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DPPA2 Protein Expression is Associated with Gastric Cancer Metastasis
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 Title & Authors
DPPA2 Protein Expression is Associated with Gastric Cancer Metastasis
Shabestarian, Hoda; Ghodsi, Mohammad; Mallak, Afsaneh Javdani; Jafarian, Amir Hossein; Montazer, Mehdi; Forghanifard, Mohammad Mahdi;
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Gastric cancer (GC) as the fourth most common cause of malignancies shows high rate of morbidity appropriating the second leading cause of cancer-related death worldwide. Developmental pluripotency associated-2 (DPPA2), cancer-testis antigen (CT100), is commonly expressed only in the human germ line and pluripotent embryonic cells but it is also present in a significant subset of malignant tumors. To investigate whether or not DPPA2 expression is recalled in GC, our aim in this study was to elucidate DPPA2 protein expression in gastric cancer. Fifty five GC tumor and their related margin normal tissues were recruited to evaluate DPPA2 protein expression and its probable associations with different clinicopathological features of the patients. DPPA2 was overexpressed in GC cases compared with normal tissues (P < .005). While DPPA2 expression was detected in all GC samples, its high expression was found in 23 of 55 tumor tissues (41.8%). Interestingly, 50 of 55 normal samples (90.9%) were negative for DPPA2 protein expression and remained 5 samples showed very low expression of DPPA2. DPPA2 protein expression in GC was significantly correlated with lymph node metastasis (p
Gastric cancer;DPPA2;immunohistochemistry;metastasis;
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Akhavan-Niaki H, Samadani AA (2014). Molecular insight in gastric cancer induction: an overview of cancer stemness genes. Cell Biochem Biophys, 68, 463-73. crossref(new window)

Amini S, Fathi F, Mobalegi J, et al (2014). The expressions of stem cell markers: Oct4, NANOG, SOX2, nucleostemin, Bmi, Zfx, Tcl1, Tbx3, Dppa4, and Esrrb in bladder, colon, and prostate cancer, and certain cancer cell lines. Anat Cell Biol, 47, 1-11. crossref(new window)

Aravind L, Koonin EV (2000). SAP-a putative DNA-binding motif involved in chromosomal organization. Trends Biochem Sci, 25, 112-4. crossref(new window)

Cho J, Lim J, Cheong J, et al (2011). Gene expression signaturebased prognostic risk score in gastric cancer. Clin Cancer Res, 17, 1850-7. crossref(new window)

Du J, Chen T, Zou X, et al (2010). Dppa2 knockdown-induced differentiation and repressed proliferation of mouse embryonic stem cells. J Biochem, 147, 265-71. crossref(new window)

Ferlay J, Parkin DM, Steliarova-Foucher E (2010). Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer, 46, 765-81. crossref(new window)

Forghanifard MM, Ardalan Khales S, Javdani-Mallak A, et al (2014). Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma. Med Oncol, 31, 922. crossref(new window)

Gagliardi A, Mullin NP, Ying Tan Z, et al (2013). A direct physical interaction between NANOG and SOX2 regulates embryonic stem cell self-renewal. EMBO J, 32, 2231-47. crossref(new window)

Ghodsi M, Jafarian AH, Montazer M, et al (2015). Diagnostic clinical relevance of developmental pluripotency-associated 2 (DPPA2) in colorectal cancer. Int J Surg.

Huang ZJ, Wang R, Luo WY, et al (2012). Expression of OCT4 in gastric cancer cell lines and its significance. Sichuan Da Xue Xue Bao Yi Xue Ban, 43, 812-5.

Hudler P (2012). Genetic aspects of gastric cancer instability. Scientific World J, 2012, 761909.

Hutz K, Mejias-Luque R, Farsakova K, et al (2014). The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells. Carcinogenesis, 35, 942-50. crossref(new window)

Ivanova N, Dobrin R, Lu R, et al (2006). Dissecting self-renewal in stem cells with RNA interference. Nature, 442, 533-8. crossref(new window)

Ji W, Jiang Z (2013). Effect of shRNA-mediated inhibition of NANOG gene expression on the behavior of human gastric cancer cells. Oncol Lett, 6, 367-74. crossref(new window)

John T, Caballero OL, Svobodova SJ, et al (2008). ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancertestis antigens in non-small cell lung cancer. Clin Cancer Res, 14, 3291-8. crossref(new window)

Kong D, Su G, Zha L, et al (2014). Coexpression of HMGA2 and Oct4 predicts an unfavorable prognosis in human gastric cancer. Med Oncol, 31, 130. crossref(new window)

Maldonado-Saldivia J, van den Bergen J, Krouskos M, et al (2007). Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line. Stem Cells, 25, 19-28. crossref(new window)

Matsuoka J, Yashiro M, Sakurai K, et al (2012). Role of the stemness factors SOX2, oct3/4, and NANOG in gastric carcinoma. J Surg Res, 174, 130-5. crossref(new window)

Mayer W, Niveleau A, Walter J, et al (2000). Demethylation of the zygotic paternal genome. Nature, 403, 501-2.

Monk M, Boubelik M, Lehnert S (1987). Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development, 99, 371-82.

Monk M, Hitchins M, Hawes S (2008). Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development. Mol Hum Reprod, 14, 347-55. crossref(new window)

Monk M, Holding C (2001). Human embryonic genes reexpressed in cancer cells. Oncogene, 20, 8085-91. crossref(new window)

Mottaghi-Dastjerdi N, Soltany-Rezaee-Rad M, Sepehrizadeh Z, et al (2014). Genome expression analysis by suppression subtractive hybridization identified overexpression of Humanin, a target gene in gastric cancer chemoresistance. Daru, 22, 14. crossref(new window)

Raeisossadati R, Abbaszadegan MR, Moghbeli M, et al (2014). Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis. Tumour Biol.

Reik W, Dean W, Walter J (2001). Epigenetic reprogramming in mammalian development. Science, 293, 1089-93. crossref(new window)

Takeno A, Takemasa I, Seno S, et al (2010). Gene expression profile prospectively predicts peritoneal relapse after curative surgery of gastric cancer. Ann Surg Oncol, 17, 1033-42. crossref(new window)

Tan IB, Ng I, Tai WM, et al (2012). Understanding the genetic basis of gastric cancer: recent advances. Expert Rev Gastroenterol Hepatol, 6, 335-41. crossref(new window)

Tchabo NE, Mhawech-Fauceglia P, Caballero OL, et al (2009). Expression and serum immunoreactivity of developmentally restricted differentiation antigens in epithelial ovarian cancer. Cancer Immun, 9, 6.

Tung PY, Varlakhanova NV, Knoepfler PS (2013). Identification of DPPA4 and DPPA2 as a novel family of pluripotencyrelated oncogenes. Stem Cells, 31, 2330-42. crossref(new window)

Wu JY, Cheng CC, Wang JY, et al (2014). Discovery of tumor markers for gastric cancer by proteomics. PLoS One, 9, 84158. crossref(new window)

Yang J, Chai L, Fowles TC, et al (2008). Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proc Natl Acad Sci U S A, 105, 19756-61. crossref(new window)

Zabaleta J (2012). Multifactorial etiology of gastric cancer. Methods Mol Biol, 863, 411-35. crossref(new window)