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Polycyclic Aromatic Hydrocarbons (PAHs) and their Bioaccessibility in Meat: a Tool for Assessing Human Cancer Risk
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 Title & Authors
Polycyclic Aromatic Hydrocarbons (PAHs) and their Bioaccessibility in Meat: a Tool for Assessing Human Cancer Risk
Hamidi, Elliyana Nadia; Hajeb, Parvaneh; Selamat, Jinap; Razis, Ahmad Faizal Abdull;
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 Abstract
Polycyclic aromatic hydrocarbons (PAHs) are primarily formed as a result of thermal treatment of food, especially barbecuing or grilling. Contamination by PAHs is due to generation by direct pyrolysis of food nutrients and deposition from smoke produced through incomplete combustion of thermal agents. PAHs are ubiquitous compounds, well-known to be carcinogenic, which can reach the food in different ways. As an important human exposure pathway of contaminants, dietary intake of PAHs is of increasing concern for assessing cancer risk in the human body. In addition, the risks associated with consumption of barbecued meat may increase if consumers use cooking practices that enhance the concentrations of contaminants and their bioaccessibility. Since total PAHs always overestimate the actual amount that is available for absorption by the body, bioaccessibility of PAHs is to be preferred. Bioaccessibility of PAHs in food is the fraction of PAHs mobilized from food matrices during gastrointestinal digestion. An in vitro human digestion model was chosen for assessing the bioaccessibility of PAHs in food as it offers a simple, rapid, low cost alternative to human and animal studies; providing insights which may not be achievable in in vivo studies. Thus, this review aimed not only to provide an overview of general aspects of PAHs such as the formation, carcinogenicity, sources, occurrence, and factors affecting PAH concentrations, but also to enhance understanding of bioaccessibility assessment using an in vitro digestion model.
 Keywords
Polycyclic aromatic hydrocarbons;barbecued meat;bioaccessibility;in vitro human digestion model;
 Language
English
 Cited by
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Asian Pacific Journal of Cancer Prevention, 2016. vol.17. 9, pp.4301-4306 crossref(new window)
1.
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat, Archives of Toxicology, 2017, 91, 10, 3415  crossref(new windwow)
 References
1.
Abou-Arab AAK, Abou-Donia MA, El-Dars FMSE, et al (2014). Detection of polycyclic aromatic hydrocarbons levels in Egyptian meat and milk after heat treatment by gas chromatography-mass spectrometry. Int J Curr Microbiol App Sci, 3, 294-305.

2.
Afzaninawati SY, Zaleha MI, Shamsul AS (2013). Perceptions of Malaysian colorectal cancer patients regarding dietary intake: A qualitative exploration. Asian Pac J Cancer Prev, 14, 1151-54. crossref(new window)

3.
Akpambanga VOE, Purcaro G, Lajide L, et al (2009). Determination of polycyclic aromatic hydrocarbons (PAHs) in commonly consumed Nigerian smoked/grilled fish and meat. Food Addit Contam: A, 26, 1096-1103. crossref(new window)

4.
Alomirah H, Al-Zenki S, Al-Hooti S, et al (2011). Concentrations and dietary exposure to polycyclic aromatic hydrocarbons (PAHs) from grilled and smoked foods. Food Control, 22, 2028-35. crossref(new window)

5.
Al-Rashdan A, Helaleh MIH, Nisar A, et al (2010). Determination of the levels of polycyclic aromatic hydrocarbons toasted bread using gas chromatography mass spectrometry. Int J of Anal Chem, doi:10.1155/2010/821216. crossref(new window)

6.
Anderson KE, Sinha R, Kulldorff M, et al (2002). Meat intake and cooking techniques: associations with pancreatic cancer. Mutat Res, 506-507, 225-31. crossref(new window)

7.
Chung SY, Yetella RR, Kim JS, et al (2011). Effects of grilling and roasting on the levels of polycyclic aromatic hydrocarbons in beef and pork. Food Chem, 129, 1420-26. crossref(new window)

8.
Coles LT, Moughan PJ, Darragh, AJ (2005). In vitro digestion and fermentation methods, including gas production techniques, as applied to nutritive evaluation of foods in the hindgut of humans and other simple-stomached animals. Anim Feed Sci Tech, 123-124, 421-44. crossref(new window)

9.
Danyi S, Brose F, Brasseur C, et al (2009). Analysis of EU priority polycyclic aromatic hydrocarbons in food supplements using high performance liquid chromatography coupled to an ultraviolet, diode array or fluorescence detector. Analytica Chimica Acta, 633, 293-9. crossref(new window)

10.
El-Badry, N (2010). Effect of household cooking methods and some food additives on polycyclic aromatic hydrocarbons (PAHs) formation in chicken meat. World Applied Sciences Journal, 9, 963-74.

