos R, Smidt M, et al (2013). The role of magnetic resonance imaging in assessing residual disease and pathologic complete response in breast cancer pa¬tients receiving neoadjuvant chemotherapy: a systematic review. Insights Imaging, 4, 163-75 crossref(new window)

10.
Margolin FR, Jacobs RP, Denny SR, Schrumpf JD (2003). Clip placement after sonographically guided percutaneous breast biopsy. Breast J, 9, 226-30 crossref(new window)

11.
Oh JL, Nguyen G, Whitman GJ, et al (2007). Placement of radiopaque clips for tumor localization in patients un¬dergoing neoadjuvant chemotherapy and breast conservation therapy. Cancer, 110, 2420-7 crossref(new window)

12.
Uematsu T (2007). Commercially available titanium clip placement following a sonographically guided core needle biopsy of breast. Breast J, 13, 624-6 crossref(new window)

13.
Youn I, Choi SH, Kook SH, Choi YJ, et al (2015). Ultrasonographyguided surgical clip placement for tumor localization in patients undergoing neoadjuvant chemotherapy for breast cancer. J Breast Cancer, 18, 44-49. crossref(new window)