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Immunohistochemical Evaluation of Glucose Transporter Type 1 in Epithelial Dysplasia and Oral Squamous Cell Carcinoma
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 Title & Authors
Immunohistochemical Evaluation of Glucose Transporter Type 1 in Epithelial Dysplasia and Oral Squamous Cell Carcinoma
Pereira, Karuza Maria Alves; Feitosa, Sthefane Gomes; Lima, Ana Thayssa Tomaz; Luna, Ealber Carvalho Macedo; Cavalcante, Roberta Barroso; Lima, Kenio Costa de; Chaves, Filipe Nobre; Costa, Fabio Wildson Gurgel;
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 Abstract
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of these have been documented in association or preceded by oral epithelial dysplasia (OED). Aggressive cancers with fast growth have demonstrated overexpression of some glucose transporters (GLUTs). Thus, the aim of this study was to analyze the immunohistochemical expression of the glucose transporter, GLUT-1, in OEDs and OSCCs, seeking to better elucidate the biological behavior of neoplasias. Fifteen cases were selected this research of both lesions. Five areas were analyzed from each case by counting the percentage of positive cells at 400x magnification. Immunoreactivity of GLUT-1 was observed in 100% of the samples ranging from 54.2% to 86.2% for the OSCC and 73.9% to 97.4% for the OED. Statistical test revealed that there was greater overexpression of GLUT-1 in OED than the OSCC (p
 Keywords
Oral squamous cell carcinoma;oral epithelaial dysplaisa;GLUT;immunohistochemistry;
 Language
English
 Cited by
1.
Glycolysis-related protein expression in thyroid cancer, Tumor Biology, 2017, 39, 3, 101042831769592  crossref(new windwow)
 References
1.
Ayala FR, Rocha RM, Carvalho KC, et al (2010). GLUT1 and GLUT3 as potential prognostic markers for oral squamous cell carcinoma. Molecules, 15, 2374-87. crossref(new window)

2.
Demasi AP, Costa AF, Altemani A, et al (2010). Glucose transporter protein 1 expression in mucoepidermoid carcinoma of salivary gland: correlation with grade of malignancy. Int J Exp Pathol, 91, 107-13. crossref(new window)

3.
Funk GF, Karnell LH, Robinson RA, et al (2002). Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head Neck, 24, 165-80. crossref(new window)

4.
Haber RS, Rathan A, Weiser KR, et al (1998). GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer, 83, 34-40. crossref(new window)

5.
Heo K, Kim YH, Sung HJ, et al (2012). Hypoxia-induced upregulation of apelin is associated with a poor prognosis in oral squamous cell carcinoma patients. Oral Oncol, 48, 500-6. crossref(new window)

6.
Kato Y, Tsuta K, Seki K, et al (2007). Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. Mod Pathol, 20, 215-20. crossref(new window)

7.
Kunkel M, Reichert TE, Benz P, et al (2003). Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma. Cancer, 97, 1015-24. crossref(new window)

8.
Macheda ML, Rogers S, Best JD (2005). Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol, 202, 654-62. crossref(new window)

9.
Medina RA, Owen GI (2002). Glucose transporters: expression, regulation and cancer. Biol Res, 35, 9-26.

10.
Mineta H, Miura K, Takebayashi S, et al (2002). Prognostic value of glucose transporter 1 expression in patients with hypopharyngeal carcinoma. Anticancer Res, 22, 3489-94.

11.
Moreno-Sanchez R, Rodriguez-Enriquez S, Marin-Hernandez A, Saavedra E (2007). Energy metabolism in tumor cells. Febs J, 274, 1393-418. crossref(new window)

12.
Moreno-Sanchez R, Rodriguez-Enriquez S, Saavedra E, Marin-Hernandez A, Gallardo-Perez JC (2009). The bioenergetics of cancer: is glycolysis the main ATP supplier in all tumor cells? Biofactors, 35, 209-25. crossref(new window)

13.
Ohba S, Fujii H, Ito S, et al (2010). Overexpression of GLUT-1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis. J Oral Pathol Med, 39, 74-8. crossref(new window)

14.
Oliveira LR, Ribeiro-Silva A (2011). Prognostic significance of immunohistochemical biomarkers in oral squamous cell carcinoma. Int J Oral Maxillofac Surg, 40, 298-307. crossref(new window)

15.
Perussi MR, Denardin OV, Fava AS, Rapoport A (2002). [Squamous cell carcinoma of the mouth in the elderly in Sao Paulo]. Rev Assoc Med Bras, 48, 341-4. crossref(new window)

16.
Reibel J (2003). Tobacco and oral diseases. Update on the evidence, with recommendations. Med Princ Pract, 1, 22-32.

17.
Reisser C, Eichhorn K, Herold-Mende C, Born AI, Bannasch P (1999). Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck. Int J Cancer, 80, 194-8. crossref(new window)

18.
Sakashita M, Aoyama N, Minami R, et al (2001). Glut1 expression in T1 and T2 stage colorectal carcinomas: its relationship to clinicopathological features. Eur J Cancer, 37, 204-9. crossref(new window)

19.
Scully C (2005). Oral cancer; the evidence for sexual transmission. Br Dent J, 199, 203-7. crossref(new window)

20.
Warnakulasuriya S, Johnson NW, van der Waal I (2007). Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med, 36, 575-80. crossref(new window)

21.
Warnakulasuriya S, Reibel J, Bouquot J, Dabelsteen E (2008). Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med, 37, 127-33. crossref(new window)