11.
Farhadian A, Jinap S, Faridah A, et al (2010). Determination of polycyclic aromatic hydrocarbon in grilled meat. Food Control, 21, 606-10. crossref(new window)

12.
Farhadian A, Jinap S, Faridah A, et al (2012). Effects of marinating on the formation of polycyclic aromatic hydrocarbons (benzo[a]pyrene, benzo[b]fluoranthene and fluoranthene) in grilled beef meat. Food Control, 28, 420-5. crossref(new window)

13.
Farhadian A, Jinap S, Hanifah HN, et al (2011). Effects of meat preheating and wrapping on the levels of polycyclic aromatic hydrocarbons in charcoal-grilled meat. Food Chem, 124, 141-6. crossref(new window)

14.
Gomes A, Roseiro C, Santos C (2009). Determination of polycyclic aromatic hydrocarbons profile in Portugese traditional dry fermented sausage. V Food Safety European Symposium, Berlin, Germany.

15.
Hu J, Wu F, Wu S, et al (2013). Bioaccessibility, dietary exposure and human risk assessment of heavy metals from market vegetables in hong kong revealed with an in vitro gastrointestinal model. Chemosphere, 91, 455-61. crossref(new window)

16.
Hur SJ, Lim BO, Decker EA, et al (2011). In vitro human digestion models for food applications. Food Chem, 125, 1-12. crossref(new window)

17.
Intawongse M, Dean JR (2006). In-vitro testing for assessing oral bioaccessibility of trace metals in soil and food samples. Trend in Analytical Chemistry, 25, 9.

18.
International Agency for Research on Cancer (IARC) (1987). Overall evaluations of carcinogenicity. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Lyon, France, 440, 7.

19.
International Agency for Research on Cancer (IARC) (2004). Overall evaluations of carcinogenicity: An updating of IARC monographs. Lyon, France, 1-42, 7.

20.
International Agency for Research on Cancer (IARC) (2010). Monographs on the evaluation of carcinogenic risk to humans. Some on-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. Lyon, France, 92, 360-437.

21.
Ishizaki A, Saito K, Hanioka N, et al (2010). Determination of polycyclic aromatic hydrocarbons in food samples by automated on-line in-tube solid-phase microextraction coupled with high-performance liquid chromatographyfluorescence detection. J Chromatogr A, 1217, 5555-63. crossref(new window)

22.
Jagerstad M, Skog K (2005). Genotoxicity of heat-processed foods. Mutat Res, 574, 156-72. crossref(new window)

23.
Jahurul MHA, Jinap S, Zaidul ISM, et al (2013). Determination of fluoranthene, benzo(b)fluoranthene and benzo(a)pyrene in meat and fish product and their intake by Malaysian. Food Bioscience, 1, 73-80. crossref(new window)

24.
Janoszka B, Warzecha L, Blaszczyk U, et al (2004). Organic compound formed in thermally treated high-protein food part i: polycyclic aromatic hydrocarbons. Acta Chromatographica, 14, 115-28.

25.
Jarvis IWH, Dreiji K, Mattson A, et al (2014). Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment. Toxicol, 321, 27-39. crossref(new window)

26.
Jinap S, Mohd-Mokhtar MS, Farhadian A, et al (2013). Effects of varying degrees of doneness on the formation of heterocyclic aromatic amines in chicken and beef satay. Meat Sci, 94, 202-7. crossref(new window)

27.
Jira W (2004). A GC/MS method for the determination of carcinogenic polycyclic aromatic hydrocarbons (PAHs) in smoked meat products and liquid smokes. Eur Food Res Technol, 218, 208-12. crossref(new window)

28.
Knightes CD, Peters CA (2006). Multisubstrate biodegradation kinetics for binary and complex mixtures of polycyclic aromatic hydrocarbons. Environ Toxicol Chem, 25, 1746-56. crossref(new window)

29.
Kulp KS, Fortson SL, Kniza MG, et al (2003). An in vitro model system to predict the bioaccessibility of heterocyclic amines from a cooked meat matrix. Food Chem Toxicol, 4, 1701- 10.

30.
Marchand LL, Hankin JH, Pierce LM, et al (2002). Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii. Mutat Res, 506-507, 205-14. crossref(new window)

31.
Marques A, Lourenco HM, Nunes ML, et al (2011). New tools to assess toxicity, bioaccessibility and uptake of chemical contaminants in meat and seafood. Food Res Int, 44, 510-22. crossref(new window)

32.
Marti-Cid R, Llobet JM, Castell V, et al (2008). Evolution of the dietary exposure to polycyclic aromatic hydrocarbons in Catalonia, Spain. Food Chem Toxicol, 46, 3163-71. crossref(new window)

33.
Martorell I, Perello G, Marti-Cid R, et al (2010). Polycyclic aromatic hydrocarbons (PAHs) in foods and estimated PAH intake by the population of Catalonia, Spain, temporal trend. Environ Int, 36, 424-32. crossref(new window)

34.
Maulvault AL, Raquel M, Claudia A, et al (2011). Bioaccessibility of Hg, Cd and As in cooked black scabbard fish and edible crab. Food Chem Toxicol, 49, 2808-15. crossref(new window)

35.
Omar NA, Praveena SM, Aris AZ, et al (2013). Bioavailability of heavy metals in rice using in vitro digestion model. Int Food Res J, 20, 2979-85.

