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Epidemiological Characteristics of Gallbladder Cancer in Jeju Island: A Single-Center, Clinically Based, Age-Sex-Matched, Case-Control Study
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 Title & Authors
Epidemiological Characteristics of Gallbladder Cancer in Jeju Island: A Single-Center, Clinically Based, Age-Sex-Matched, Case-Control Study
Cha, Byung Hyo;
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 Abstract
Background: Gallbladder cancer (GBC) is a rare but highly invasive malignancy characterized by poor survival. In a national cancer survey, the age-standardized incidence rate of GBC was highest in Jeju Island among the 15 provinces in South Korea. The aim of this descriptive epidemiological study was to suggest the modifiable risk factors for this rare malignant disease in Jeju Island by performing an age-sex-matched case-control study. Materials and Methods: The case group included patients diagnosed with GBC at the Department of Internal Medicine of Cheju Halla General Hospital, Jeju, South Korea, within the 5-year study period. The control group consisted of age-sex-matched subjects selected from among the participants of the health promotion center at the same institute and in the same period. We compared 78 case-control pairs in terms of clinical variables such as histories of hypertension, diabetes, vascular occlusive disorders, alcohol and smoking consumption, obesity, and combined polypoid lesions of the gallbladder (PLG) or gallstone diseases (GSDs). Results: Among the relevant risk factors, alcohol consumption, parity , PLG, and GSDs were significant risk factors in the univariate analysis. PLG (p < 0.01; OR, 51.1; 95% confidence interval [CI], 2.98-875.3) and GSD (p < 0.01; OR, 54.9; 95% CI, 3.00-1001.8) were associated risk factors of GBC in the multivariate analysis with the conditional logistic regression model. However, we failed to find any correlation between obesity and GBC. We also found a negative correlation between alcohol consumption history and GBC in the multivariate analysis (p < 0.01; OR, 0.06; 95% CI, 0.01-0.31). Conclusions: These results suggest that combined PLG and GSDs are strongly associated with the GBC in Jeju Island and mild to moderate alcohol consumption may negatively correlate with GBC risk.
 Keywords
Gallbladder cancer;risk factor;Gallstone disease;alcohol consumption;
 Language
English
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 References
1.
Ahrens W, Timmer A, Vyberg M, et al (2007). Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study. Eur J Gastroenterol Hepatol, 19, 623-30. crossref(new window)

2.
Alvi AR, Siddiqui NA, Zafar H (2011). Risk factors of gallbladder cancer in Karachi-a case-control study. World J Surg Oncol, 9, 164. crossref(new window)

3.
Bae J-M (2012). Regional difference in the occurrence of cancers on biliary system in Korea: a descriptive epidemiological study. Korean Public Health Res, 38, 49-55.

4.
Bagnardi V, Rota M, Botteri E, et al (2015). Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer, 112, 580-93. crossref(new window)

5.
Calle, EE, Rodriguez C, Walker-Thurmond K (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. New Engl J Med, 348, 1625-38. crossref(new window)

6.
Cha BH, Bae JM (2014). Comparison of clinical outcomes of incidental gallbladder cancers: a single-center crosssectional study. Asian Pac J Cancer Prev, 15, 1281-3. crossref(new window)

7.
Chow WH, McLaughlin JK, Menck HR, et al (1994). Risk factors for extrahepatic bile duct cancers: Los Angeles County, California (USA). Cancer Causes Control, 5, 267-72. crossref(new window)

8.
Li Y, Yang H, Cao J (2011). Association between alcohol consumption and cancers in the Chinese population: a systematic review and meta-analysis. PLoS One, 6, 18776. crossref(new window)

9.
Liu B, Balkwill A, Roddam A, et al (2009). Separate and joint effects of alcohol and smoking on the risks of cirrhosis and gallbladder disease in middle-aged women. Am J Epidemiol, 169, 153-60.

10.
McNemar Q (1947). Note on the sampling error of the difference between correlated proportions or percentages. Psychometrika, 12, 153-7. crossref(new window)

11.
Ozasa, K (2007). Alcohol use and mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC). Asian Pac J Cancer Prev, 8, 81-8.

12.
Randi G, Franceschi S, La Vecchia C (2006). Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer, 118, 1591-602. crossref(new window)

13.
Strom BL, Soloway RD, Rios-Dalenz JL, et al (1995). Risk factors for gallbladder cancer: an international collaborative case-control study. Cancer, 76, 1747-56. crossref(new window)

14.
WHO Expert Consultation (2004). Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet, 363, 157-63. crossref(new window)

15.
Yagyu K, Kikuchi S, Obata Y (2008). Cigarette smoking, alcohol drinking and the risk of gallbladder cancer death: a prospective cohort study in Japan. Int J Cancer, 122, 924-9. crossref(new window)

16.
Zatonski WA, Lowenfels AB, Boyle P, et al (1997). Epidemiologic aspects of gallbladder cancer: a case-control study of the SEARCH Program of the International Agency for Research on Cancer. J Natl Cancer Inst, 89, 1132-8. crossref(new window)