Advanced SearchSearch Tips
Treating Adults with Hodgkin Lymphoma in the Developing World: a Hospital-Based Cohort Study from Armenia
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Treating Adults with Hodgkin Lymphoma in the Developing World: a Hospital-Based Cohort Study from Armenia
Avagyan, Armen; Danielyan, Samvel; Voskanyan, Astghik; Sargsyan, Lilit; Hakobyan, Lusine; Zohrabyan, Davit; Safaryan, Liana; Harutyunyan, Lilit; Bardakchyan, Samvel; Iskanyan, Samvel; Arakelyan, Samvel; Tamamyan, Gevorg;
  PDF(new window)
Background: With advances in diagnostics and treatment approaches, patients with Hodgkin`s lymphoma (HL) in developed countries can nowadays expect to have excellent outcomes. However, information about the characteristics and outcomes in the developing world is very scarce, and this is important given the fact that there are several reports about differences of disease characteristics depending on geographic location and the development level of the country. Materials and Methods: In this retrospective study we assessed the features of 36 adult ( years old) patients with HL and their diagnosis and treatment and outcomes in the Clinic of Chemotherapy of Muratsan University Hospital of Yerevan State Medical University, Armenia, between 2008-2014. Results: All patients had classic HL and among them 19 (53%) had nodular sclerosis subtype, 8 (22%) mixed cellularity and 9 (25%) lymphocyte-rich. 16 (44.5%) patients were at stage II, 13 (36%) stage III and 7 (19.5%) stage IV. Median follow-up time was 24.5 months (range 1-71 months) and during the whole follow-up period only two relapses (early) were documented and there were no deaths. Twenty-three (64%) patients received a BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) regimen, and 13 (36%) ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) regimen. A total of 25 (69.5%) patients received radiation in addition to chemotherapy. Conclusions: Although the number of patients involved in the study is small and the median follow-up time was just two years, this retrospective study shows that treatment of HL can be successfully organized in a resource-limited setting.
Hodgkin`s lymphoma;developing country;Armenia;ABVD;BEACOPP;
 Cited by
Andjelic B, Antic D, Jakovic L, et al (2014). A single institution experience on 314 newly diagnosed advanced hodgkin lymphoma patients: the role of ABVD in daily practice. Eur J Haematol, 93, 392-99. crossref(new window)

Baharvand M, Mortazavi H (2014). Characteristics of Hodgkin lymphoma in a defined group of iranian pediatric patients. Asian Pac J of Cancer Prev, 15, 5167-69. crossref(new window)

Bosetti C, Levi F, Ferlay J, et al (2009). The recent decline in mortality from hodgkin lymphomas in central and eastern europe. Ann Oncol, 20, 767-74. crossref(new window)

Carbone P, Kaplan H, Musshoff K, et al (1971). Report of the committee on hodgkin's disease staging classification. Cancer Res, 31, 1860-61.

DeSantis C, Lin C, Mariotto A, et al (2014). Cancer Treatment and Survivorship Statistics. CA Cancer J Clin, 64, 252-71. crossref(new window)

Dinand V, Arya L (2006). Epidemiology of childhood hodgkins disease: is it different in developing countries? Indian Pediatr, 43, 141-47.

Fadhil M, Al-Nueimy W, Lazim A (2014). Hodgkin's lymphoma. an immunohistochemical profile in Northern Iraq. Saudi Med J, 35, 448-53.

Foss Abrahamsen A, Egeland T, Hansen S, et al (1997). Hodgkin's disease in a national and hospital population: trends over 20 years. Eur J Cancer, 33, 2380-83. crossref(new window)

Geller S, Taylor C (2013). Thomas hodgkin: the 'man' and 'his disease': humani nihil a se alienum putabit (nothing human was foreign to him). Virchows Arch, 463, 353-65. crossref(new window)

Gender Statistics. Highlights from (2012). World Development Report (2012). [Online].