36.
Omwukeme VI, Obijiofor OC, Asomugha RN, et al (2015). impact of cooking methods on the levels of polycyclic aromatic hydrocarbons (PAHs) in chicken meat. IOSR J of Environ Sci, Toxicol and Food Technol, 9, 21-7.

37.
Oomen AG, Rompelberg CJM, Bruil MA, et al (2003). Development of an in vitro digestion model to estimating the bioaccessibility of soil contaminants. Arch Environ Contam Toxicol, 44, 281-7. crossref(new window)

38.
Palm MNL, Derick C, Yeboah PO, et al (2011). Characterization of polycyclic aromatic hydrocarbon (PAHs) present in smoked fish from Ghana. Adv J Food Sci Technol, 3, 332-8.

39.
Perello G, Marti-Cid R, Castell V, et al (2009). Concentrations of polybrominated diphenyl ethers, hexachlorobenzene and polycyclic aromatic hydrocarbons in various foodstuffs before and after cooking. Food Chem Toxicol, 47, 709-15. crossref(new window)

40.
Plaza-Bolanos P, Frenich AG, Vidal JLM (2010). Polycyclic aromatic hydrocarbons in food and beverages. Analytical methods and trends. J Chromatogr A, 1217, 6303-26. crossref(new window)

41.
Purcaro G, Moret S, Conte LS (2013). Overview on polycyclic aromatic hydrocarbons: Occurrence, legislation and innovative determination in foods. Talanta, 105, 292-305. crossref(new window)

42.
Ramesh A, Walker SA, Hood DB, et al (2004). Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons. Int J Toxicol, 23, 301-33. crossref(new window)

43.
Reinik M, Tamme T, Roasto M, et al (2007). Polycyclic aromatic hydrocarbons (PAHs) in meat products and estimated PAH intake by children and the general population in Estonia. Food Addit Contam, 24, 429-37. crossref(new window)

44.
Roseiro LC, Gomes A, Santos C (2008). Polycyclic aromatic hydrocarbons profile in a Portugese traditional meat product. IAFP's Fourth European Symposium on Food Safety. Advancements in Food Safety, 19-21 November, Lisbon, Portugal. 47.

45.
Silva BO, Adetunde OT, Oluseyi TO, et al (2011). Effects of the methods of smoking on the levels of PAH in some locally consumed fishes in Nigeria. African Journal of Food Science, 5, 284-391.

46.
Simko P (2002). Determination of polycyclic aromatic hydrocarbons in smoked meat products and smoke flavouring food additives. J Chromatogr B, 770, 3-18. crossref(new window)

47.
Sinha R, Chow WH, Kulldorff M, et al (1999). Well-done grilled red meat increases the risk of colorectal adenomas. Cancer Res, 59, 4320-24.

48.
Sinha R, Rothman N, Salmon CP, et al (1998). Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings. Food Chem Toxicol, 36, 279-87. crossref(new window)

49.
Tang X, Tang L, Zhu Y, et al (2006). Assessment of the bioaccessibility of polycyclic aromatic hydrocarbons in soils from Beijing using an in vitro test. Environ Pollut, 140, 279-85. crossref(new window)

50.
Versantvoort C, Van de Kamp E, Rompelberg C (2004). Development and applicability of an in vitro digestion model in assessing the bioaccessibility of contaminants from food. Report no. 320102002. National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

51.
Viegas O, Novo P, Pinto E, et al (2012). Effect of charcoal types and grilling conditions on formation of heterocyclic aromatic amines (HAs) and polycyclic aromatic hydrocarbons (PAHs) in grilled muscle foods. Food Chem Toxicol, 50, 2128-34. crossref(new window)

52.
Wang H, Zhao Y, Man Y, et al (2011). Oral bioaccessibility and human risk assessment of organochlorine pesticides (OCPs) via fish consumption, using an in vitro gastrointestinal model. Food Chem, 127, 1673-79. crossref(new window)

53.
Yu Y, Chen L, Yang D, et al (2012). Polycyclic aromatic hydrocarbons in animal-based foods from Shanghai: bioaccessibility and dietary exposure. Food Addit Contam A, 29, 1465-74. crossref(new window)

54.
Yu Y, Huang N, Zhang X, et al (2011). Polybrominated diphenyl ethers in food and associated human daily intake assessment considering bioaccessibility measured by simulated gastrointestinal digestion. Chemosphere, 83, 152-60. crossref(new window)

55.
Yu Y, Li J, Zhang X, et al (2010). An assessment of the bioaccessibility of polybrominated diphenyl ethers in foods and the correlations of the bioaccessibility with nutrient contents. J Agric Food Chem, 58, 301-8. crossref(new window)