JOURNAL BROWSE
Search
Advanced SearchSearch Tips
Symptom Prevalence and Related Distress in Cancer Patients Undergoing Chemotherapy
facebook(new window)  Pirnt(new window) E-mail(new window) Excel Download
 Title & Authors
Symptom Prevalence and Related Distress in Cancer Patients Undergoing Chemotherapy
Thiagarajan, Muthukkumaran; Chan, Caryn Mei Hsien; Fuang, Ho Gwo; Beng, Tan Seng; Atiliyana, MA; Yahaya, NA;
  PDF(new window)
 Abstract
Background: Much has been done to examine the psychological impact of cancer treatment, but it remains unclear to what extent anxiety and depression is related to symptom prevalence. The present study concerned the characteristics and frequency of distress as related to symptom prevalence in cancer patients undergoing chemotherapy in Malaysia. Materials and Methods: Participants were 303 consecutive adult cancer patients undergoing chemotherapy in an academic medical center. The short form Memorial Symptom Assessment Scale (MSAS-SF), which covers three domains of symptoms (global distress, physical- and psychological symptoms) was used to cross-sectionally measure symptom frequency and associated distress via self-reporting. One-way ANOVA and t-tests were used to test mean differences among MSAS-SF subscale scores. Results: Complete data were available for 303 patients. The mean number of symptoms was 14.5. The five most prevalent were fatigue, dry mouth, hair loss, drowsiness and lack of appetite. Overall, symptom burden and frequency were higher than in other published MSAS-SF studies. Higher symptom frequency was also found to be significantly related to greater distress in cancer patients undergoing chemotherapy. Conclusions: Patients undergoing chemotherapy suffer from multiple physical and psychological symptoms. Better symptom control or palliative care is needed. Greater frequency of reported symptoms may also indicate a subconscious bid by patients for care and reassurance - thus tailored intervention to manage distress should be offered.
 Keywords
Cancer;chemotherapy;symptom prevalence;distress;psychosomatic effects;
 Language
English
 Cited by
 References
1.
Akechi T, Okuyama T, Endo C, et al (2011). Patient's perceived need and psychological distress and/or quality of life in ambulatory breast cancer patients in Japan. Psycho Oncol, 20, 497-505. crossref(new window)

2.
Akin S, Can G, Avdiner A, et al (2010). Quality of life, symptom experience and distress of lung cancer patients undergoing chemotherapy. Eur J Oncol Nurs, 14, 400-9. crossref(new window)

3.
Borjeson S, Starkhammar H, Unosson M, Bertero C (2012). Common symptoms and distress experienced among patients with colorectal cancer: a qualitative part of mixed method design. Open Nurs J, 6, 100-7. crossref(new window)

4.
Breen SJ, Baravelli CM, Schofield PE, et al (2009). Is symptom burden a predictor of anxiety and depression in patients with cancer about to commence chemotherapy? Med J Aust, 190, 99-104.

5.
Chang VT, Huang SS, Feuerman M, et al (2000a). Symptom and quality of life survey of medical oncology patients at a veteran affairs medical centre: a role for symptom assessment. Cancer, 88, 1175-83. crossref(new window)

6.
Chang VT, Huang SS, Feuerman M, et al (2000b). Memorial symptoms assessment scale short form. Cancer, 89, 1162-71. crossref(new window)

7.
Cleeland CS (2007). Symptom burden: multiple symptoms and their impact as patient-reported outcomes. J Natl Cancer Inst Monogr, 37, 16-21.

8.
Cooley ME, Short TH, Moriarty HJ, et al (2003). Symptom prevalence, distress and change over time in adults receiving treatment for lung cancer. Psycho Oncol, 12(7), 694-708. crossref(new window)

9.
Delgado-Guay M, Parsons HA, Li Z, et al (2009). Symptom distress in advanced cancer patients with anxiety and depression in the palliative care setting. Support Care Cancer, 17, 573-9. crossref(new window)

10.
Ferguson RJ, Ahles TA (2003). Low neuropsychologic performance among adult cancer survivors treated with chemotherapy. Curr Neurol Neurosci Rep, 3, 215-22. crossref(new window)

11.
Fitzgerald P, Lo C, Li M, Gagliese L, Zimmerman C, Rodin G (2013). The relationship between depression and physical symptom burden in advanced cancer. BMJ Support Palliat Care, 5, 381-8

12.
Heyn L, Ruland CM, Finset A (2012). Effects of an interactive tailored assessment tool on eliciting and responding to cancer patients' cues and concerns in clinical consultations with physicians and nurses. Pat Educ Counsel, 86, 158-65. crossref(new window)