Georgii A, Fischer R, Hubner K, et al (1993). Classification of hodgkin's disease biopsies by a panel of four histopathologists. report of 1,140 patients from the German National Trial. Leuk Lymphoma, 9, 365-70. crossref(new window)

Hakobyan T, Nazaretyan M, Makarova T, et al (2006). Armenia: health system review. Health Syst Transit, 8, 1-202.

Harris N (1999). Hodgkin's lymphomas: classification, diagnosis, and grading. Semin Hematol, 36, 220-32.

Hessissen L, Khtar R, Madani A, et al (2013). Improving the prognosis of pediatric hodgkin lymphoma in developing countries: a moroccan society of pediatric hematology and oncology study. Pediatr Blood Cancer, 60, 1464-69 crossref(new window)

Lee M, Tan T, Feng A (2005). Clinico-pathological study of hodgkin's lymphoma in a cancer center in Taiwan. Clin Lab Haematol, 27, 379-83. crossref(new window)

Lister T, Crowther D, Sutcliffe S, et al (1989). Report of a committee convened to discuss the evaluation and staging of patients with hodgkin's disease: cotswolds meeting. J Clin Oncol, 7, 1630-66. crossref(new window)

Macfarlane G, Evstifeeva T, Boyle P, et al (1995). International patterns in the occurrence of hodgkin's disease in children and young adult males. Int J Cancer, 61, 165-69. crossref(new window)

National Statistical Service of Republic of Armenia (2015). [Online].

NCCN Clinical Practice Guidelines in Oncology. Hodgkin Disease/Lymphoma (2008). Vol 2. [Online].

Olu-Eddo A, Omoti C (2011). Hodgkin lymphoma: clinicopathologic features in benin city, nigeria and update on its biology and classification. Niger J Clin Pract, 14, 440-44. crossref(new window)

Ramadas K, Sankaranarayanan R, Nair M, et al (1994). Adult Hodgkin's disease in Kerala. Cancer, 73, 2213-17. crossref(new window)

Richardson E (2013). Armenia: health system review. Health Syst Transit, 15, 1-99.

Riyat M (1992). Hodgkin's disease in Kenya. Cancer, 69, 1047-51. crossref(new window)

Sant M, Allemani C, Tereanu C, et al (2010). Incidence of hematologic malignancies in europe by morphologic subtype: results of the haemacare project. Blood, 116, 3724-34. crossref(new window)

SEER 18 Stat Fact Sheets (2008-2012) - Hodgkin lymphoma. [Online].

Sherief L, Elsafy U, Abdelkhalek E, et al (2015). Hodgkin lymphoma in childhood: clinicopathological features and therapy outcome at 2 centers from a developing country. Med, 94, 670 crossref(new window)

Shimabukuro-Vornhagen A, Haverkamp H, Engert A (2005). Lymphocyte-rich classical Hodgkin's lymphoma: clinical presentation and treatment outcome in 100 patients treated within german hodgkin's study group trials. J Clin Oncol, 23, 5739-45. crossref(new window)

Siddiqui N, Ayub B, Badar F, et al (2006). Hodgkin's lymphoma in Pakistan: a clinico-epidemiological study of 658 cases at a cancer center in Lahore. Asian Pac J Cancer Prev, 7, 651-55.

Sughayer M, Haddad H, Al-Yousef R, et al (2014). Epstein-barr virus and hodgkin lymphoma in Jordan. Hematol Oncol Stem Cell Ther, 7, 85-89. crossref(new window)

Swerdlow S, Campo E, Harris N, et al (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. IARC WHO Classification of Tumours, 2, 1-439.

Torre L, Bray F, Siegel R, et al (2015). Global Cancer Statistics, 2012. CA Cancer J Clin, 65, 87-108. crossref(new window)

World Health Organization Global Health Expenditure Database 2010-2014 (2015). [Online].

Yaqo R , Hughson M, Sulayvani F, et al (2011). Malignant lymphoma in northern Iraq: a retrospective analysis of 270 cases according to the world health organization classification. Indian J Cancer, 48, 446-51 crossref(new window)