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Incidence of Active HCV infection amongst Blood Donors of Mardan District, Pakistan
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 Title & Authors
Incidence of Active HCV infection amongst Blood Donors of Mardan District, Pakistan
Karim, Fawad; Nasar, Abu; Alam, Ibrar; Alam, Iftikhar; Hassan, Said; Gul, Rahmat; Ullah, Sana; Rizwan, Muhammad;
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 Abstract
Hepatitis C is an ailment of liver caused by hepatitis C virus (HCV) infection. About 3% of the world population is infected by this virus. HCV infection is a leading reason for liver cirrhosis and therefore a major source of hepatocellular carcinoma. The study focused on the incidence of active HCV infection in blood donors of Mardan district of KPK, Pakistan. A total of 5318 blood donors were inspected for the presence of anti-HCV antibodies and HCV-RNA using ICT (immune-chromatographic test), ELISA and RT-PCR at Mardan Medical Complex (MMC), Mardan. Out of these, 157 (2.95%) were positive by ICT, 60 (1.12%) by ELISA and 56 (1.05%) for HCV-RNA. The frequency of active HCV infectivity amongst the blood donors from district Mardan, KPK Pakistan was 1.05 %. Application of strict measures during blood donor selection and use of proper screening assays such as ELISA in place of ICT devices can give a more accurate picture so that the incidence of this viral infection in HCV negative blood recipients can be reduced.
 Keywords
HCV;ELISA;RT-PCR;viral infection rates;
 Language
English
 Cited by
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Hepatitis C Virus and Interferon-Free Antiviral Therapeutics Revolution: Implications for Pakistan, Viral Immunology, 2017, 30, 4, 252  crossref(new windwow)
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