13.
Huijer HA, Abboud S, Doumit M (2012). Symptom prevalence and management of cancer patients in Lebanon. J Pain Symptom Manage, 44, 386-99. crossref(new window)

14.
Illi J, Miaskowski C, Cooper B, et al (2012). Association between pro- and anti-inflammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression. Cytokine, 58, 437-47. crossref(new window)

15.
Kim JE, Dodd MJ, Aouizerat BE, et al (2009). A review of prevalence and impact of multiple symptoms in oncology patients. J Pain Symptom Manage, 37, 715-36. crossref(new window)

16.
Kroenke K, Johns SA, Theobald D, Wu J, Tu W (2013). Somatic symptoms in cancer patients trajectory over 12 months and impact on functional status and disability. Support Care Cancer, 21, 765-73. crossref(new window)

17.
Lobchuk MM, Degner LF (2002). Symptom experiences: perceptual accuracy between advanced stage cancer patients and family care-givers in the home care setting. J Clin Oncol, 20, 3495-507. crossref(new window)

18.
Manitta V, Zordan R, Cole-Sinclair M, et al (2011). The symptom burden of patients with haematological malignancy: a crosssectional observational study. J Pain Symptom Manage, 42, 432-42. crossref(new window)

19.
Miaskowski C, Cooper BA, Melisko M, et al (2014). Disease and treatment characteristics do not predict symptom occurrence profiles in oncology outpatients receiving chemotherapy. Cancer, 120, 2371-8. crossref(new window)

20.
Oh HS, So WS (2010). Systematic review and meta-analysis of the correlates of cancer related-fatigue. Evidence Based Nursing, 191-201.

21.
Petterson G, Bertero C, Unosson M, Borjeson S (2014). Symptom prevalence, frequency, severity, and distress during chemotherapy for patients with colorectal cancer. Support Care Cancer, 22, 1171-9. crossref(new window)

22.
Portenoy RK, Thaler HT, Kornblith AB, et al (1994a). Symptom prevalence, characteristics and distress in a cancer population. Qual Life Res, 3, 183-9. crossref(new window)

23.
Portenoy RK, Kornblith AB, Wong G, et al (1994b). Prevalance, characteristics and associated symptoms. Cancer, 74, 907-15. crossref(new window)

24.
Reilly CM, Bruner DW, Mitchell, et al (2013). A literature synthesis of symptom prevalence and severity in persons receiving active cancer treatment. Support Care Cancer, 21, 1525-50. crossref(new window)

25.
Rhodes VA, Watson PM (1987). Symptom distress - the concept: Past and present. Seminars Oncol Nurs, 3, 242-7. crossref(new window)

26.
Stasi R, Abriani L, Baccaglia P, et al (2003). Cancer-related fatigue: Evolving concepts in evaluation and treatment. Cancer, 98, 1786-801. crossref(new window)

27.
Sun CC, Bodurka DC, Weaver CB, et al (2005). Rankings and symptom assessment of side effects of chemotherapy: insight from experienced patients with ovarian cancer. Support Care Cancer, 13, 219-27. crossref(new window)

28.
Spichiger E, Muller-Frohlich C, Denhaerynck K, et al (2011). Prevalence of symptoms, with a focus on fatigue, and changes of symptoms over three months in outpatients receiving cancer chemotherapy. Swiss Medical Weekly, 141, 13303

29.
Tchekmedyian NS, Kallich J, McDermott A, et al (2003). The relationship between psychologic distress and cancer related fatigue. Cancer, 98, 198-203. crossref(new window)

30.
Uitterhoeve R, Bensing J, Dilven E, et al (2009). Nurse-patient communication in cancer care: does responding to patient's cues predict patient satisfaction with communication. Psycho Oncol, 18, 1060-8. crossref(new window)

31.
Valentine AD, Meyers CA (2001). Cognitive and mood disturbances as causes and symptoms of fatigue in cancer patients. Cancer, 92, 1694-8. crossref(new window)

32.
Walling AM, Weeks JC, Kahn KL, et al (2014). Symptom prevalence in lung and colorectal cancer patients. J Pain Symptom Manage, 49, 192-202.

33.
Yahaya NA, Subramaniam P, Bustam AZ, Taib NA (2015). Symptom experiences and coping strategies among multiethnic solid tumor patients undergoing chemotherapy in Malaysia, Asian Pac J Cancer Prev, 16, 723-30. crossref(new window)

34.
Zabora J, Brintzenhofe SK, Curbow B, et al (2001). The prevalence of psychological distress by cancer site. Psycho Oncol, 10, 19-28. crossref(new window)